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• W2576153669 abstract "<p><span style=font-size: medium;><strong>Background: </strong>The majority of first cases of myocardial infarction stem from those classified as intermediate- or low-risk in CV risk prediction calculators. Risk prediction models need to be refined in their capacity to discriminate high-risk from low-risk. Peripheral arterial tonometry (PAT) is a non-invasive method to assess peripheral endothelial function that could potentially improve primary prevention of CVD. We investigated the relation of PAT results to CV risk factors and risk score in a healthy cohort.</span></p><p><span style=font-size: medium;><strong>Methods: </strong>PAT measurements were performed on 102 individuals, with no previous history of CAD, attending a Risk Preventive Clinic.<strong> </strong>Traditional CV risk factors were evaluated and integrated into a CV risk score calculator. Outcome was expressed as absolute and relative 10-year risk of developing CVD. </span></p><p><strong><span style=font-size: medium;>Results: </span></strong><span style=font-size: medium;>PAT results of reactive hyperemia index (RHI) and augmentation index (AI) had no statistically significant relation to risk score while baseline pulse amplitude was positively correlated with both absolute (<em>p </em>= 0.02) and relative (<em>p </em>= 0.02) 10-year risk of developing CVD. Among CV risk factors only heart rate was significantly associated with RHI (r = - 0.24, R</span>^{<span style=font-size: small;>2</span>}<span style=font-size: medium;> = 0.06, <em>p</em> = 0.01). AI and baseline pulse amplitude both correlated with several risk factors.</span></p><p><span style=font-size: medium;><strong>Conclusions: </strong>Endothelial dysfunction, as measured by PAT, was not associated with an increased 10-year risk of developing CVD. The relation between endothelial dysfunction and established CV risk factors was limited. Further clinical end point studies are needed to fully comprehend the diagnostic and predictive value of PAT measurements in healthy subjects.</span></p>" @default.
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• W2576153669 date "2017-01-14" @default.
• W2576153669 modified "2023-09-23" @default.
• W2576153669 title "Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects" @default.
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• W2576153669 doi "https://doi.org/10.17987/icfj.v9i0.385" @default.
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