FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2577161566> ?p ?o ?g. }

• W2577161566 endingPage "198" @default.
• W2577161566 startingPage "185" @default.
• W2577161566 abstract "Preeclampsia is an inflammatory disease with endothelial cell dysfunction that occurs via decreased endothelial nitric oxide synthase/nitric oxide (eNOS/NO) activity. Aspirin reduces the incidence of hypertensive pregnancy complications. However, the underlying mechanism has not been clearly explained. Here, we found that tumor necrosis factor (TNF)-α, microRNA (miR)-155, and eNOS levels as well as endothelial redox phenotype were differentially regulated in preeclamptic patients, implying the involvement of TNF-α- and redox signal-mediated miR-155 biogenesis and eNOS downregulation in the pathogenesis of preeclampsia. Aspirin prevented the TNF-α-mediated increase in miR-155 biogenesis and decreases in eNOS expression and NO/cGMP production in cultured human umbilical vein endothelial cells (HUVECs). Similar effects of aspirin were also observed in HUVECs treated with H2O2. The preventive effects of aspirin was associated with the inhibition of nuclear factor-κB (NF-κB)-dependent MIR155HG (miR-155 host gene) expression. Aspirin recovered the TNF-α-mediated decrease in wild-type, but not mutant, eNOS 3'-untranslated region reporter activity, whose effect was blocked by miR-155 mimic. Moreover, aspirin prevented TNF-α-mediated endothelial cell dysfunction associated with impaired vasorelaxation, angiogenesis, and trophoblast invasion, and the preventive effects were blocked by miR-155 mimic or an eNOS inhibitor. Aspirin rescued TNF-α-mediated eNOS downregulation coupled with endothelial dysfunction by inhibiting NF-κB-dependent transcriptional miR-155 biogenesis. Thus, the redox-sensitive NF-κB/miR-155/eNOS axis may be crucial in the pathogenesis of vascular disorders including preeclampsia." @default.
• W2577161566 created "2017-01-26" @default.
• W2577161566 creator A5006057664 @default.
• W2577161566 creator A5007226887 @default.
• W2577161566 creator A5008221735 @default.
• W2577161566 creator A5012404284 @default.
• W2577161566 creator A5012588325 @default.
• W2577161566 creator A5023671514 @default.
• W2577161566 creator A5024650465 @default.
• W2577161566 creator A5031963353 @default.
• W2577161566 creator A5033853018 @default.
• W2577161566 creator A5044241064 @default.
• W2577161566 creator A5053467080 @default.
• W2577161566 creator A5054586763 @default.
• W2577161566 creator A5057041803 @default.
• W2577161566 creator A5067392576 @default.
• W2577161566 creator A5073284312 @default.
• W2577161566 creator A5075257352 @default.
• W2577161566 creator A5076882757 @default.
• W2577161566 creator A5077659343 @default.
• W2577161566 date "2017-03-01" @default.
• W2577161566 modified "2023-10-16" @default.
• W2577161566 title "Aspirin prevents TNF-α-induced endothelial cell dysfunction by regulating the NF-κB-dependent miR-155/eNOS pathway: Role of a miR-155/eNOS axis in preeclampsia" @default.
• W2577161566 cites W1529433619 @default.
• W2577161566 cites W1737752540 @default.
• W2577161566 cites W1964750695 @default.
• W2577161566 cites W1968036856 @default.
• W2577161566 cites W1969736091 @default.
• W2577161566 cites W1973626130 @default.
• W2577161566 cites W1974545692 @default.
• W2577161566 cites W1977392344 @default.
• W2577161566 cites W1980130144 @default.
• W2577161566 cites W1981697660 @default.
• W2577161566 cites W1982391253 @default.
• W2577161566 cites W1984309244 @default.
• W2577161566 cites W1985526555 @default.
• W2577161566 cites W1991430317 @default.
• W2577161566 cites W1994768137 @default.
• W2577161566 cites W2004642074 @default.
• W2577161566 cites W2005995285 @default.
• W2577161566 cites W2010237936 @default.
• W2577161566 cites W2017481656 @default.
• W2577161566 cites W2024340931 @default.
• W2577161566 cites W2026499164 @default.
• W2577161566 cites W2032524048 @default.
• W2577161566 cites W2039350598 @default.
• W2577161566 cites W2044451058 @default.
• W2577161566 cites W2052371470 @default.
• W2577161566 cites W2053216932 @default.
• W2577161566 cites W2072560041 @default.
• W2577161566 cites W2079983946 @default.
• W2577161566 cites W2084622404 @default.
• W2577161566 cites W2087477500 @default.
• W2577161566 cites W2090332907 @default.
• W2577161566 cites W2091193879 @default.
• W2577161566 cites W2097571046 @default.
• W2577161566 cites W2100144952 @default.
• W2577161566 cites W2100155786 @default.
• W2577161566 cites W2104895343 @default.
• W2577161566 cites W2109212247 @default.
• W2577161566 cites W2111074132 @default.
• W2577161566 cites W2111778724 @default.
• W2577161566 cites W2112164432 @default.
• W2577161566 cites W2116749190 @default.
• W2577161566 cites W2126990549 @default.
• W2577161566 cites W2132961242 @default.
• W2577161566 cites W2133586647 @default.
• W2577161566 cites W2137071089 @default.
• W2577161566 cites W2143180984 @default.
• W2577161566 cites W2145570729 @default.
• W2577161566 cites W2147853742 @default.
• W2577161566 cites W2160230584 @default.
• W2577161566 cites W2162985177 @default.
• W2577161566 cites W2165445226 @default.
• W2577161566 cites W2167515138 @default.
• W2577161566 cites W2275204317 @default.
• W2577161566 cites W2285613511 @default.
• W2577161566 cites W2329173933 @default.
• W2577161566 cites W3094019887 @default.
• W2577161566 doi "https://doi.org/10.1016/j.freeradbiomed.2017.01.010" @default.
• W2577161566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28087411" @default.
• W2577161566 hasPublicationYear "2017" @default.
• W2577161566 type Work @default.
• W2577161566 sameAs 2577161566 @default.
• W2577161566 citedByCount "103" @default.
• W2577161566 countsByYear W25771615662017 @default.
• W2577161566 countsByYear W25771615662018 @default.
• W2577161566 countsByYear W25771615662019 @default.
• W2577161566 countsByYear W25771615662020 @default.
• W2577161566 countsByYear W25771615662021 @default.
• W2577161566 countsByYear W25771615662022 @default.
• W2577161566 countsByYear W25771615662023 @default.
• W2577161566 crossrefType "journal-article" @default.
• W2577161566 hasAuthorship W2577161566A5006057664 @default.
• W2577161566 hasAuthorship W2577161566A5007226887 @default.
• W2577161566 hasAuthorship W2577161566A5008221735 @default.
• W2577161566 hasAuthorship W2577161566A5012404284 @default.
• W2577161566 hasAuthorship W2577161566A5012588325 @default.

• next