FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2578256220> ?p ?o ?g. }

• W2578256220 abstract "Recent studies have shown that early antiretroviral therapy (ART) initiation results in significant HIV transmission reduction. This is the rationale behind the “test and treat” policy of the World Health Organization (WHO). Implementation of this policy will lead to an increased incidence of ART-related adverse effects, especially in sub-Saharan Africa (SSA). Is the region yet ready to cope with such a challenging issue? The introduction and widespread use of ART have drastically changed the natural history of HIV/AIDS, but exposure to ART leads to serious medication-related adverse effects mainly explained by mitochondrial toxicities, and the situation will get worse in the near future. Indeed, ART is associated with an increased risk of developing cardiovascular disease, lipodystrophy, prediabetes and overt diabetes, insulin resistance and hyperlactatemia/lactic acidosis. The prevalence of these disorders is already high in SSA, and the situation will be exacerbated by the implementation of the new WHO recommendations. Most SSA countries are characterized by (extreme) poverty, very weak health systems, inadequate and low quality of health services, inaccessibility to existing health facilities, lack of (qualified) health personnel, lack of adequate equipment, inaccessibility and unaffordability of medicines, and heavy workload in a context of a double burden of disease. Additionally, there is dearth of data on the incidence and predictive factors of ART-related adverse effects in SSA, to anticipate on strategies that should be put in place to prevent the occurrence of these conditions or properly estimate the upcoming burden and prepare an adequate response plan. These are required if we are to anticipate and effectively prevent this upcoming burden. While SSA would be the first region to experience the huge benefits of implementing the “test and treat” policy of the WHO, the region is not yet prepared to manage the consequential increased burden of ART-related toxic and metabolic complications. Urgent measures should be taken to fill the lacunae if SSA is not to become over-burdened by the consequences of the “test and treat” policy." @default.
• W2578256220 created "2017-01-26" @default.
• W2578256220 creator A5039774231 @default.
• W2578256220 creator A5064531801 @default.
• W2578256220 date "2017-02-15" @default.
• W2578256220 modified "2023-10-17" @default.
• W2578256220 title "Antiretroviral therapy related adverse effects: Can sub-Saharan Africa cope with the new “test and treat” policy of the World Health Organization?" @default.
• W2578256220 cites W1828330334 @default.
• W2578256220 cites W1972696131 @default.
• W2578256220 cites W1973858656 @default.
• W2578256220 cites W1981476772 @default.
• W2578256220 cites W2008501988 @default.
• W2578256220 cites W2024163727 @default.
• W2578256220 cites W2046063669 @default.
• W2578256220 cites W2047787307 @default.
• W2578256220 cites W2062462390 @default.
• W2578256220 cites W2065258003 @default.
• W2578256220 cites W2068260044 @default.
• W2578256220 cites W2083801150 @default.
• W2578256220 cites W2098082628 @default.
• W2578256220 cites W2101070029 @default.
• W2578256220 cites W2105905549 @default.
• W2578256220 cites W2106779088 @default.
• W2578256220 cites W2108466541 @default.
• W2578256220 cites W2116560165 @default.
• W2578256220 cites W2117659981 @default.
• W2578256220 cites W2128879707 @default.
• W2578256220 cites W2138139979 @default.
• W2578256220 cites W2142474096 @default.
• W2578256220 cites W2144807644 @default.
• W2578256220 cites W2148857774 @default.
• W2578256220 cites W2160706548 @default.
• W2578256220 cites W2160970334 @default.
• W2578256220 cites W2174734039 @default.
• W2578256220 cites W2180009385 @default.
• W2578256220 cites W2190975103 @default.
• W2578256220 cites W2209195511 @default.
• W2578256220 cites W2209222401 @default.
• W2578256220 cites W2215220781 @default.
• W2578256220 cites W2238552371 @default.
• W2578256220 cites W2306374695 @default.
• W2578256220 cites W2331401273 @default.
• W2578256220 cites W2337899577 @default.
• W2578256220 cites W2403671454 @default.
• W2578256220 cites W2429410418 @default.
• W2578256220 cites W2464127715 @default.
• W2578256220 cites W2467355390 @default.
• W2578256220 cites W2514541874 @default.
• W2578256220 cites W2520408419 @default.
• W2578256220 cites W2520961380 @default.
• W2578256220 cites W61607843 @default.
• W2578256220 doi "https://doi.org/10.1186/s40249-017-0240-3" @default.
• W2578256220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5310075" @default.
• W2578256220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28196511" @default.
• W2578256220 hasPublicationYear "2017" @default.
• W2578256220 type Work @default.
• W2578256220 sameAs 2578256220 @default.
• W2578256220 citedByCount "29" @default.
• W2578256220 countsByYear W25782562202017 @default.
• W2578256220 countsByYear W25782562202018 @default.
• W2578256220 countsByYear W25782562202019 @default.
• W2578256220 countsByYear W25782562202020 @default.
• W2578256220 countsByYear W25782562202021 @default.
• W2578256220 countsByYear W25782562202022 @default.
• W2578256220 countsByYear W25782562202023 @default.
• W2578256220 crossrefType "journal-article" @default.
• W2578256220 hasAuthorship W2578256220A5039774231 @default.
• W2578256220 hasAuthorship W2578256220A5064531801 @default.
• W2578256220 hasBestOaLocation W25782562201 @default.
• W2578256220 hasConcept C126322002 @default.
• W2578256220 hasConcept C134018914 @default.
• W2578256220 hasConcept C138816342 @default.
• W2578256220 hasConcept C142462285 @default.
• W2578256220 hasConcept C142724271 @default.
• W2578256220 hasConcept C151730666 @default.
• W2578256220 hasConcept C159110408 @default.
• W2578256220 hasConcept C177713679 @default.
• W2578256220 hasConcept C197934379 @default.
• W2578256220 hasConcept C2777180221 @default.
• W2578256220 hasConcept C2779134260 @default.
• W2578256220 hasConcept C2779343474 @default.
• W2578256220 hasConcept C2779668308 @default.
• W2578256220 hasConcept C2780941825 @default.
• W2578256220 hasConcept C2909186138 @default.
• W2578256220 hasConcept C2993143319 @default.
• W2578256220 hasConcept C3013748606 @default.
• W2578256220 hasConcept C512399662 @default.
• W2578256220 hasConcept C555293320 @default.
• W2578256220 hasConcept C71924100 @default.
• W2578256220 hasConcept C86803240 @default.
• W2578256220 hasConcept C99454951 @default.
• W2578256220 hasConceptScore W2578256220C126322002 @default.
• W2578256220 hasConceptScore W2578256220C134018914 @default.
• W2578256220 hasConceptScore W2578256220C138816342 @default.
• W2578256220 hasConceptScore W2578256220C142462285 @default.
• W2578256220 hasConceptScore W2578256220C142724271 @default.
• W2578256220 hasConceptScore W2578256220C151730666 @default.
• W2578256220 hasConceptScore W2578256220C159110408 @default.
• W2578256220 hasConceptScore W2578256220C177713679 @default.
• W2578256220 hasConceptScore W2578256220C197934379 @default.

• next