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- W257816 abstract "Prostaglandin metabolism was used as a marker of one of the non-respiratory functions of the lung, and the metabolism of prostaglandin E2 was found to be inhibited by exposure to NO2 concentrations as low 0.2 ppm in a dose related manner up to 19 ppm. Recovery of inhibition following a single exposure to NO2 for 3 hours was also dose-related and required over 160 hours for recovery after exposure to 19 ppm. The lung is also capable of metabolizing a wide variety of xenobiotic compounds including polycyclic aromatic hydrocarbons. Experiments in isolated ventilated and perfused lungs indicate that this metabolism is dependent upon the availability of reducing equivalents. Nitrogen dioxide may significantly alter the availability of these reducing equivalents through action on lung enzymes supplying NADH and NADPH. Thus, nitrogen dioxide exposure at ambient concentrations may have two effects: The first being the death of specific cells within the lung as evidenced by inhibition of non-respiratory functions of the lung and the second being alterations in the metabolism of a variety of xenobiotic compounds. Other, as yet uninvestigated, non-respiratory functions may likewise be effected. These functions of the lung are not only useful markers of injury but also potential mechanisms of pulmonary pathogenesis." @default.
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- W257816 date "1982-01-01" @default.
- W257816 modified "2023-10-16" @default.
- W257816 title "Non-Respiratory Functions of the Lung: Pharmacological Effects" @default.
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- W257816 doi "https://doi.org/10.1016/b978-0-444-42127-2.50041-5" @default.
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