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• W2577030492 endingPage "425" @default.
• W2577030492 startingPage "403" @default.
• W2577030492 abstract "Melanogenesis is a process to synthesize melanin, which is a primary responsible for the pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and chemical reactions are involved in melanogenesis process, the enzymes such as tyrosinase and tyrosinase-related protein-1 (TRP-1) and TRP-2 played a major role in melanin synthesis. Specifically, tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin synthesis, and the downregulation of tyrosinase is the most prominent approach for the development of melanogenesis inhibitors. Therefore, numerous inhibitors that target tyrosinase have been developed in recent years. The review focuses on the recent discovery of tyrosinase inhibitors that are directly involved in the inhibition of tyrosinase catalytic activity and functionality from all sources, including laboratory synthetic methods, natural products, virtual screening and structure-based molecular docking studies." @default.
• W2577030492 created "2017-01-26" @default.
• W2577030492 creator A5017890506 @default.
• W2577030492 creator A5035696508 @default.
• W2577030492 creator A5061959920 @default.
• W2577030492 date "2017-01-01" @default.
• W2577030492 modified "2023-10-15" @default.
• W2577030492 title "Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors" @default.
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