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- W2578002151 abstract "PKN2, a member of the protein kinase N (PKN) family, has been suggested by in vitro culture cell experiments to bind to Rho/Rac GTPases and contributes to cell-cell contact and cell migration. To unravel the in vivo physiological function of PKN2, we targeted the PKN2 gene. Constitutive disruption of the mouse PKN2 gene resulted in growth retardation and lethality before embryonic day (E) 10.5. PKN2-/- embryo did not undergo axial turning and showed insufficient closure of the neural tube. Mouse embryonic fibroblasts (MEFs) derived from PKN2-/- embryos at E9.5 failed to grow. Cre-mediated ablation of PKN2 in PKN2flox/flox MEFs obtained from E14.5 embryos showed impaired cell proliferation, and cell cycle analysis of these MEFs showed a decrease in S-phase population. Our results show that PKN2 is essential for mouse embryonic development and cell-autonomous proliferation of primary MEFs in culture. Comparison of the PKN2-/- phenotype with the phenotypes of PKN1 and PKN3 knockout strains suggests that PKN2 has distinct nonredundant functions in vivo, despite the structural similarity and evolutionary relationship among the three isoforms." @default.
- W2578002151 created "2017-01-26" @default.
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- W2578002151 date "2017-01-19" @default.
- W2578002151 modified "2023-09-26" @default.
- W2578002151 title "PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts" @default.
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- W2578002151 cites W1968047653 @default.
- W2578002151 cites W1971695868 @default.
- W2578002151 cites W1975448725 @default.
- W2578002151 cites W1976770692 @default.
- W2578002151 cites W1982902233 @default.
- W2578002151 cites W1986383962 @default.
- W2578002151 cites W1987509690 @default.
- W2578002151 cites W1990052258 @default.
- W2578002151 cites W1990164081 @default.
- W2578002151 cites W1992817109 @default.
- W2578002151 cites W2004736524 @default.
- W2578002151 cites W2004926623 @default.
- W2578002151 cites W2009096862 @default.
- W2578002151 cites W2013564453 @default.
- W2578002151 cites W2015239877 @default.
- W2578002151 cites W2019335957 @default.
- W2578002151 cites W2019826954 @default.
- W2578002151 cites W2021046324 @default.
- W2578002151 cites W2038424997 @default.
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- W2578002151 cites W2055917628 @default.
- W2578002151 cites W2056158543 @default.
- W2578002151 cites W2056528345 @default.
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- W2578002151 cites W2061482218 @default.
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- W2578002151 cites W2082557203 @default.
- W2578002151 cites W2082978552 @default.
- W2578002151 cites W2085544097 @default.
- W2578002151 cites W2087172814 @default.
- W2578002151 cites W2087515287 @default.
- W2578002151 cites W2088603460 @default.
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- W2578002151 cites W2168137103 @default.
- W2578002151 cites W2171616938 @default.
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- W2578002151 doi "https://doi.org/10.1111/gtc.12470" @default.
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