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• W257863171 abstract "According to the classical theory of radiation genetics, the dose-response curve for the one-hit aberrations is linear and independent of the intensity or dose rate of radiation. In the case of two-hit aberrations, the frequency of aberrations increased as the square of the dose. Newcombe (1942) postulated that a break in a chromosome may restitute in a given period of time. The phenomena of chromosomal restitution or the existing of a rejoining system was further confirmed by Wolff (1956) others. If restitution in the first break occurs before the formation of a second break, chromosomal aberration of the rearrangment type is no longer possible. Therefore with decreased dose-rate the frequencies of the two-hit aberrations will be decreased. Few reports on the intensity effect of radiation on mammalian chromosomes in culture have been published so far. Brewen (1963) working with chromosomes of the Chinese hamster, found that in contrary to the classical theory, the intensity effect was existing in the one-hit aberrations as well as in the two-hit aberrations. The dose rate effect was explained by the differential effect on the rejoining systems. Bell Baker (1962) only found intensity effect with the two-hit aberration but not with the one-hit aberrations in the chromosomes of human leucocyte culture.Human blood was freshly drawn and irradiated in vitro with X-rays. The dose rate used was 3r, 31r and 202r per minute. The range of doses irradiated was 30r-240r. A therapeutic machine was used at 180kv, 15 ma with a 3mm Al filter. Leucocytes were seperated immediatly after irradiation and cultured according to Mo-orhead with some modifications. Method of aberration scoring was the same as described in author's previous paper (Wang, 1964). The results of covariance analysis of our data show that there are statistically significant differences between the frequencies of chromosome aberrations induced by two different dose rates, 31r mm 202r/min. for both the one-hit and two-hit aberrations. Our experimental results support the findings of Brewen (1963). Therefore we propose that the classical theory of radiation genetics is subjected to some partial modification, i.e., intensity effect exists in one-hit as well as in two-hit chromosome aberrations. Further investigations arc required to clarify the machanisms of intensity effect in the one-hit aberrations. Regression curves were drawn for one-hit and two-hit chromosome aberrations on the X-ray doses at different dose rate levels (fig. 1, 2). Dose-square relationship was found to be significant at the high dose rate of 202r per minute, both for two-hit and one-hit aberrations. Possible explanations were made for the non-linear dose-response of the one-hit aberrations epecially at high dose-rate." @default.
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• W257863171 date "1966-01-01" @default.
• W257863171 modified "2023-09-28" @default.
• W257863171 title "THE EFFECT OF RADIATION DOSE RATE ON THE FREQUENCY OF CHROMOSOME ABERRATIONS INDUCED IN HUMAN LEUCOCYTES IRRADIATED IN VITRO" @default.
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