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- W2578890449 abstract "Cyclic diadenosine monophosphate (c-di-AMP) is a conserved nucleotide second messenger critical for bacterial growth and resistance to cell wall-active antibiotics. In Listeria monocytogenes, the sole diadenylate cyclase, DacA, is essential in rich, but not synthetic media and ΔdacA mutants are highly sensitive to the β-lactam antibiotic cefuroxime. In this study, loss of function mutations in the oligopeptide importer (oppABCDF) and glycine betaine importer (gbuABC) allowed ΔdacA mutants to grow in rich medium. Since oligopeptides were sufficient to inhibit growth of the ΔdacA mutant we hypothesized that oligopeptides act as osmolytes, similar to glycine betaine, to disrupt intracellular osmotic pressure. Supplementation with salt stabilized the ΔdacA mutant in rich medium and restored cefuroxime resistance. Additional suppressor mutations in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefuroxime resistance and resulted in a 100-fold increase in virulence of the ΔdacA mutant. PycA is inhibited by c-di-AMP and these mutations prompted us to examine the role of TCA cycle enzymes. Inactivation of citrate synthase, but not down-stream enzymes suppressed ΔdacA phenotypes. These data suggested that c-di-AMP modulates central metabolism at the pyruvate node to moderate citrate production and indeed, the ΔdacA mutant accumulated six times the concentration of citrate present in wild-type bacteria." @default.
- W2578890449 created "2017-01-26" @default.
- W2578890449 creator A5004904484 @default.
- W2578890449 creator A5012504037 @default.
- W2578890449 creator A5034420582 @default.
- W2578890449 creator A5052742681 @default.
- W2578890449 creator A5060050107 @default.
- W2578890449 creator A5065758883 @default.
- W2578890449 creator A5079455535 @default.
- W2578890449 date "2017-03-08" @default.
- W2578890449 modified "2023-10-18" @default.
- W2578890449 title "<scp>c</scp> ‐di‐ <scp>AMP</scp> modulates <scp> <i>L</i> </scp> <i>isteria monocytogenes</i> central metabolism to regulate growth, antibiotic resistance and osmoregulation" @default.
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