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- W2575720495 endingPage "1038" @default.
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- W2575720495 abstract "Tumor metastasis is defined as the spread of tumor cells from one organ or part to another that is not directly connected to it, which significantly contributes to the progression and aggravation of tumorigenesis. Because it always involves multiple organs, the metastatic process is difficult to study in its entirety. Complete identification of the genes related to this process is an alternative way to study metastasis. In this study, we developed a computational method to identify such genes. To test our method, we selected breast cancer bone metastasis. A large network was constructed using human protein-protein interactions. On the basis of the validated genes related to breast and bone cancer, a shortest path algorithm was applied to the network to search for novel genes that may mediate breast cancer metastasis to bone. In addition, further rules constructed using the permutation FDR, the betweenness ratio, and the max-min interaction score were also employed in the method to make the inferred genes more reliable. Eighteen putative genes were identified by the method and were extensively analyzed. The confirmation results indicate that these genes participate in metastasis." @default.
- W2575720495 created "2017-01-26" @default.
- W2575720495 creator A5025077602 @default.
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- W2575720495 creator A5046736908 @default.
- W2575720495 creator A5066807605 @default.
- W2575720495 creator A5076748700 @default.
- W2575720495 date "2017-01-23" @default.
- W2575720495 modified "2023-09-25" @default.
- W2575720495 title "Identification of Genes Associated with Breast Cancer Metastasis to Bone on a Protein–Protein Interaction Network with a Shortest Path Algorithm" @default.
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