FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2578627739> ?p ?o ?g. }

• W2578627739 endingPage "e1006576" @default.
• W2578627739 startingPage "e1006576" @default.
• W2578627739 abstract "Manipulation of sex determination pathways in insects provides the basis for a wide spectrum of strategies to benefit agriculture and public health. Furthermore, insects display a remarkable diversity in the genetic pathways that lead to sex differentiation. The silkworm, Bombyx mori, has been cultivated by humans as a beneficial insect for over two millennia, and more recently as a model system for studying lepidopteran genetics and development. Previous studies have identified the B. mori Fem piRNA as the primary female determining factor and BmMasc as its downstream target, while the genetic scenario for male sex determination was still unclear. In the current study, we exploite the transgenic CRISPR/Cas9 system to generate a comprehensive set of knockout mutations in genes BmSxl, Bmtra2, BmImp, BmImpM, BmPSI and BmMasc, to investigate their roles in silkworm sex determination. Absence of Bmtra2 results in the complete depletion of Bmdsx transcripts, which is the conserved downstream factor in the sex determination pathway, and induces embryonic lethality. Loss of BmImp or BmImpM function does not affect the sexual differentiation. Mutations in BmPSI and BmMasc genes affect the splicing of Bmdsx and the female reproductive apparatus appeared in the male external genital. Intriguingly, we identify that BmPSI regulates expression of BmMasc, BmImpM and Bmdsx, supporting the conclusion that it acts as a key auxiliary factor in silkworm male sex determination." @default.
• W2578627739 created "2017-01-26" @default.
• W2578627739 creator A5027347639 @default.
• W2578627739 creator A5032522966 @default.
• W2578627739 creator A5039756363 @default.
• W2578627739 creator A5057040354 @default.
• W2578627739 creator A5071244967 @default.
• W2578627739 creator A5084845938 @default.
• W2578627739 date "2017-01-19" @default.
• W2578627739 modified "2023-10-15" @default.
• W2578627739 title "Bombyx mori P-element Somatic Inhibitor (BmPSI) Is a Key Auxiliary Factor for Silkworm Male Sex Determination" @default.
• W2578627739 cites W1919573053 @default.
• W2578627739 cites W1965538482 @default.
• W2578627739 cites W1967059376 @default.
• W2578627739 cites W1976445111 @default.
• W2578627739 cites W1976855656 @default.
• W2578627739 cites W1980689984 @default.
• W2578627739 cites W1980864858 @default.
• W2578627739 cites W1984509766 @default.
• W2578627739 cites W1989624726 @default.
• W2578627739 cites W1990022233 @default.
• W2578627739 cites W1993234921 @default.
• W2578627739 cites W1996245162 @default.
• W2578627739 cites W1999265573 @default.
• W2578627739 cites W2000479887 @default.
• W2578627739 cites W2004730785 @default.
• W2578627739 cites W2004798712 @default.
• W2578627739 cites W2009208217 @default.
• W2578627739 cites W2013146348 @default.
• W2578627739 cites W2018628396 @default.
• W2578627739 cites W2023207021 @default.
• W2578627739 cites W2027596441 @default.
• W2578627739 cites W2028285308 @default.
• W2578627739 cites W2029789055 @default.
• W2578627739 cites W2031320371 @default.
• W2578627739 cites W2040557482 @default.
• W2578627739 cites W2056931196 @default.
• W2578627739 cites W2061374646 @default.
• W2578627739 cites W2063113536 @default.
• W2578627739 cites W2063530272 @default.
• W2578627739 cites W2073004311 @default.
• W2578627739 cites W2076241630 @default.
• W2578627739 cites W2081667081 @default.
• W2578627739 cites W2085421027 @default.
• W2578627739 cites W2090632804 @default.
• W2578627739 cites W2092058408 @default.
• W2578627739 cites W2100309727 @default.
• W2578627739 cites W2101943001 @default.
• W2578627739 cites W2104905785 @default.
• W2578627739 cites W2110447200 @default.
• W2578627739 cites W2113962028 @default.
• W2578627739 cites W2121214853 @default.
• W2578627739 cites W2130847592 @default.
• W2578627739 cites W2133616621 @default.
• W2578627739 cites W2136065795 @default.
• W2578627739 cites W2136294994 @default.
• W2578627739 cites W2140282079 @default.
• W2578627739 cites W2144411350 @default.
• W2578627739 cites W2145782793 @default.
• W2578627739 cites W2154417257 @default.
• W2578627739 cites W2155896486 @default.
• W2578627739 cites W2160345222 @default.
• W2578627739 cites W2163963918 @default.
• W2578627739 cites W2169874591 @default.
• W2578627739 cites W2388274197 @default.
• W2578627739 cites W2557205411 @default.
• W2578627739 doi "https://doi.org/10.1371/journal.pgen.1006576" @default.
• W2578627739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5289617" @default.
• W2578627739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28103247" @default.
• W2578627739 hasPublicationYear "2017" @default.
• W2578627739 type Work @default.
• W2578627739 sameAs 2578627739 @default.
• W2578627739 citedByCount "81" @default.
• W2578627739 countsByYear W25786277392017 @default.
• W2578627739 countsByYear W25786277392018 @default.
• W2578627739 countsByYear W25786277392019 @default.
• W2578627739 countsByYear W25786277392020 @default.
• W2578627739 countsByYear W25786277392021 @default.
• W2578627739 countsByYear W25786277392022 @default.
• W2578627739 countsByYear W25786277392023 @default.
• W2578627739 crossrefType "journal-article" @default.
• W2578627739 hasAuthorship W2578627739A5027347639 @default.
• W2578627739 hasAuthorship W2578627739A5032522966 @default.
• W2578627739 hasAuthorship W2578627739A5039756363 @default.
• W2578627739 hasAuthorship W2578627739A5057040354 @default.
• W2578627739 hasAuthorship W2578627739A5071244967 @default.
• W2578627739 hasAuthorship W2578627739A5084845938 @default.
• W2578627739 hasBestOaLocation W25786277391 @default.
• W2578627739 hasConcept C102230213 @default.
• W2578627739 hasConcept C104317684 @default.
• W2578627739 hasConcept C134305767 @default.
• W2578627739 hasConcept C2778487026 @default.
• W2578627739 hasConcept C54355233 @default.
• W2578627739 hasConcept C63405245 @default.
• W2578627739 hasConcept C86803240 @default.
• W2578627739 hasConcept C98108389 @default.
• W2578627739 hasConceptScore W2578627739C102230213 @default.
• W2578627739 hasConceptScore W2578627739C104317684 @default.

• next