FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2578448302> ?p ?o ?g. }

• W2578448302 abstract "Abstract Adenosine is a neuromodulator present in various areas of the central nervous system, including the retina. Adenosine may serve a neuroprotective role in the retina, based on electroretinogram (ERG) recordings from the rat retina. Our purpose was to assess the role of A 2A and A 3 adenosine receptors in the generation and modulation of the rat ERG. The flash ERG was recorded with corneal electrodes from Sprague Dawley rats. Agonists and antagonists for A 2A and A 3 receptors, and adenosine were injected (5 µ l) into the vitreous. The effects on the components of the single flash scotopic and photopic ERGs were examined, and ERG flicker. Adenosine (0.5 mM) increased the mean amplitudes of the scotopic ERG a-waves (68 ± 8 to 97 ± 14 µ V, P = 0.042), and b-waves (236 ± 38 µ V to 305 ± 42 µ V). A 2A agonist CGS21680 (2 mM) reduced the mean amplitude of the ERG b-wave, from 298 ± 21 µ V in response to the brightest stimulus to 212 ± 19 µ V ( P = 0.005), and mean scotopic oscillatory potentials (OPs) from 100 ± 9 µ V to 47 ± 11 µ V ( P = 0.023). ZM241385 [4 mM], an A 2A antagonist, decreased the scotopic b-wave of the ERG. A 3 agonist 2-CI-IB-MECA (0.5 mM) increased the a-wave, while decreasing the scotopic and photopic ERG b-waves, and the scotopic OPs. A 3 antagonist VUF5574 (1 mM) increased the mean amplitude of the scotopic a-wave (66 ± 8 to 140 ± 29 µ V, P = 0.046) and b-wave (224 ± 20 to 312 ± 39 µ V, P = 0.0037). No significant effects on ERG flicker were found. We conclude that retinal neurons containing A 2A and/or A 3 adenosine receptors contribute to the generation of the ERG a- and b-waves and OPs." @default.
• W2578448302 created "2017-01-26" @default.
• W2578448302 creator A5021729671 @default.
• W2578448302 creator A5074810336 @default.
• W2578448302 date "2017-01-01" @default.
• W2578448302 modified "2023-09-26" @default.
• W2578448302 title "Retinal A_2A and A₃ adenosine receptors modulate the components of the rat electroretinogram" @default.
• W2578448302 cites W1147134861 @default.
• W2578448302 cites W1409773207 @default.
• W2578448302 cites W148894833 @default.
• W2578448302 cites W1529567719 @default.
• W2578448302 cites W1538913626 @default.
• W2578448302 cites W1542711346 @default.
• W2578448302 cites W1929256833 @default.
• W2578448302 cites W1970767863 @default.
• W2578448302 cites W1971505749 @default.
• W2578448302 cites W1972133451 @default.
• W2578448302 cites W1972393828 @default.
• W2578448302 cites W1973820324 @default.
• W2578448302 cites W1974984557 @default.
• W2578448302 cites W1981502205 @default.
• W2578448302 cites W1981735532 @default.
• W2578448302 cites W1984258648 @default.
• W2578448302 cites W1985598247 @default.
• W2578448302 cites W1985822845 @default.
• W2578448302 cites W1992292431 @default.
• W2578448302 cites W1993761825 @default.
• W2578448302 cites W1995810932 @default.
• W2578448302 cites W2019388498 @default.
• W2578448302 cites W2020186276 @default.
• W2578448302 cites W2022307075 @default.
• W2578448302 cites W2023448141 @default.
• W2578448302 cites W2031817173 @default.
• W2578448302 cites W2035107045 @default.
• W2578448302 cites W2037180653 @default.
• W2578448302 cites W2039655309 @default.
• W2578448302 cites W2041989809 @default.
• W2578448302 cites W2042263119 @default.
• W2578448302 cites W2042354542 @default.
• W2578448302 cites W2043127603 @default.
• W2578448302 cites W2043899109 @default.
• W2578448302 cites W2050163330 @default.
• W2578448302 cites W2051518486 @default.
• W2578448302 cites W2055354826 @default.
• W2578448302 cites W2061473590 @default.
• W2578448302 cites W2073324143 @default.
• W2578448302 cites W2077355368 @default.
• W2578448302 cites W2082248168 @default.
• W2578448302 cites W2086633705 @default.
• W2578448302 cites W2087342049 @default.
• W2578448302 cites W2089404402 @default.
• W2578448302 cites W2093777829 @default.
• W2578448302 cites W2117254234 @default.
• W2578448302 cites W2121315957 @default.
• W2578448302 cites W2127471192 @default.
• W2578448302 cites W2127983733 @default.
• W2578448302 cites W2134271696 @default.
• W2578448302 cites W2135002291 @default.
• W2578448302 cites W2137536138 @default.
• W2578448302 cites W2137772461 @default.
• W2578448302 cites W2145758516 @default.
• W2578448302 cites W2163306024 @default.
• W2578448302 cites W2169920833 @default.
• W2578448302 cites W2183769824 @default.
• W2578448302 cites W2255944078 @default.
• W2578448302 cites W2329913331 @default.
• W2578448302 cites W2416719835 @default.
• W2578448302 doi "https://doi.org/10.1017/s0952523816000171" @default.
• W2578448302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28304243" @default.
• W2578448302 hasPublicationYear "2017" @default.
• W2578448302 type Work @default.
• W2578448302 sameAs 2578448302 @default.
• W2578448302 citedByCount "5" @default.
• W2578448302 countsByYear W25784483022019 @default.
• W2578448302 countsByYear W25784483022020 @default.
• W2578448302 countsByYear W25784483022022 @default.
• W2578448302 crossrefType "journal-article" @default.
• W2578448302 hasAuthorship W2578448302A5021729671 @default.
• W2578448302 hasAuthorship W2578448302A5074810336 @default.
• W2578448302 hasConcept C103796816 @default.
• W2578448302 hasConcept C118487528 @default.
• W2578448302 hasConcept C12554922 @default.
• W2578448302 hasConcept C126322002 @default.
• W2578448302 hasConcept C134018914 @default.
• W2578448302 hasConcept C169760540 @default.
• W2578448302 hasConcept C170493617 @default.
• W2578448302 hasConcept C185592680 @default.
• W2578448302 hasConcept C2776991684 @default.
• W2578448302 hasConcept C2777093970 @default.
• W2578448302 hasConcept C2778938600 @default.
• W2578448302 hasConcept C2779113765 @default.
• W2578448302 hasConcept C54497739 @default.
• W2578448302 hasConcept C67907053 @default.
• W2578448302 hasConcept C71924100 @default.
• W2578448302 hasConcept C7243750 @default.
• W2578448302 hasConcept C86803240 @default.
• W2578448302 hasConceptScore W2578448302C103796816 @default.
• W2578448302 hasConceptScore W2578448302C118487528 @default.
• W2578448302 hasConceptScore W2578448302C12554922 @default.
• W2578448302 hasConceptScore W2578448302C126322002 @default.

• next