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• W2577671479 abstract "In response to environments that cause cellular stress, animals engage in sleep behavior that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep(SIS) is regulated by cytokine activation of the ALA neuron, which releases FLP-13 neuropeptides characterized by an amidated arginine-phenylalanine (RFamide) C-terminus motif. By performing an unbiased genetic screen for mutants that impair the somnogenic effects of FLP-13 neuropeptides, we identified the gene dmsr-1, which encodes a G-protein coupled receptor similar to an insect RFamide receptor. DMSR-1 is activated by FLP-13 peptides in cell culture, is required for SIS in vivo, is expressed non-synaptically in several wake-promoting neurons, and likely couples to a Gi/o heterotrimeric G-protein. Our data expand our understanding of how a single neuroendocrine cell coordinates an organism-wide behavioral response, and suggest that similar signaling principles may function in other organisms to regulate sleep during sickness." @default.
• W2577671479 created "2017-01-26" @default.
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• W2577671479 date "2017-01-17" @default.
• W2577671479 modified "2023-10-13" @default.
• W2577671479 title "The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans" @default.
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• W2577671479 doi "https://doi.org/10.7554/elife.19837" @default.
• W2577671479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5241116" @default.
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