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- W2578647673 abstract "Background We aimed to evaluate the efficacy of a new combination antiemetic therapy comprising aprepitant, granisetron, and dexamethasone in gastric cancer patients undergoing chemotherapy with cisplatin and S-1. Methods Gastric cancer patients scheduled to receive their first course of chemotherapy with cisplatin (60 mg/m 2 ) and S-1 (80 mg/m 2 ) were treated with a new combination antiemetic therapy aprepitant, granisetron, and dexamethasone on day 1; aprepitant and dexamethasone on days 2 and 3; and dexamethasone on day 4. The patients reported vomiting, nausea, use of rescue therapy, and change in the amount of diet intake, and completed the Functional Living Index-Emesis (FLIE) questionnaire. The primary endpoint was complete response (CR; no emesis and use of no rescue antiemetics) during the overall study phase (0–120 h after cisplatin administration). The secondary endpoints included complete protection (CP; CR plus no significant nausea); change in the amount of diet intake; and the impact of chemotherapy-induced nausea and vomiting (CINV) on daily life during the overall, acute (0–24 h), and delayed (24–120 h) phases. Results Fifty-three patients were included. CR was achieved in 88.7, 98.1, and 88.7 % of patients in the overall, acute, and delayed phases, respectively. The corresponding rates of CP were 67.9, 96.2, and 67.9 %." @default.
- W2578647673 created "2017-01-26" @default.
- W2578647673 creator A5011681054 @default.
- W2578647673 date "2013-01-01" @default.
- W2578647673 modified "2023-09-27" @default.
- W2578647673 title "Aprepitant plus granisetron and dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients with gastric cancer treated with S-1 plus cisplatin Katsunobu OyamaSachio FushidaMasahide KajiToshiya TakedaShinichi KinamiYasuo Hirono • Katsuhiro YoshimotoKazuhisa YabushitaHisashi HirosawaYuki TakaiTatsuo Nakano • Hironobu KimuraToshiaki YasuiAtsushi TsunedaTomoya TsukadaJun KinoshitaTakashi Fujimura •" @default.
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