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- W2578922016 abstract "It is well known that exposure of sensitive cells to receptor agonists can cause a progressive reduction in their capacity to respond to this and related agonists. This phenomenon has been observed with cells expressing receptors from different superfamilies, and has been termed desensitization, refractoriness, tolerance, or tachyphylaxis [I}. The mechanisms responsible for this phenomenon have been studied extensively in cells that synthesize cyclic AMP in response to beta-adrenergic agonists. Exposure of such cells to isoproterenol or similar drugs may result in receptor uncoupling, receptor sequestration, and ultimately, in downregulation of receptors, resulting in a decline in the actual number of receptors [2}. Much less is known about receptors that inhibit adenylyl cyclase activity such as opiate, alpha2 adrenergic, or certain types of muscarinic receptors, but desensitization of those receptors after prolonged exposure to agonist has been described in many cases [l}. Several groups have investigated the mechanisms involved in the desensitization of the Al adenosine receptor as another member of the family of inhibitory receptors. In analogy to other G-proteincoupled receptors, there is evidence that Al adenosine receptors might also undergo desensitization after prolonged or repeated incubation with agonist. Desensitization of A 1 Adenosine Receptor-Mediated Inhibition of Adenylyl Cyclase Activity" @default.
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- W2578922016 date "1995-01-01" @default.
- W2578922016 modified "2023-09-24" @default.
- W2578922016 title "16. DESENSITIZATION OF Al ADENOSINE RECEPTORS" @default.
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