Matches in SemOpenAlex for { <https://semopenalex.org/work/W2575898320> ?p ?o ?g. }
- W2575898320 abstract "Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone. By definition, patients with MGRS do not meet the criteria for overt multiple myeloma/B-cell proliferation, and the hematologic disorder is generally consistent with monoclonal gammopathy of undetermined significance (MGUS). However, MGRS is associated with high morbidity due to the severity of renal and sometimes systemic lesions induced by the MIg. Early recognition is crucial, as suppression of MIg secretion by chemotherapy often improves outcomes. The spectrum of renal diseases in MGRS is wide, including old entities such as AL amyloidosis and newly described lesions, particularly proliferative glomerulonephritis with monoclonal Ig deposits and C3 glomerulopathy with monoclonal gammopathy. Kidney biopsy is indicated in most cases to determine the exact lesion associated with MGRS and evaluate its severity. Diagnosis requires integration of morphologic alterations by light microscopy, immunofluorescence (IF), electron microscopy, and in some cases by IF staining for Ig isotypes, immunoelectron microscopy, and proteomic analysis. Complete hematologic workup with serum and urine protein electrophoresis, immunofixation, and serum-free light-chain assay is required. This review addresses the pathologic and clinical features of MGRS lesions, indications of renal biopsy, and a proposed algorithm for the hematologic workup." @default.
- W2575898320 created "2017-01-26" @default.
- W2575898320 creator A5000308170 @default.
- W2575898320 creator A5016853434 @default.
- W2575898320 creator A5022179123 @default.
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- W2575898320 creator A5073207965 @default.
- W2575898320 creator A5080032606 @default.
- W2575898320 date "2015-01-01" @default.
- W2575898320 modified "2023-09-27" @default.
- W2575898320 title "Diagnosis of monoclonal gammopathy of renal" @default.
- W2575898320 cites W112085206 @default.
- W2575898320 cites W1481223027 @default.
- W2575898320 cites W1509587661 @default.
- W2575898320 cites W1580898910 @default.
- W2575898320 cites W173435793 @default.
- W2575898320 cites W1893155710 @default.
- W2575898320 cites W1955975006 @default.
- W2575898320 cites W1963866884 @default.
- W2575898320 cites W1969991924 @default.
- W2575898320 cites W1971703603 @default.
- W2575898320 cites W1973566860 @default.
- W2575898320 cites W1974768618 @default.
- W2575898320 cites W2005832420 @default.
- W2575898320 cites W2009073165 @default.
- W2575898320 cites W2012147155 @default.
- W2575898320 cites W2014233488 @default.
- W2575898320 cites W2022706857 @default.
- W2575898320 cites W2022856048 @default.
- W2575898320 cites W2023603647 @default.
- W2575898320 cites W2024639218 @default.
- W2575898320 cites W2025310286 @default.
- W2575898320 cites W2028314592 @default.
- W2575898320 cites W2028587572 @default.
- W2575898320 cites W2033061587 @default.
- W2575898320 cites W2033793452 @default.
- W2575898320 cites W2034325115 @default.
- W2575898320 cites W2039881612 @default.
- W2575898320 cites W2042950300 @default.
- W2575898320 cites W2043273269 @default.
- W2575898320 cites W2044506636 @default.
- W2575898320 cites W2046778650 @default.
- W2575898320 cites W2047268224 @default.
- W2575898320 cites W2049365670 @default.
- W2575898320 cites W2050264879 @default.
- W2575898320 cites W2051345199 @default.
- W2575898320 cites W2056744071 @default.
- W2575898320 cites W2059526411 @default.
- W2575898320 cites W2059993555 @default.
- W2575898320 cites W2060013627 @default.
- W2575898320 cites W2063772107 @default.
- W2575898320 cites W2067979640 @default.
- W2575898320 cites W2070177572 @default.
- W2575898320 cites W2070335603 @default.
- W2575898320 cites W2071134058 @default.
- W2575898320 cites W2075161114 @default.
- W2575898320 cites W2077080428 @default.
- W2575898320 cites W2081127262 @default.
- W2575898320 cites W2081672987 @default.
- W2575898320 cites W2082987637 @default.
- W2575898320 cites W2083326938 @default.
- W2575898320 cites W2086702450 @default.
- W2575898320 cites W2086990334 @default.
- W2575898320 cites W2093780976 @default.
- W2575898320 cites W2094208515 @default.
- W2575898320 cites W2095093474 @default.
- W2575898320 cites W2100318165 @default.
- W2575898320 cites W2102738326 @default.
- W2575898320 cites W2108020531 @default.
- W2575898320 cites W2110096325 @default.
- W2575898320 cites W2111080788 @default.
- W2575898320 cites W2111523640 @default.
- W2575898320 cites W2111750889 @default.
- W2575898320 cites W2112889395 @default.
- W2575898320 cites W2114500050 @default.
- W2575898320 cites W2116275357 @default.
- W2575898320 cites W2119071301 @default.
- W2575898320 cites W2123225641 @default.
- W2575898320 cites W2124211478 @default.
- W2575898320 cites W2124240218 @default.
- W2575898320 cites W2124473981 @default.
- W2575898320 cites W2129217896 @default.
- W2575898320 cites W2133267465 @default.
- W2575898320 cites W2134800117 @default.
- W2575898320 cites W2138773190 @default.
- W2575898320 cites W2140350573 @default.
- W2575898320 cites W2140922530 @default.
- W2575898320 cites W2143073280 @default.
- W2575898320 cites W2147289989 @default.
- W2575898320 cites W2148443098 @default.
- W2575898320 cites W2151960657 @default.
- W2575898320 cites W2157624856 @default.
- W2575898320 cites W2164542391 @default.
- W2575898320 cites W2165361187 @default.
- W2575898320 cites W2167821466 @default.
- W2575898320 cites W2170515647 @default.
- W2575898320 cites W2316852066 @default.