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• W2577125086 endingPage "16.2017" @default.
• W2577125086 startingPage "ENEURO.0364" @default.
• W2577125086 abstract "Individuals with chronic pain may be driven to smoke more because the analgesic efficacy of nicotine diminishes. To determine whether persistent pain diminishes the actions of a nicotinic acetylcholine receptor (nAChR) agonist in pain modulatory pathways, we examined the effects of epibatidine in the rostral ventromedial medulla (RVM) of rats with and without inflammatory injury induced by intraplantar injection of complete Freund’s adjuvant (CFA). In uninjured rats, epibatidine produced a dose-dependent antinociception that was completely blocked by dihydro-β-erythroidine (DHβE; α4β2 antagonist) and partially blocked by methyllycaconitine (MLA; α7 antagonist). Epibatidine reversed heat hyperalgesia when microinjected in the RVM 4 h, 4 d, or 2 weeks after CFA treatment. Although DHβE completely blocked epibatidine’s antihyperalgesic effect at 4 h, at 2 weeks it elicited only partial antagonism. Methyllycaconitine was ineffective at both time points. Epibatidine’s antinociceptive efficacy in the uninjured hind paw progressively declined, and it was without effect 2 weeks after CFA. Moreover, as early as 4 h after CFA, the antinociceptive effect of epibatidine was no longer antagonized by DHβE. Neither antagonist alone altered paw withdrawal latency in uninjured or CFA-treated rats, suggesting that neither α4β2 nor α7 nAChRs are tonically active in the RVM. The B max and K d of α4β2 nAChRs in the RVM were unchanged after CFA treatment. These observations provide the first evidence of pharmacological plasticity of the actions of α4β2 nAChR agonists in a critical brainstem pain modulatory pathway and may in part explain why people with chronic pain smoke more than the general population." @default.
• W2577125086 created "2017-01-26" @default.
• W2577125086 creator A5028230383 @default.
• W2577125086 creator A5042390569 @default.
• W2577125086 creator A5087694465 @default.
• W2577125086 date "2017-01-01" @default.
• W2577125086 modified "2023-10-14" @default.
• W2577125086 title "Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat" @default.
• W2577125086 cites W1149803252 @default.
• W2577125086 cites W1540199296 @default.
• W2577125086 cites W1555114834 @default.
• W2577125086 cites W1619516058 @default.
• W2577125086 cites W1825194348 @default.
• W2577125086 cites W1885663309 @default.
• W2577125086 cites W1896321378 @default.
• W2577125086 cites W1904510297 @default.
• W2577125086 cites W1928871450 @default.
• W2577125086 cites W1936852202 @default.
• W2577125086 cites W1941827536 @default.
• W2577125086 cites W1965443085 @default.
• W2577125086 cites W1968111834 @default.
• W2577125086 cites W1972568160 @default.
• W2577125086 cites W1974958755 @default.
• W2577125086 cites W1976419305 @default.
• W2577125086 cites W1976792158 @default.
• W2577125086 cites W1978362518 @default.
• W2577125086 cites W1981291046 @default.
• W2577125086 cites W1982558275 @default.
• W2577125086 cites W1983069408 @default.
• W2577125086 cites W1984236031 @default.
• W2577125086 cites W1985048795 @default.
• W2577125086 cites W1986263340 @default.
• W2577125086 cites W1989069064 @default.
• W2577125086 cites W1990988036 @default.
• W2577125086 cites W1991537801 @default.
• W2577125086 cites W1999440593 @default.
• W2577125086 cites W2000300753 @default.
• W2577125086 cites W2000982560 @default.
• W2577125086 cites W2001220427 @default.
• W2577125086 cites W2004551214 @default.
• W2577125086 cites W2005834917 @default.
• W2577125086 cites W2008579253 @default.
• W2577125086 cites W2009174750 @default.
• W2577125086 cites W2012557125 @default.
• W2577125086 cites W2015734868 @default.
• W2577125086 cites W2017870121 @default.
• W2577125086 cites W2024616043 @default.
• W2577125086 cites W2029779306 @default.
• W2577125086 cites W2035064222 @default.
• W2577125086 cites W2035946761 @default.
• W2577125086 cites W2038995429 @default.
• W2577125086 cites W2049970203 @default.
• W2577125086 cites W2051379029 @default.
• W2577125086 cites W2053266420 @default.
• W2577125086 cites W2059848853 @default.
• W2577125086 cites W2060488758 @default.
• W2577125086 cites W2062700118 @default.
• W2577125086 cites W2065231072 @default.
• W2577125086 cites W2065498173 @default.
• W2577125086 cites W2074227215 @default.
• W2577125086 cites W2078150529 @default.
• W2577125086 cites W2079096246 @default.
• W2577125086 cites W2080939177 @default.
• W2577125086 cites W2085234856 @default.
• W2577125086 cites W2085316111 @default.
• W2577125086 cites W2090771267 @default.
• W2577125086 cites W2091231277 @default.
• W2577125086 cites W2104594197 @default.
• W2577125086 cites W2107757832 @default.
• W2577125086 cites W2109615265 @default.
• W2577125086 cites W2110183171 @default.
• W2577125086 cites W2116811577 @default.
• W2577125086 cites W2134952759 @default.
• W2577125086 cites W2135163605 @default.
• W2577125086 cites W2135654757 @default.
• W2577125086 cites W2136149147 @default.
• W2577125086 cites W2138109774 @default.
• W2577125086 cites W2138629151 @default.
• W2577125086 cites W2139802833 @default.
• W2577125086 cites W2140157123 @default.
• W2577125086 cites W2140445474 @default.
• W2577125086 cites W2141830709 @default.
• W2577125086 cites W2142268301 @default.
• W2577125086 cites W2147154002 @default.
• W2577125086 cites W2153466112 @default.
• W2577125086 cites W2159887246 @default.
• W2577125086 cites W2162068658 @default.
• W2577125086 cites W2262735881 @default.
• W2577125086 cites W2277618727 @default.
• W2577125086 cites W2317413711 @default.
• W2577125086 cites W2339495421 @default.
• W2577125086 cites W2415916294 @default.
• W2577125086 cites W4253949401 @default.
• W2577125086 cites W4285719527 @default.
• W2577125086 cites W4322703287 @default.
• W2577125086 doi "https://doi.org/10.1523/eneuro.0364-16.2017" @default.
• W2577125086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5286660" @default.
• W2577125086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28197544" @default.

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