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• W2575697875 abstract "ABSTRACT Objective To investigate the potential value of repeat measurements of uterine artery pulsatility index ( UtA‐PI ), mean arterial pressure ( MAP ) and serum placental growth factor ( PlGF ) at 12, 22 and 32 weeks' gestation in the prediction of pre‐eclampsia ( PE ) developing after 32 weeks. Methods Data were derived from prospective screening for adverse obstetric outcomes in women attending their routine hospital visit at 11–13, 19–24 and/or 30–34 weeks' gestation in two maternity hospitals in England. UtA‐PI , MAP and PlGF were measured. Bayes' theorem was used to combine the a‐priori risk from maternal factors with UtA‐PI , MAP and PlGF multiples of the median values. The performance of screening for PE developing after the 30–34‐week visit by UtA‐PI , MAP and PlGF measured at 11–13, 19–24 and 30–34 weeks and their combinations was examined. Results Screening at 30–34 weeks by UtA‐PI , MAP and PlGF detected, at a 10% false‐positive rate, 79%, 86% and 92% of preterm PE and 42%, 50% and 56% of term PE . The addition of biomarker values at 11–13 and/or 19–24 weeks was not associated with any improvement in the detection rate of preterm PE ; in the case of term PE , there was a marginal (< 2%) improvement in detection for UtA‐PI and MAP and a modest improvement of about 5% for PlGF . Conclusion Measurements of UtA‐PI , MAP and PlGF in the first and/or second trimester have a small or no effect on improving the prediction of PE provided by screening in the early third trimester. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd." @default.
• W2575697875 created "2017-01-26" @default.
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• W2575697875 date "2017-07-09" @default.
• W2575697875 modified "2023-10-08" @default.
• W2575697875 title "Repeat measurements of uterine artery pulsatility index, mean arterial pressure and serum placental growth factor at 12, 22 and 32 weeks in prediction of pre-eclampsia" @default.
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• W2575697875 doi "https://doi.org/10.1002/uog.17403" @default.
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