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• W2578098817 abstract "One of the pathogenic mechanisms of the progression non-alcoholic liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) is the accumulation of reactive oxygen species (ROS). So, antioxidant therapy is necessary for successful treatment of the liver injury. We have paid attention to melanin produced by yeast Nadsoniella nigra strain X-1 as novel antioxidant and anti-inflammatory agents with low toxicity. In current study we aimed to investigate the preventive effect of melanin on the monosodium glutamate (MSG) induced NAFLD model in rats. The study was carried out on 45 Wistar rats that were divided into 3 groups: intact, MSG- and MSG + melanin groups (n = 15 in each group). Newborn rats of MSG- and MSG + melanin groups were administered with MSG (4 mg/g, 8 μl/g, subcutaneously) at 2nd–10th days of life. Since the age of 1 month, rats of MSG-group were treated with water (0.25 ml/100 g), rats of MSG + melanin groups—with melanin (1 mg/kg) dissolved in water (0.25 ml/100 g). had been performed intermittently (two-week courses alternated with two-week breaks) for 3 months. In 4-month rats anthropometrical parameters and visceral adipose tissue (VAT) mass were estimated. To assess morphological changes in liver we used NAS (NAFLD activity score). The content of pro-inflammatory cytokines (interleukin (IL)-1β, IL-12Bp40, interferon (INF)-γ) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor (TGF)-β) were measured by ELISA. We found significantly lower total score (1.0 ± 0.19 vs 3.33 ± 0.36, p < 0.001), degree of steatosis (0.73 ± 0.18 vs 1.80 ± 0.17, p < 0.001) and manifestation of lobular inflammation (0.27 ± 0.11 vs 1.20 ± 0.17, p < 0.001) due to NAFLD activity score in MSG + melanin group compared to MSG-obesity. NASH we confirmed only in 33.3% of rats with MSG-obesity that was significantly higher than after melanin (6.7%) administration (p = 0.033). Melanin administration reduce amount of visceral fat on 44.5% (p < 0.001) as compared to MSG-obesity group. Melanin reduced the content of IL-1β in rat serum and restored the level of anti-inflammatory cytokines (IL-10, TGF-β) to the control values. Thus, the administration of melanin can prevent development of NAFLD/NASH in rats with MSG-induced obesity and can be considered as possible novel therapeutic agents but further studies to confirm its action needed." @default.
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• W2578098817 date "2017-04-01" @default.
• W2578098817 modified "2023-10-15" @default.
• W2578098817 title "Effects of polyphenol compounds melanin on NAFLD/NASH prevention" @default.
• W2578098817 cites W1520430342 @default.
• W2578098817 cites W1850860196 @default.
• W2578098817 cites W1976245830 @default.
• W2578098817 cites W1979423929 @default.
• W2578098817 cites W1982653993 @default.
• W2578098817 cites W1984180526 @default.
• W2578098817 cites W1985468415 @default.
• W2578098817 cites W1985982307 @default.
• W2578098817 cites W1987052942 @default.
• W2578098817 cites W1993548467 @default.
• W2578098817 cites W1997542501 @default.
• W2578098817 cites W1998002161 @default.
• W2578098817 cites W2000170084 @default.
• W2578098817 cites W2002695088 @default.
• W2578098817 cites W2020055953 @default.
• W2578098817 cites W2025106732 @default.
• W2578098817 cites W2028098415 @default.
• W2578098817 cites W2030297437 @default.
• W2578098817 cites W2031882974 @default.
• W2578098817 cites W2041856925 @default.
• W2578098817 cites W2042107619 @default.
• W2578098817 cites W2045157582 @default.
• W2578098817 cites W2045357865 @default.
• W2578098817 cites W2045632404 @default.
• W2578098817 cites W2047257800 @default.
• W2578098817 cites W2051736442 @default.
• W2578098817 cites W2052931002 @default.
• W2578098817 cites W2055552977 @default.
• W2578098817 cites W2062336519 @default.
• W2578098817 cites W2064207652 @default.
• W2578098817 cites W2066168649 @default.
• W2578098817 cites W2067740038 @default.
• W2578098817 cites W2073801053 @default.
• W2578098817 cites W2073962547 @default.
• W2578098817 cites W2078496896 @default.
• W2578098817 cites W2079354947 @default.
• W2578098817 cites W2083350934 @default.
• W2578098817 cites W2084521532 @default.
• W2578098817 cites W2090028777 @default.
• W2578098817 cites W2095543599 @default.
• W2578098817 cites W2103195473 @default.
• W2578098817 cites W2108576543 @default.
• W2578098817 cites W2119171992 @default.
• W2578098817 cites W2119220075 @default.
• W2578098817 cites W2122638636 @default.
• W2578098817 cites W2135009079 @default.
• W2578098817 cites W2140509980 @default.
• W2578098817 cites W2144178804 @default.
• W2578098817 cites W2155992491 @default.
• W2578098817 cites W2157427421 @default.
• W2578098817 cites W2157844941 @default.
• W2578098817 cites W2157975994 @default.
• W2578098817 cites W2160902451 @default.
• W2578098817 cites W2165592417 @default.
• W2578098817 cites W2165623186 @default.
• W2578098817 cites W2167327064 @default.
• W2578098817 cites W2210672989 @default.
• W2578098817 cites W2276108661 @default.
• W2578098817 cites W2285227042 @default.
• W2578098817 cites W2302089850 @default.
• W2578098817 cites W2302968593 @default.
• W2578098817 cites W2319592808 @default.
• W2578098817 cites W2340948073 @default.
• W2578098817 cites W2514873437 @default.
• W2578098817 cites W4249375967 @default.
• W2578098817 cites W4249727000 @default.
• W2578098817 cites W72976067 @default.
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• W2578098817 doi "https://doi.org/10.1016/j.biopha.2017.01.028" @default.
• W2578098817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28110193" @default.
• W2578098817 hasPublicationYear "2017" @default.
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