FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2576543105> ?p ?o ?g. }

• W2576543105 endingPage "222" @default.
• W2576543105 startingPage "216" @default.
• W2576543105 abstract "BACKGROUND:The aim of this study was to detect the expression of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and estimate its diagnostic value in prostate cancer (PCa). MATERIAL AND METHODS:EFEMP1 expression in serum and urine of patients with PCa, benign controls and healthy controls at mRNA and protein level were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) analysis, respectively. The chi-square test was used to analyze the relationship between EFEMP1 expression and clinical factors of patients with PCa. A receiver operating characteristic (ROC) curve was established to evaluate the potential values of EFEMP1 for the diagnosis of PCa. RESULTS:The relative expression of EFEMP1 was significantly decreased in patients with PCa compared with that in the benign controls and healthy individuals, both at mRNA and protein levels (P<0.05). In the postoperative serum, the EFEMP1 expression was significantly higher than that in preoperative serum at 2 levels. Urine EFEMP1 expression was also down-regulated in patients with PCa compared to that in the other 2 control groups. The low expression of EFEMP1 was obviously affected by Gleason’s score, serum PSA, pathological stage, and lymph node metastasis. Moreover, there was a significant inverse correlation between EFEMP1 expression and PSA levels. The ROC curve revealed that EFEMP1 distinguished PCa patients from healthy controls, with a high AUC of 0.908, corresponding with high sensitivity and specificity, which was significantly higher than the PSA value. CONCLUSIONS:Serum EFEMP1 is down-regulated and involved in the progression of PCa. It may serve as a useful diagnostic biomarker, with better diagnostic accuracy than PSA in PCa." @default.
• W2576543105 created "2017-01-26" @default.
• W2576543105 creator A5022615064 @default.
• W2576543105 creator A5048322214 @default.
• W2576543105 creator A5051566101 @default.
• W2576543105 creator A5069508144 @default.
• W2576543105 creator A5075286349 @default.
• W2576543105 creator A5075510538 @default.
• W2576543105 creator A5083228843 @default.
• W2576543105 date "2017-01-13" @default.
• W2576543105 modified "2023-09-30" @default.
• W2576543105 title "Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 (EFEMP1) Acts as a Potential Diagnostic Biomarker for Prostate Cancer" @default.
• W2576543105 cites W1851252020 @default.
• W2576543105 cites W1964958632 @default.
• W2576543105 cites W1973537565 @default.
• W2576543105 cites W1998957301 @default.
• W2576543105 cites W2014725746 @default.
• W2576543105 cites W2019405416 @default.
• W2576543105 cites W2029236961 @default.
• W2576543105 cites W2033589655 @default.
• W2576543105 cites W2037531077 @default.
• W2576543105 cites W2045371528 @default.
• W2576543105 cites W2061913084 @default.
• W2576543105 cites W2062944205 @default.
• W2576543105 cites W2071596922 @default.
• W2576543105 cites W2082709973 @default.
• W2576543105 cites W2086878322 @default.
• W2576543105 cites W2095761465 @default.
• W2576543105 cites W2106703869 @default.
• W2576543105 cites W2109046819 @default.
• W2576543105 cites W2113915617 @default.
• W2576543105 cites W2129882531 @default.
• W2576543105 cites W2140278233 @default.
• W2576543105 cites W2146095818 @default.
• W2576543105 cites W2148785183 @default.
• W2576543105 cites W2149371894 @default.
• W2576543105 cites W2153114819 @default.
• W2576543105 cites W2156087087 @default.
• W2576543105 cites W2168033859 @default.
• W2576543105 cites W2175365136 @default.
• W2576543105 cites W2179472269 @default.
• W2576543105 cites W2235523093 @default.
• W2576543105 cites W2235954515 @default.
• W2576543105 cites W2321173770 @default.
• W2576543105 cites W2327750057 @default.
• W2576543105 cites W2413600973 @default.
• W2576543105 doi "https://doi.org/10.12659/msm.898809" @default.
• W2576543105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5256367" @default.
• W2576543105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28085790" @default.
• W2576543105 hasPublicationYear "2017" @default.
• W2576543105 type Work @default.
• W2576543105 sameAs 2576543105 @default.
• W2576543105 citedByCount "15" @default.
• W2576543105 countsByYear W25765431052017 @default.
• W2576543105 countsByYear W25765431052018 @default.
• W2576543105 countsByYear W25765431052019 @default.
• W2576543105 countsByYear W25765431052020 @default.
• W2576543105 countsByYear W25765431052022 @default.
• W2576543105 crossrefType "journal-article" @default.
• W2576543105 hasAuthorship W2576543105A5022615064 @default.
• W2576543105 hasAuthorship W2576543105A5048322214 @default.
• W2576543105 hasAuthorship W2576543105A5051566101 @default.
• W2576543105 hasAuthorship W2576543105A5069508144 @default.
• W2576543105 hasAuthorship W2576543105A5075286349 @default.
• W2576543105 hasAuthorship W2576543105A5075510538 @default.
• W2576543105 hasAuthorship W2576543105A5083228843 @default.
• W2576543105 hasBestOaLocation W25765431052 @default.
• W2576543105 hasConcept C121608353 @default.
• W2576543105 hasConcept C126322002 @default.
• W2576543105 hasConcept C143998085 @default.
• W2576543105 hasConcept C207886595 @default.
• W2576543105 hasConcept C2780192828 @default.
• W2576543105 hasConcept C2781197716 @default.
• W2576543105 hasConcept C55493867 @default.
• W2576543105 hasConcept C58471807 @default.
• W2576543105 hasConcept C71924100 @default.
• W2576543105 hasConcept C86803240 @default.
• W2576543105 hasConceptScore W2576543105C121608353 @default.
• W2576543105 hasConceptScore W2576543105C126322002 @default.
• W2576543105 hasConceptScore W2576543105C143998085 @default.
• W2576543105 hasConceptScore W2576543105C207886595 @default.
• W2576543105 hasConceptScore W2576543105C2780192828 @default.
• W2576543105 hasConceptScore W2576543105C2781197716 @default.
• W2576543105 hasConceptScore W2576543105C55493867 @default.
• W2576543105 hasConceptScore W2576543105C58471807 @default.
• W2576543105 hasConceptScore W2576543105C71924100 @default.
• W2576543105 hasConceptScore W2576543105C86803240 @default.
• W2576543105 hasLocation W25765431051 @default.
• W2576543105 hasLocation W25765431052 @default.
• W2576543105 hasLocation W25765431053 @default.
• W2576543105 hasLocation W25765431054 @default.
• W2576543105 hasOpenAccess W2576543105 @default.
• W2576543105 hasPrimaryLocation W25765431051 @default.
• W2576543105 hasRelatedWork W1150812590 @default.
• W2576543105 hasRelatedWork W2116211561 @default.
• W2576543105 hasRelatedWork W2161899978 @default.
• W2576543105 hasRelatedWork W2336130711 @default.
• W2576543105 hasRelatedWork W2345040638 @default.

• next