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• W2576906165 abstract "Introducao: Nos ultimos anos, tem havido relatos de anormalidades do fluxo sanguineo cerebral em individuos como abuso de cocaina, detectadas por meio de tomografia computadorizada por emissao de foton unico (SPECT). Essepadrao anormal de perfusao cerebral tem sido associado a prejuizos cognitivos mas nao a alteracoes observaveispor meio de exames de neuroimagem estrutural. Um problema envolvendo a maioria dos trabalhos publicados sobreesse tema e a inclusao de um grande numero de usuarios de heroina nas amostras estudadas. Essa outra drogatambem parece afetar o padrao de perfusao cerebral, particularmente durante estados de abstinencia.Metodos: Quatorze pacientes dependentes de cocaina (nenhum com uso de opioides) e 14 voluntarios normais (grupocontrole) foram submetidos a exames de SPECT com dimero de etil-cisteina marcado com tecnecio-99m. A analise dosexames de SPECT foi realizada por meio de analise visual qualitativa das imagens obtidas (procedimento padrao napratica clinica), realizada por um radiologista nao informado sobre o diagnostico dos individuos avaliados.Resultados: A analise visual revelou um padrao sugestivo de irregularidades do fluxo sanguineo cerebral emnove pacientes, mas em apenas dois controles (p = 0,018; teste exato de Fisher bicaudal).Conclusoes: Anormalidades de circulacao cerebral podem ter relacao com prejuizos cognitivos relatados empopulacoes de dependentes de cocaina. Embora deficits de perfusao cerebral associados ao uso de cocainapossam ser irreversiveis, tem surgido relatos na literatura de tratamentos para essas anormalidades de fluxosanguineo. Alteracoes de fluxo sanguineo cerebral associadas a dependencia de cocaina ocorrem mesmo naausencia de abuso ou dependencia de opioides.Cocaina. Crack. Abuso de substâncias. Fluxo sanguineo cerebral. SPECT.Introduction: In the last years, there have been reports of abnormalities in brain blood flow of cocaine abusers,detected by single photon computed emission tomography (SPECT). This abnormal pattern of brain perfusionhas been associated with cognitive impairments but not with changes that could be seen by the use of structuralneuroimaging techniques. One of the problems with most of the published papers on the subject is the inclusionof a large number of heroin users in the studied samples. Heroin also seems to affect the pattern of brainperfusion, particularly during withdrawal states.Methods: Fourteen cocaine-dependent inpatients (none of them under the use of opiates) and 14 healthy volunteers(control group) were submitted to 99m-technetium ethyl-cysteinate dimer SPECT. The analysis of SPECT examswas made by visual qualitative analysis of the reconstructed images (standard method in clinical practice),performed by a radiologist unaware of the subjects’ diagnoses.Results: Visual analysis showed a pattern suggestive of irregularities in the cerebral blood flow in nine patients,but in only two controls (p = 0.018; two tailed Fisher’s exact test).Conclusions: Abnormal brain circulation may be related to cognitive impairments reported in cocaine dependentsubjects. Although brain perfusion deficits associated with cocaine use may be irreversible, there have beenreports in the literature of treatments for these blood flow changes. There are abnormalities in the cerebral bloodflow associated with cocaine dependence even in the absence of opiate abuse or dependence.Cocaine. Crack. Substance abuse. Cerebral blood flow. SPECT.ResumoDescritoresAbstractKeywords" @default.
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• W2576906165 title "Anormalidades de fluxo sangüíneo cerebral em indivíduos dependentes de cocaína Cerebral blood flow abnormalities in cocaine dependent subjects" @default.
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