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- W2576862274 abstract "The aim of this study was to investigate the influence of 17ß-estradiol (E 2 ) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. Rats were divided into six groups as sham + saline, sham + single dose E 2 (SDE 2 ), sham + multiple dose E 2 (MDE 2 ), ANP + saline, ANP + SDE 2 , and ANP + MDE 2 . ANP in rats was induced by glycodeoxycholic acid. The extent of acinar cell injury, mortality, systemic cardiorespiratory variables, functional capillary density (FCD), renal/hepatic functions, and changes in some enzyme markers for pancreatic and lung tissue were investigated during ANP in rats. The induction of ANP resulted in a significant increase in the mortality rate, pancreatic necrosis, and serum activity of amylase, alanine aminotransferase (ALT), interleukin (IL)-6, lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, and tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and a significant decrease in concentrations of calcium, blood pressure, urine output, p0 2 , and functional capillary density (FCD). The use of E 2 did not alter these changes. E 2 demonstrated no effect on the course of ANP in rats. Therefore, it has no value in the treatment during acute pancreatitis." @default.
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- W2576862274 date "2013-09-01" @default.
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- W2576862274 title "Effects of 17ß-Estradiol on the Acute Necrotizing Pancreatitis after Onset in Rats" @default.
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- W2576862274 doi "https://doi.org/10.1177/1721727x1301100311" @default.
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