FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2578808164> ?p ?o ?g. }

• W2578808164 endingPage "742" @default.
• W2578808164 startingPage "734" @default.
• W2578808164 abstract "Purpose Early-stage hepatocellular carcinoma (E-HCC) is being diagnosed increasingly, and in one half of diagnosed patients, recurrence will develop. Thus, it is urgent to identify recurrence-related markers. We investigated the effectiveness of CpG methylation in predicting recurrence for patients with E-HCCs. Patients and Methods In total, 576 patients with E-HCC from four independent centers were sorted by three phases. In the discovery phase, 66 tumor samples were analyzed using the Illumina Methylation 450k Beadchip. Two algorithms, Least Absolute Shrinkage and Selector Operation and Support Vector Machine-Recursive Feature Elimination, were used to select significant CpGs. In the training phase, penalized Cox regression was used to further narrow CpGs into 140 samples. In the validation phase, candidate CpGs were validated using an internal cohort (n = 141) and two external cohorts (n = 191 and n =104). Results After combining the 46 CpGs selected by the Least Absolute Shrinkage and Selector Operation and the Support Vector Machine-Recursive Feature Elimination algorithms, three CpGs corresponding to SCAN domain containing 3, Src homology 3-domain growth factor receptor-bound 2-like interacting protein 1, and peptidase inhibitor 3 were highlighted as candidate predictors in the training phase. On the basis of the three CpGs, a methylation signature for E-HCC (MSEH) was developed to classify patients into high- and low-risk recurrence groups in the training cohort ( P < .001). The performance of MSEH was validated in the internal cohort ( P < .001) and in the two external cohorts ( P < .001; P = .002). Furthermore, a nomogram comprising MSEH, tumor differentiation, cirrhosis, hepatitis B virus surface antigen, and antivirus therapy was generated to predict the 5-year recurrence-free survival in the training cohort, and it performed well in the three validation cohorts (concordance index: 0.725, 0.697, and 0.693, respectively). Conclusion MSEH, a three-CpG–based signature, is useful in predicting recurrence for patients with E-HCC." @default.
• W2578808164 created "2017-01-26" @default.
• W2578808164 creator A5005839192 @default.
• W2578808164 creator A5016674513 @default.
• W2578808164 creator A5029266541 @default.
• W2578808164 creator A5043687065 @default.
• W2578808164 creator A5046183867 @default.
• W2578808164 creator A5046963739 @default.
• W2578808164 creator A5047968001 @default.
• W2578808164 creator A5054499936 @default.
• W2578808164 creator A5067483347 @default.
• W2578808164 creator A5070705784 @default.
• W2578808164 creator A5075846774 @default.
• W2578808164 creator A5080366436 @default.
• W2578808164 creator A5081641076 @default.
• W2578808164 creator A5083111185 @default.
• W2578808164 creator A5088408355 @default.
• W2578808164 creator A5089748838 @default.
• W2578808164 creator A5090243481 @default.
• W2578808164 date "2017-03-01" @default.
• W2578808164 modified "2023-10-18" @default.
• W2578808164 title "CpG Methylation Signature Predicts Recurrence in Early-Stage Hepatocellular Carcinoma: Results From a Multicenter Study" @default.
• W2578808164 cites W1019795062 @default.
• W2578808164 cites W1776292783 @default.
• W2578808164 cites W1819353054 @default.
• W2578808164 cites W1929386821 @default.
• W2578808164 cites W1964368260 @default.
• W2578808164 cites W1973413549 @default.
• W2578808164 cites W1977736328 @default.
• W2578808164 cites W2002906231 @default.
• W2578808164 cites W2003825154 @default.
• W2578808164 cites W2015939473 @default.
• W2578808164 cites W2021481801 @default.
• W2578808164 cites W2031842191 @default.
• W2578808164 cites W2043235003 @default.
• W2578808164 cites W2052491055 @default.
• W2578808164 cites W2063407515 @default.
• W2578808164 cites W2082809341 @default.
• W2578808164 cites W2086454839 @default.
• W2578808164 cites W2087825235 @default.
• W2578808164 cites W2090596338 @default.
• W2578808164 cites W2096045149 @default.
• W2578808164 cites W2100545040 @default.
• W2578808164 cites W2105824687 @default.
• W2578808164 cites W2114633835 @default.
• W2578808164 cites W2125900063 @default.
• W2578808164 cites W2126929024 @default.
• W2578808164 cites W2127431419 @default.
• W2578808164 cites W2127821100 @default.
• W2578808164 cites W2131105131 @default.
• W2578808164 cites W2149199519 @default.
• W2578808164 cites W2151080109 @default.
• W2578808164 cites W2158324181 @default.
• W2578808164 cites W2163945848 @default.
• W2578808164 cites W2324757592 @default.
• W2578808164 cites W2333367339 @default.
• W2578808164 doi "https://doi.org/10.1200/jco.2016.68.2153" @default.
• W2578808164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28068175" @default.
• W2578808164 hasPublicationYear "2017" @default.
• W2578808164 type Work @default.
• W2578808164 sameAs 2578808164 @default.
• W2578808164 citedByCount "112" @default.
• W2578808164 countsByYear W25788081642017 @default.
• W2578808164 countsByYear W25788081642018 @default.
• W2578808164 countsByYear W25788081642019 @default.
• W2578808164 countsByYear W25788081642020 @default.
• W2578808164 countsByYear W25788081642021 @default.
• W2578808164 countsByYear W25788081642022 @default.
• W2578808164 countsByYear W25788081642023 @default.
• W2578808164 crossrefType "journal-article" @default.
• W2578808164 hasAuthorship W2578808164A5005839192 @default.
• W2578808164 hasAuthorship W2578808164A5016674513 @default.
• W2578808164 hasAuthorship W2578808164A5029266541 @default.
• W2578808164 hasAuthorship W2578808164A5043687065 @default.
• W2578808164 hasAuthorship W2578808164A5046183867 @default.
• W2578808164 hasAuthorship W2578808164A5046963739 @default.
• W2578808164 hasAuthorship W2578808164A5047968001 @default.
• W2578808164 hasAuthorship W2578808164A5054499936 @default.
• W2578808164 hasAuthorship W2578808164A5067483347 @default.
• W2578808164 hasAuthorship W2578808164A5070705784 @default.
• W2578808164 hasAuthorship W2578808164A5075846774 @default.
• W2578808164 hasAuthorship W2578808164A5080366436 @default.
• W2578808164 hasAuthorship W2578808164A5081641076 @default.
• W2578808164 hasAuthorship W2578808164A5083111185 @default.
• W2578808164 hasAuthorship W2578808164A5088408355 @default.
• W2578808164 hasAuthorship W2578808164A5089748838 @default.
• W2578808164 hasAuthorship W2578808164A5090243481 @default.
• W2578808164 hasConcept C104317684 @default.
• W2578808164 hasConcept C11413529 @default.
• W2578808164 hasConcept C126322002 @default.
• W2578808164 hasConcept C140173407 @default.
• W2578808164 hasConcept C143998085 @default.
• W2578808164 hasConcept C146357865 @default.
• W2578808164 hasConcept C150194340 @default.
• W2578808164 hasConcept C151730666 @default.
• W2578808164 hasConcept C190727270 @default.
• W2578808164 hasConcept C2778019345 @default.
• W2578808164 hasConcept C2779314089 @default.

• next