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- W2578984598 abstract "Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes were associated with developmental alterations in oxytocinergic (OXT) neurons. Thus, otpa and otpb differentially regulate neuropeptide switching in a newly identified subset of OXT neurons that co-express the corticotropin-releasing hormone (CRH). Single-cell analysis revealed that these neurons project mostly to the hindbrain and spinal cord. Ablation of this neuronal subset specifically reduced adult social preference without affecting stress behavior, thereby uncoupling the contribution of a specific OXT cluster to social behavior from the general otpa−/− deficits. Our findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete OXT circuit whose disrupted development affects social behavior." @default.
- W2578984598 created "2017-01-26" @default.
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- W2578984598 date "2017-01-17" @default.
- W2578984598 modified "2023-10-13" @default.
- W2578984598 title "Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior" @default.
- W2578984598 cites W1033049088 @default.
- W2578984598 cites W1509046486 @default.
- W2578984598 cites W1550463592 @default.
- W2578984598 cites W1560037133 @default.
- W2578984598 cites W1560069809 @default.
- W2578984598 cites W156107071 @default.
- W2578984598 cites W1647810205 @default.
- W2578984598 cites W1786725698 @default.
- W2578984598 cites W1920899731 @default.
- W2578984598 cites W1924375074 @default.
- W2578984598 cites W1963831028 @default.
- W2578984598 cites W1965138369 @default.
- W2578984598 cites W1970231625 @default.
- W2578984598 cites W1974370090 @default.
- W2578984598 cites W1977780909 @default.
- W2578984598 cites W1989062378 @default.
- W2578984598 cites W1996218087 @default.
- W2578984598 cites W1999077862 @default.
- W2578984598 cites W1999603779 @default.
- W2578984598 cites W2000075940 @default.
- W2578984598 cites W2000948792 @default.
- W2578984598 cites W2001340933 @default.
- W2578984598 cites W2001486453 @default.
- W2578984598 cites W2003590296 @default.
- W2578984598 cites W2005074550 @default.
- W2578984598 cites W2005631411 @default.
- W2578984598 cites W2011445819 @default.
- W2578984598 cites W2014115747 @default.
- W2578984598 cites W2014548509 @default.
- W2578984598 cites W2017931574 @default.
- W2578984598 cites W2018078680 @default.
- W2578984598 cites W2020738467 @default.
- W2578984598 cites W2023261615 @default.
- W2578984598 cites W2026580449 @default.
- W2578984598 cites W2027676008 @default.
- W2578984598 cites W2032967567 @default.
- W2578984598 cites W2034342718 @default.
- W2578984598 cites W2043507006 @default.
- W2578984598 cites W2046504195 @default.
- W2578984598 cites W2049586893 @default.
- W2578984598 cites W2049807398 @default.
- W2578984598 cites W2055593778 @default.
- W2578984598 cites W2057462189 @default.
- W2578984598 cites W2059882495 @default.
- W2578984598 cites W2063580069 @default.
- W2578984598 cites W2065636600 @default.
- W2578984598 cites W2069290560 @default.
- W2578984598 cites W2072080093 @default.
- W2578984598 cites W2078832578 @default.
- W2578984598 cites W2078944460 @default.
- W2578984598 cites W2079821310 @default.
- W2578984598 cites W2080004698 @default.
- W2578984598 cites W2083607629 @default.
- W2578984598 cites W2094107463 @default.
- W2578984598 cites W2099168883 @default.
- W2578984598 cites W2105232945 @default.
- W2578984598 cites W2106505481 @default.
- W2578984598 cites W2112726670 @default.
- W2578984598 cites W2116040831 @default.
- W2578984598 cites W2131330949 @default.
- W2578984598 cites W2137368211 @default.
- W2578984598 cites W2144813261 @default.
- W2578984598 cites W2145936102 @default.
- W2578984598 cites W2162953149 @default.
- W2578984598 cites W2162954233 @default.
- W2578984598 cites W2163237124 @default.
- W2578984598 cites W2165266294 @default.
- W2578984598 cites W2167789289 @default.
- W2578984598 cites W2216755319 @default.
- W2578984598 cites W2252899440 @default.
- W2578984598 cites W2292055541 @default.
- W2578984598 cites W2411337851 @default.
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- W2578984598 cites W2498537245 @default.
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- W2578984598 doi "https://doi.org/10.7554/elife.22170" @default.
- W2578984598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5293488" @default.
- W2578984598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28094761" @default.
- W2578984598 hasPublicationYear "2017" @default.
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