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- W2579040260 abstract "The mechanism of neurodegeneration caused by -amyloid inAlzheimer disease is controversial. Neuronal toxicity is exertedmostlybyvariousspeciesofsoluble -amyloidoligomersthatdifferintheirN-andC-terminaldomains.However,abundantaccumula-tion of -amyloid also occurs in the brains of cognitively normalelderlypeople,intheabsenceofobviousneuronaldysfunction.Wepostulatedthatneuronaltoxicitydependsonthemolecularcompo-sition,ratherthantheamount,ofthesoluble -amyloidoligomers.Hereweshowthatsoluble -amyloidaggregatesthataccumulateinAlzheimer disease are different from those of normal aging inregard to the composition as well as the aggregation and toxicityproperties.Aseriesofevidenceindicatesthatprogressivecerebralaccumulationof -amyloid (A )," @default.
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- W2579040260 date "2005-01-01" @default.
- W2579040260 modified "2023-09-24" @default.
- W2579040260 title "Amyloid Is Different in Normal Aging and in" @default.
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