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- W2575808097 endingPage "20160160" @default.
- W2575808097 startingPage "20160160" @default.
- W2575808097 abstract "The proinflammatory cytokine tumour necrosis factor-alpha (TNFα) has long been characterized for its role in the innate immune system, but more recently has been found to have a distinct role in the nervous system that does not overlap with other proinflammatory cytokines. Through regulation of neuronal glutamate and GABA receptor trafficking, TNF mediates a homeostatic form of synaptic plasticity, but plays no direct role in Hebbian forms of plasticity. As yet, there is no evidence to suggest that this adaptive plasticity plays a significant role in normal development, but it does maintain neuronal circuit function in the face of several types of disruption. This includes developmental plasticity in primary sensory cortices, as well as modulating the response to antidepressants, chronic antipsychotics and drugs of abuse. TNF is also a prominent component of the neuroinflammation occurring in most neuropathologies, but the role of TNF-mediated synaptic plasticity in this context remains to be determined. We tested this in a maternal immune activation (MIA) model of neurodevelopmental disorders. Using TNF −/− mice, we observed that TNF is not required for the expression of abnormal social or anxious behaviour in this model. This indicates that TNF does not uniquely contribute to the development of neuronal dysfunction in this model, and suggests that during neuroinflammatory events, compensation between the various proinflammatory cytokines is the norm. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’." @default.
- W2575808097 created "2017-01-26" @default.
- W2575808097 creator A5040278241 @default.
- W2575808097 creator A5043745260 @default.
- W2575808097 date "2017-03-05" @default.
- W2575808097 modified "2023-09-25" @default.
- W2575808097 title "Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation" @default.
- W2575808097 cites W1485248315 @default.
- W2575808097 cites W1518896693 @default.
- W2575808097 cites W1541486667 @default.
- W2575808097 cites W1542136448 @default.
- W2575808097 cites W1548862642 @default.
- W2575808097 cites W1785970105 @default.
- W2575808097 cites W1965513983 @default.
- W2575808097 cites W1968295892 @default.
- W2575808097 cites W1970314590 @default.
- W2575808097 cites W1970565358 @default.
- W2575808097 cites W1971233916 @default.
- W2575808097 cites W1972988703 @default.
- W2575808097 cites W1980320018 @default.
- W2575808097 cites W1980326767 @default.
- W2575808097 cites W1982811887 @default.
- W2575808097 cites W1982921723 @default.
- W2575808097 cites W1984943998 @default.
- W2575808097 cites W1986281170 @default.
- W2575808097 cites W1988682809 @default.
- W2575808097 cites W1990445317 @default.
- W2575808097 cites W1990999239 @default.
- W2575808097 cites W1994874327 @default.
- W2575808097 cites W1996087940 @default.
- W2575808097 cites W1999172174 @default.
- W2575808097 cites W2003282693 @default.
- W2575808097 cites W2007655172 @default.
- W2575808097 cites W2010588199 @default.
- W2575808097 cites W2011085253 @default.
- W2575808097 cites W2011825287 @default.
- W2575808097 cites W2013263136 @default.
- W2575808097 cites W2013887960 @default.
- W2575808097 cites W2013906894 @default.
- W2575808097 cites W2016575029 @default.
- W2575808097 cites W2016634594 @default.
- W2575808097 cites W2020342943 @default.
- W2575808097 cites W2020651859 @default.
- W2575808097 cites W2022230955 @default.
- W2575808097 cites W2022654189 @default.
- W2575808097 cites W2024028366 @default.
- W2575808097 cites W2030862564 @default.
- W2575808097 cites W2031337229 @default.
- W2575808097 cites W2033880528 @default.
- W2575808097 cites W2034114163 @default.
- W2575808097 cites W2035713221 @default.
- W2575808097 cites W2036742551 @default.
- W2575808097 cites W2036768211 @default.
- W2575808097 cites W2039047032 @default.
- W2575808097 cites W2040408325 @default.
- W2575808097 cites W2040506298 @default.
- W2575808097 cites W2044315491 @default.
- W2575808097 cites W2057173639 @default.
- W2575808097 cites W2057476473 @default.
- W2575808097 cites W2062240346 @default.
- W2575808097 cites W2063547860 @default.
- W2575808097 cites W2064520650 @default.
- W2575808097 cites W2064622297 @default.
- W2575808097 cites W2065494319 @default.
- W2575808097 cites W2066027939 @default.
- W2575808097 cites W2068766837 @default.
- W2575808097 cites W2069465895 @default.
- W2575808097 cites W2070438913 @default.
- W2575808097 cites W2071967920 @default.
- W2575808097 cites W2072878021 @default.
- W2575808097 cites W2074075153 @default.
- W2575808097 cites W2074881372 @default.
- W2575808097 cites W2075229326 @default.
- W2575808097 cites W2076362385 @default.
- W2575808097 cites W2077775532 @default.
- W2575808097 cites W2079187454 @default.
- W2575808097 cites W2081670759 @default.
- W2575808097 cites W2085571457 @default.
- W2575808097 cites W2086255604 @default.
- W2575808097 cites W2089224748 @default.
- W2575808097 cites W2089767112 @default.
- W2575808097 cites W2091447278 @default.
- W2575808097 cites W2097071826 @default.
- W2575808097 cites W2098277878 @default.
- W2575808097 cites W2098343308 @default.
- W2575808097 cites W2104000439 @default.
- W2575808097 cites W2116134868 @default.
- W2575808097 cites W2116277576 @default.
- W2575808097 cites W2125531274 @default.
- W2575808097 cites W2132438753 @default.
- W2575808097 cites W2134209166 @default.
- W2575808097 cites W2154965665 @default.
- W2575808097 cites W2155424525 @default.
- W2575808097 cites W2156979281 @default.
- W2575808097 cites W2158205940 @default.
- W2575808097 cites W2161703304 @default.
- W2575808097 cites W2166094199 @default.
- W2575808097 cites W2168250667 @default.