FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2577143721> ?p ?o ?g. }

• W2577143721 endingPage "17920" @default.
• W2577143721 startingPage "17908" @default.
• W2577143721 abstract "// Yang Jiao 1, 2 , Bethany N. Hannafon 1 , Roy R. Zhang 1 , Kar-Ming Fung 1, 3 , Wei-Qun Ding 1, 3 1 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA 2 School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, P.R. China 3 Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA Correspondence to: Wei-Qun Ding, email: weiqun-ding@ouhsc.edu Keywords: docosahexaenoic acid, disulfiram, oxidative stress, nuclear factor (erythroid-derived 2)-like 2, cancer stem cell Received: June 17, 2016     Accepted: December 16, 2016     Published: January 17, 2017 ABSTRACT We previously reported a synergistic anticancer action of clioquinol and docosahexaenoic acid (DHA) in human cancer cells. However, clioquinol has been banned from the clinic due to its neurotoxicity. This study identified disulfiram (DSF) as a substitute compound to clioquinol, acting in concert with DHA to more effectively kill cancer cells and suppress tumor growth. Treatment with DSF and DHA induced greater apoptotic cell death and suppression of tumor growth in vitro and in vivo , as compared to DSF and DHA used alone. Mechanistic studies demonstrated that DSF enhances DHA-induced cellular oxidative stress as evidenced by up-regulation of Nrf2-mediated heme oxygenase 1 (HO-1) gene transcription. On the other hand, DHA was found to enhance DSF-induced suppression of mammosphere formation and stem cell frequency in a selected cancer model system, indicating that alterations to cancer cell stemness are involved in the combinatory anticancer action of DSF and DHA. Thus, DHA and DSF, both clinically approved drugs, act in concert to more effectively kill cancer cells. This combinatory action involves an enhancement of cellular oxidative stress and suppression of cancer cell stemness." @default.
• W2577143721 created "2017-01-26" @default.
• W2577143721 creator A5024671320 @default.
• W2577143721 creator A5030347346 @default.
• W2577143721 creator A5043275768 @default.
• W2577143721 creator A5047721884 @default.
• W2577143721 creator A5089982306 @default.
• W2577143721 date "2017-01-17" @default.
• W2577143721 modified "2023-10-18" @default.
• W2577143721 title "Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions" @default.
• W2577143721 cites W1491350259 @default.
• W2577143721 cites W1493421534 @default.
• W2577143721 cites W1575291677 @default.
• W2577143721 cites W1849056430 @default.
• W2577143721 cites W1918396699 @default.
• W2577143721 cites W1948830757 @default.
• W2577143721 cites W1964235217 @default.
• W2577143721 cites W1964341201 @default.
• W2577143721 cites W1968598018 @default.
• W2577143721 cites W1974801603 @default.
• W2577143721 cites W1985415914 @default.
• W2577143721 cites W1990001011 @default.
• W2577143721 cites W1996934444 @default.
• W2577143721 cites W2000021455 @default.
• W2577143721 cites W2003299546 @default.
• W2577143721 cites W2007369931 @default.
• W2577143721 cites W2014451016 @default.
• W2577143721 cites W2018362863 @default.
• W2577143721 cites W2019709536 @default.
• W2577143721 cites W2031756172 @default.
• W2577143721 cites W2032048503 @default.
• W2577143721 cites W2032830619 @default.
• W2577143721 cites W2038544220 @default.
• W2577143721 cites W2042873228 @default.
• W2577143721 cites W2043774635 @default.
• W2577143721 cites W2046791720 @default.
• W2577143721 cites W2047463366 @default.
• W2577143721 cites W2058376595 @default.
• W2577143721 cites W2064946335 @default.
• W2577143721 cites W2075619210 @default.
• W2577143721 cites W2076918724 @default.
• W2577143721 cites W2081049312 @default.
• W2577143721 cites W2090195784 @default.
• W2577143721 cites W2092853620 @default.
• W2577143721 cites W2097806194 @default.
• W2577143721 cites W2098400442 @default.
• W2577143721 cites W2102539723 @default.
• W2577143721 cites W2102746728 @default.
• W2577143721 cites W2119455109 @default.
• W2577143721 cites W2126136644 @default.
• W2577143721 cites W2135029153 @default.
• W2577143721 cites W2135925682 @default.
• W2577143721 cites W2139170022 @default.
• W2577143721 cites W2143595321 @default.
• W2577143721 cites W2143675498 @default.
• W2577143721 cites W2150567908 @default.
• W2577143721 cites W2180392647 @default.
• W2577143721 cites W2182655233 @default.
• W2577143721 cites W2182832918 @default.
• W2577143721 cites W2207660553 @default.
• W2577143721 cites W2246937068 @default.
• W2577143721 cites W2253833672 @default.
• W2577143721 cites W2262765066 @default.
• W2577143721 cites W2264588403 @default.
• W2577143721 cites W2289198228 @default.
• W2577143721 cites W2291212075 @default.
• W2577143721 cites W2329436773 @default.
• W2577143721 cites W2337094551 @default.
• W2577143721 cites W2338137957 @default.
• W2577143721 cites W2343590639 @default.
• W2577143721 cites W4235306250 @default.
• W2577143721 doi "https://doi.org/10.18632/oncotarget.14702" @default.
• W2577143721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5392296" @default.
• W2577143721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28107189" @default.
• W2577143721 hasPublicationYear "2017" @default.
• W2577143721 type Work @default.
• W2577143721 sameAs 2577143721 @default.
• W2577143721 citedByCount "22" @default.
• W2577143721 countsByYear W25771437212017 @default.
• W2577143721 countsByYear W25771437212018 @default.
• W2577143721 countsByYear W25771437212019 @default.
• W2577143721 countsByYear W25771437212020 @default.
• W2577143721 countsByYear W25771437212021 @default.
• W2577143721 countsByYear W25771437212022 @default.
• W2577143721 countsByYear W25771437212023 @default.
• W2577143721 crossrefType "journal-article" @default.
• W2577143721 hasAuthorship W2577143721A5024671320 @default.
• W2577143721 hasAuthorship W2577143721A5030347346 @default.
• W2577143721 hasAuthorship W2577143721A5043275768 @default.
• W2577143721 hasAuthorship W2577143721A5047721884 @default.
• W2577143721 hasAuthorship W2577143721A5089982306 @default.
• W2577143721 hasBestOaLocation W25771437211 @default.
• W2577143721 hasConcept C121608353 @default.
• W2577143721 hasConcept C126322002 @default.
• W2577143721 hasConcept C185592680 @default.
• W2577143721 hasConcept C190283241 @default.
• W2577143721 hasConcept C19038510 @default.
• W2577143721 hasConcept C2776151105 @default.

• next