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- W2577173518 endingPage "e0170018" @default.
- W2577173518 startingPage "e0170018" @default.
- W2577173518 abstract "Brain atrophy is an important feature of many neurodegenerative disorders. It can be described in terms of change in the brain parenchymal fraction (BPF). In order to interpret the BPF in disease, knowledge on the BPF in healthy individuals is required. The aim of this study was to establish a normal range of values for the BPF of healthy individuals via a systematic review of the literature. The databases PubMed and Scopus were searched and 95 articles, including a total of 9269 individuals, were identified including the required data. We present values of BPF from healthy individuals stratified by age and post-processing method. The mean BPF correlated with mean age and there were significant differences in age-adjusted mean BPF between methods. This study contributes to increased knowledge about BPF in healthy individuals, which may assist in the interpretation of BPF in the setting of disease. We highlight the differences between post-processing methods and the need for a consensus gold standard." @default.
- W2577173518 created "2017-01-26" @default.
- W2577173518 creator A5012945005 @default.
- W2577173518 creator A5066248861 @default.
- W2577173518 creator A5085063312 @default.
- W2577173518 date "2017-01-17" @default.
- W2577173518 modified "2023-10-14" @default.
- W2577173518 title "Brain Parenchymal Fraction in Healthy Adults—A Systematic Review of the Literature" @default.
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