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- W2578581861 abstract "The effects of oxygen on the excitability of neurons have been studied in various groups of animals (Chalazonitis and Sugaya, 1958; Eccles et aI, 1966; Chalazonitis, 1968; Kerkut and York, 1969; Steefin, 1975). However, the difficulty in recording intracellular P02 (I·P02) has prevented gathering of essential information concerning the effects of I·P02 on oxidative processes and on the bioelectric phenomena of neurons. Since many giant neurons in the Aplysia abdominal ganglion are easily identifiable, stable for several days and can be penetrated with newly improved P02 microelectrodes f we have employed them in a study of neuronal oxygen sensitivity. Chalazonitis has shown the effects of oxygen on the properties of the neuronal membrane in Aplysia by recording simultaneously, their bioelectrical properties and their I·P02 by spectrophotometry. In the present study, we have confirmed his results of hypoxic effects on change in membrane potential and spontaneous activity. In addition, our observations reveal oxygen profiles in Aplysia neurons by recording extracellular P02 (E·P02) and I·P02 from very small points at various depths in the cell. This allows us to correlate more closely the local oxygen level, metabolic processes and active pump with the bioelectric activities of the neurons." @default.
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- W2578581861 date "1978-01-01" @default.
- W2578581861 modified "2023-09-27" @default.
- W2578581861 title "THE SENSITIVITY OF APLYSIA GIANT NEURONS TO CHANGES" @default.
- W2578581861 hasPublicationYear "1978" @default.
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