FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2578752802> ?p ?o ?g. }

• W2578752802 endingPage "11" @default.
• W2578752802 startingPage "11" @default.
• W2578752802 abstract "One of the truly remarkable discoveries in modern biology is the finding that the nervous, endocrine, and immune systems use a common chemical language for intra- and inter-system communication. Specifically, the endocrine and immune systems produce a common set of molecules that act on a common repertoire of receptors in the 2 systems. Here, I will also review more recent studies that have delineated hardwired and humoral pathways for such bidirectional communication. This is discussed in the context of the idea that the sharing of ligands and receptors allows the immune system to serve as the sixth sense that notifies the endocrine system of the presence of entities, such as viruses and bacteria, that are imperceptible to the classic senses. Based on this, attempts are made to explain the increasing strong evidence that high yielding dairy cows are extremely susceptible to infectious diseases and that this has severe economic consequences for the dairy industry and welfare implications. Preliminary functional evidence will be presented showing that the innate immune response differs among cow breeds and that these differences are potentially linked to selective pressure on the endocrine system in the widest sense (meaning selection for higher production), which resulted in a potential appropriate “loss of function” with respect to immune parameters. It will be shown that the ability of macrophages (MØ) to kill pathogens using oxygen-dependent and independent mechanisms differ among cow breeds. The oxygen-dependent mechanisms rely on the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS production has been shown to activate the inflammasome complex in MØ, leading to increased production of the pro-inflammatory cytokine Interleukin-1β (IL-1β). Conversely, RNS inhibits inflammasome mediated IL-1β activation, indicating a division between inflammasome activation and RNS production. These differences are linked to the ability of cows to deal with invading pathogens. Collectively, these preliminary data suggest that the dichotomy of inflammasome activation and RNS production exists in cattle and differs between these 2 breeds. As pattern recognition receptors and signaling pathways are involved in the assessed functional differences presented herein, the data potentially aid the identification of in vitro predictors of appropriate innate immune response. Finally, these predictors may assist in discovering candidate genes conferring increased disease resistance for future use in combination with known production traits." @default.
• W2578752802 created "2017-01-26" @default.
• W2578752802 creator A5061861242 @default.
• W2578752802 date "2016-09-01" @default.
• W2578752802 modified "2023-09-24" @default.
• W2578752802 title "S0121 Are we loosing our sixth sense?" @default.
• W2578752802 doi "https://doi.org/10.2527/jas2016.94supplement411x" @default.
• W2578752802 hasPublicationYear "2016" @default.
• W2578752802 type Work @default.
• W2578752802 sameAs 2578752802 @default.
• W2578752802 citedByCount "0" @default.
• W2578752802 crossrefType "journal-article" @default.
• W2578752802 hasAuthorship W2578752802A5061861242 @default.
• W2578752802 hasConcept C121332964 @default.
• W2578752802 hasConcept C134018914 @default.
• W2578752802 hasConcept C136449434 @default.
• W2578752802 hasConcept C14036430 @default.
• W2578752802 hasConcept C151730666 @default.
• W2578752802 hasConcept C169760540 @default.
• W2578752802 hasConcept C170493617 @default.
• W2578752802 hasConcept C203014093 @default.
• W2578752802 hasConcept C24890656 @default.
• W2578752802 hasConcept C2778473898 @default.
• W2578752802 hasConcept C2779343474 @default.
• W2578752802 hasConcept C46699223 @default.
• W2578752802 hasConcept C54355233 @default.
• W2578752802 hasConcept C71315377 @default.
• W2578752802 hasConcept C78458016 @default.
• W2578752802 hasConcept C86803240 @default.
• W2578752802 hasConcept C8891405 @default.
• W2578752802 hasConceptScore W2578752802C121332964 @default.
• W2578752802 hasConceptScore W2578752802C134018914 @default.
• W2578752802 hasConceptScore W2578752802C136449434 @default.
• W2578752802 hasConceptScore W2578752802C14036430 @default.
• W2578752802 hasConceptScore W2578752802C151730666 @default.
• W2578752802 hasConceptScore W2578752802C169760540 @default.
• W2578752802 hasConceptScore W2578752802C170493617 @default.
• W2578752802 hasConceptScore W2578752802C203014093 @default.
• W2578752802 hasConceptScore W2578752802C24890656 @default.
• W2578752802 hasConceptScore W2578752802C2778473898 @default.
• W2578752802 hasConceptScore W2578752802C2779343474 @default.
• W2578752802 hasConceptScore W2578752802C46699223 @default.
• W2578752802 hasConceptScore W2578752802C54355233 @default.
• W2578752802 hasConceptScore W2578752802C71315377 @default.
• W2578752802 hasConceptScore W2578752802C78458016 @default.
• W2578752802 hasConceptScore W2578752802C86803240 @default.
• W2578752802 hasConceptScore W2578752802C8891405 @default.
• W2578752802 hasIssue "suppl_4" @default.
• W2578752802 hasLocation W25787528021 @default.
• W2578752802 hasOpenAccess W2578752802 @default.
• W2578752802 hasPrimaryLocation W25787528021 @default.
• W2578752802 hasRelatedWork W1524155111 @default.
• W2578752802 hasRelatedWork W1556307916 @default.
• W2578752802 hasRelatedWork W1980618878 @default.
• W2578752802 hasRelatedWork W2008306603 @default.
• W2578752802 hasRelatedWork W2084905130 @default.
• W2578752802 hasRelatedWork W2103515427 @default.
• W2578752802 hasRelatedWork W2141330728 @default.
• W2578752802 hasRelatedWork W261021342 @default.
• W2578752802 hasRelatedWork W2946615038 @default.
• W2578752802 hasRelatedWork W1991503912 @default.
• W2578752802 hasVolume "94" @default.
• W2578752802 isParatext "false" @default.
• W2578752802 isRetracted "false" @default.
• W2578752802 magId "2578752802" @default.
• W2578752802 workType "article" @default.