FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2576571660> ?p ?o ?g. }

• W2576571660 abstract "Abstract Over thirty types of lymphoma are now recognized and correct diagnosis is therefore essential. We have developed a novel approach, using arrays containing thousands of recombinant proteins (Bussow K, Cahill D, Nietfeld W et al. Nucleic Acids Res 1998 26:5007–8; Gutjahr C, Murphy D, Lueking A et al. Genomics 2005 85:285–96), to identify new potential disease markers in a number of different lymphomas. Specifically, by screening patient serum samples against human protein/antigen arrays containing over 10,000 different human proteins we are able to identify disease-associated auto-IgG antibody interactions (Horn S, Lueking A, Murphy D et al. Proteomics 2006 6:605–13). Our approach exploits the autoimmune response which has been observed in many cancer types. For example, patients with anaplastic large cell lymphoma (ALCL) produce circulating autoantibodies against the aberrantly expressed ALK tyrosine kinase (Pulford K, Falini B, Banham A et al. Blood 2000 96:1605–7; Ait-Tahar K, Hatton CSR, Banham A et al. Int J Cancer 2006 118:688–95). Also, patients suffering from follicular lymphoma (FL) have been shown to produce antibodies reactive with BCL-2 (Pulford K, Roberton H, Banham A et al. Br J Haematol 2002 116:135–41). In this study we are screening serum samples from patients with ALK-positive ALCL, ALK-negative ALCL, germinal center and non-germinal center subtypes of diffuse large B cell lymphoma (DLBCL), transformed DLBCL, peripheral T-cell lymphoma, mantle cell lymphoma and FL. Initially, a pool of 5 patient samples from each lymphoma type and a sex- and age-matched control group are screened against the antigen arrays. These experiments yield lists of putative disease-associated autoantigens. Screening larger numbers of individual serum samples from lymphoma patients and control cohorts against these autoantigens will enable an estimate of the frequency and disease specificity associated with circulating antibodies against each of the autoantigens identified. An initial study of 5 patients with ALK-positive ALCL, 5 patients with ALK-positive ALCL and 5 age- and sex-matched controls revealed the identification of 140 putative ALK-positive ALCL-associated autoantigens, 125 putative ALK-negative ALCL-associated autoantigens, and 27 autoantigens common to both ALK-positive and ALK-negative ALCL. We are currently ranking these results through individual screens of ALCL patient samples. We will also present the results obtained from the other 6 lymphoma types being screened, identifying autoantigens which show a disease-specific pattern, as well as those that are common to one or more of these lymphoma types. The approach described here should contribute not only towards the discovery of novel lymphoma markers, the discovery of potentially novel proteins involved in the development of the disease but also to the identification of therapeutic targets." @default.
• W2576571660 created "2017-01-26" @default.
• W2576571660 creator A5007540383 @default.
• W2576571660 creator A5008969451 @default.
• W2576571660 creator A5009891423 @default.
• W2576571660 creator A5011099952 @default.
• W2576571660 creator A5016957205 @default.
• W2576571660 creator A5021965002 @default.
• W2576571660 creator A5062349739 @default.
• W2576571660 creator A5066690325 @default.
• W2576571660 creator A5083764936 @default.
• W2576571660 creator A5084407097 @default.
• W2576571660 creator A5088712719 @default.
• W2576571660 date "2006-11-01" @default.
• W2576571660 modified "2023-09-26" @default.
• W2576571660 title "Identification of Circulating Autoantibodies in Patients with Lymphoma Using Antigen Arrays." @default.
• W2576571660 doi "https://doi.org/10.1182/blood.v108.11.2397.2397" @default.
• W2576571660 hasPublicationYear "2006" @default.
• W2576571660 type Work @default.
• W2576571660 sameAs 2576571660 @default.
• W2576571660 citedByCount "0" @default.
• W2576571660 crossrefType "journal-article" @default.
• W2576571660 hasAuthorship W2576571660A5007540383 @default.
• W2576571660 hasAuthorship W2576571660A5008969451 @default.
• W2576571660 hasAuthorship W2576571660A5009891423 @default.
• W2576571660 hasAuthorship W2576571660A5011099952 @default.
• W2576571660 hasAuthorship W2576571660A5016957205 @default.
• W2576571660 hasAuthorship W2576571660A5021965002 @default.
• W2576571660 hasAuthorship W2576571660A5062349739 @default.
• W2576571660 hasAuthorship W2576571660A5066690325 @default.
• W2576571660 hasAuthorship W2576571660A5083764936 @default.
• W2576571660 hasAuthorship W2576571660A5084407097 @default.
• W2576571660 hasAuthorship W2576571660A5088712719 @default.
• W2576571660 hasConcept C107006841 @default.
• W2576571660 hasConcept C117643217 @default.
• W2576571660 hasConcept C121608353 @default.
• W2576571660 hasConcept C126322002 @default.
• W2576571660 hasConcept C142724271 @default.
• W2576571660 hasConcept C147483822 @default.
• W2576571660 hasConcept C159654299 @default.
• W2576571660 hasConcept C163764329 @default.
• W2576571660 hasConcept C203014093 @default.
• W2576571660 hasConcept C2776232967 @default.
• W2576571660 hasConcept C2776256026 @default.
• W2576571660 hasConcept C2777058707 @default.
• W2576571660 hasConcept C2777525834 @default.
• W2576571660 hasConcept C2777872185 @default.
• W2576571660 hasConcept C2778453870 @default.
• W2576571660 hasConcept C2779338263 @default.
• W2576571660 hasConcept C502942594 @default.
• W2576571660 hasConcept C71924100 @default.
• W2576571660 hasConcept C96926380 @default.
• W2576571660 hasConceptScore W2576571660C107006841 @default.
• W2576571660 hasConceptScore W2576571660C117643217 @default.
• W2576571660 hasConceptScore W2576571660C121608353 @default.
• W2576571660 hasConceptScore W2576571660C126322002 @default.
• W2576571660 hasConceptScore W2576571660C142724271 @default.
• W2576571660 hasConceptScore W2576571660C147483822 @default.
• W2576571660 hasConceptScore W2576571660C159654299 @default.
• W2576571660 hasConceptScore W2576571660C163764329 @default.
• W2576571660 hasConceptScore W2576571660C203014093 @default.
• W2576571660 hasConceptScore W2576571660C2776232967 @default.
• W2576571660 hasConceptScore W2576571660C2776256026 @default.
• W2576571660 hasConceptScore W2576571660C2777058707 @default.
• W2576571660 hasConceptScore W2576571660C2777525834 @default.
• W2576571660 hasConceptScore W2576571660C2777872185 @default.
• W2576571660 hasConceptScore W2576571660C2778453870 @default.
• W2576571660 hasConceptScore W2576571660C2779338263 @default.
• W2576571660 hasConceptScore W2576571660C502942594 @default.
• W2576571660 hasConceptScore W2576571660C71924100 @default.
• W2576571660 hasConceptScore W2576571660C96926380 @default.
• W2576571660 hasLocation W25765716601 @default.
• W2576571660 hasOpenAccess W2576571660 @default.
• W2576571660 hasPrimaryLocation W25765716601 @default.
• W2576571660 hasRelatedWork W1501529729 @default.
• W2576571660 hasRelatedWork W1558285676 @default.
• W2576571660 hasRelatedWork W1896846513 @default.
• W2576571660 hasRelatedWork W2026358441 @default.
• W2576571660 hasRelatedWork W2132600682 @default.
• W2576571660 hasRelatedWork W2145601854 @default.
• W2576571660 hasRelatedWork W2363161528 @default.
• W2576571660 hasRelatedWork W2418926260 @default.
• W2576571660 hasRelatedWork W2583101676 @default.
• W2576571660 hasRelatedWork W2953751035 @default.
• W2576571660 isParatext "false" @default.
• W2576571660 isRetracted "false" @default.
• W2576571660 magId "2576571660" @default.
• W2576571660 workType "article" @default.