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• W2577884818 abstract "Diospyros lotus L. possesses different therapeutic activities such as antioxidant, anti-proliferative, anti-microbial and sedative. However, no studies on the sedative-hypnotic activity of 7-methyljuglone are reported. In the present study, we have evaluated in vivo the anxiolytic-hypnotic like effects of 7-methyljuglone in mice with open field and phenobarbitone-induced sleeping time tests. We have also assessed in silico the involvement of GABAA, GABAB and 5HT1 neurotransmission in its mechanism of action. The intraperitoneal administration of 7-methyljuglone (2.5-10mg/kg) reduce significantly the number of crossed lines in mice open field test and concomitantly it shown a significant activity in term of onset of sleeping time and also in its duration. Moreover, 7-methyljuglone demonstrated in silico an interesting interaction with GABAA but not GABAB and 5HT1binding sites. All of these results, taken together, 7-methyljuglone may be an innovative candidate for designing new pharmaceutical and therapeutic applications." @default.
• W2577884818 created "2017-01-26" @default.
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• W2577884818 date "2017-03-01" @default.
• W2577884818 modified "2023-09-30" @default.
• W2577884818 title "In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L." @default.
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• W2577884818 doi "https://doi.org/10.1016/j.biopha.2017.01.021" @default.
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