FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2577671990> ?p ?o ?g. }

• W2577671990 endingPage "476" @default.
• W2577671990 startingPage "467" @default.
• W2577671990 abstract "Lymphatic vessels are important for maintenance of tissue fluid homeostasis and afferent antigen transport. In chronic inflammation, lymphangiogenesis takes place and is characterized by lymphatic endothelial cell proliferation and lymphatic hyperplasia. Vascular endothelial growth factor C (VEGFC) is the main known lymphangiogenic growth factor, and its expression is increased in periodontitis, a common chronic infectious disease that results in tissue destruction and alveolar bone loss. The role of lymphangiogenesis during development of periodontitis is unknown. Here, we test if transgenic overexpression of epithelial VEGFC in a murine model is followed by hyperplasia of lymphatic vessels in oral mucosa and if the lymphatic drainage capacity is altered. We also test if lymphatic hyperplasia protects against periodontal disease development. Transgenic keratin 14 (K14)–VEGFC mice had significant hyperplasia of lymphatics in oral mucosa, including gingiva, without changes in blood vessel vasculature. The basal lymph flow was normal but slightly lower than in wild-type mice when oral mucosa was challenged with lipopolysaccharide from Porphyromonas gingivalis. Under normal conditions, K14-VEGFC mice exhibited an increased number of neutrophils in gingiva, demonstrated enhanced phagocyte recruitment in the cervical lymph nodes, and had more alveolar bone when compared with their wild-type littermates. After induction of periodontitis, no strain differences were observed in the periodontal tissues with respect to granulocyte recruitment, bone resorption, angiogenesis, cytokines, and bone-related protein expressions or in draining lymph node immune cell proportions and vascularization. We conclude that overexpression of VEGFC results in hyperplastic lymphatics, which do not enhance lymphatic drainage capacity but facilitate phagocyte transport to draining lymph nodes. Hyperplasia of lymphatics does not protect against development of ligature-induced periodontitis." @default.
• W2577671990 created "2017-01-26" @default.
• W2577671990 creator A5016308459 @default.
• W2577671990 creator A5017154970 @default.
• W2577671990 creator A5020522312 @default.
• W2577671990 creator A5031475469 @default.
• W2577671990 creator A5070797699 @default.
• W2577671990 creator A5089005519 @default.
• W2577671990 date "2017-01-12" @default.
• W2577671990 modified "2023-09-24" @default.
• W2577671990 title "Role of Hyperplasia of Gingival Lymphatics in Periodontal Inflammation" @default.
• W2577671990 cites W1527522386 @default.
• W2577671990 cites W1605416285 @default.
• W2577671990 cites W1925706324 @default.
• W2577671990 cites W1945428372 @default.
• W2577671990 cites W1983704825 @default.
• W2577671990 cites W1988546348 @default.
• W2577671990 cites W1992138824 @default.
• W2577671990 cites W1992532574 @default.
• W2577671990 cites W2003794908 @default.
• W2577671990 cites W2015470185 @default.
• W2577671990 cites W2021838232 @default.
• W2577671990 cites W2023052504 @default.
• W2577671990 cites W2026487158 @default.
• W2577671990 cites W2038191439 @default.
• W2577671990 cites W2053785317 @default.
• W2577671990 cites W2056073729 @default.
• W2577671990 cites W2062512637 @default.
• W2577671990 cites W2081325361 @default.
• W2577671990 cites W2092088523 @default.
• W2577671990 cites W2093730925 @default.
• W2577671990 cites W2101416440 @default.
• W2577671990 cites W2108596538 @default.
• W2577671990 cites W2115352852 @default.
• W2577671990 cites W2162008869 @default.
• W2577671990 cites W2171543828 @default.
• W2577671990 cites W2222331351 @default.
• W2577671990 cites W2263813704 @default.
• W2577671990 cites W2346379636 @default.
• W2577671990 cites W2521261587 @default.
• W2577671990 cites W796960350 @default.
• W2577671990 doi "https://doi.org/10.1177/0022034516681762" @default.
• W2577671990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28081372" @default.
• W2577671990 hasPublicationYear "2017" @default.
• W2577671990 type Work @default.
• W2577671990 sameAs 2577671990 @default.
• W2577671990 citedByCount "10" @default.
• W2577671990 countsByYear W25776719902017 @default.
• W2577671990 countsByYear W25776719902018 @default.
• W2577671990 countsByYear W25776719902019 @default.
• W2577671990 countsByYear W25776719902020 @default.
• W2577671990 countsByYear W25776719902021 @default.
• W2577671990 countsByYear W25776719902023 @default.
• W2577671990 crossrefType "journal-article" @default.
• W2577671990 hasAuthorship W2577671990A5016308459 @default.
• W2577671990 hasAuthorship W2577671990A5017154970 @default.
• W2577671990 hasAuthorship W2577671990A5020522312 @default.
• W2577671990 hasAuthorship W2577671990A5031475469 @default.
• W2577671990 hasAuthorship W2577671990A5070797699 @default.
• W2577671990 hasAuthorship W2577671990A5089005519 @default.
• W2577671990 hasConcept C103041312 @default.
• W2577671990 hasConcept C121608353 @default.
• W2577671990 hasConcept C126322002 @default.
• W2577671990 hasConcept C142724271 @default.
• W2577671990 hasConcept C146285616 @default.
• W2577671990 hasConcept C167734588 @default.
• W2577671990 hasConcept C181152851 @default.
• W2577671990 hasConcept C203014093 @default.
• W2577671990 hasConcept C2776636583 @default.
• W2577671990 hasConcept C2776914184 @default.
• W2577671990 hasConcept C2777025900 @default.
• W2577671990 hasConcept C2779013556 @default.
• W2577671990 hasConcept C2779338263 @default.
• W2577671990 hasConcept C2780117679 @default.
• W2577671990 hasConcept C2780385504 @default.
• W2577671990 hasConcept C2910366181 @default.
• W2577671990 hasConcept C71924100 @default.
• W2577671990 hasConceptScore W2577671990C103041312 @default.
• W2577671990 hasConceptScore W2577671990C121608353 @default.
• W2577671990 hasConceptScore W2577671990C126322002 @default.
• W2577671990 hasConceptScore W2577671990C142724271 @default.
• W2577671990 hasConceptScore W2577671990C146285616 @default.
• W2577671990 hasConceptScore W2577671990C167734588 @default.
• W2577671990 hasConceptScore W2577671990C181152851 @default.
• W2577671990 hasConceptScore W2577671990C203014093 @default.
• W2577671990 hasConceptScore W2577671990C2776636583 @default.
• W2577671990 hasConceptScore W2577671990C2776914184 @default.
• W2577671990 hasConceptScore W2577671990C2777025900 @default.
• W2577671990 hasConceptScore W2577671990C2779013556 @default.
• W2577671990 hasConceptScore W2577671990C2779338263 @default.
• W2577671990 hasConceptScore W2577671990C2780117679 @default.
• W2577671990 hasConceptScore W2577671990C2780385504 @default.
• W2577671990 hasConceptScore W2577671990C2910366181 @default.
• W2577671990 hasConceptScore W2577671990C71924100 @default.
• W2577671990 hasIssue "4" @default.
• W2577671990 hasLocation W25776719901 @default.
• W2577671990 hasLocation W25776719902 @default.
• W2577671990 hasOpenAccess W2577671990 @default.

• next