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• W2579218703 abstract "Abstract Gene expression is influenced by extrinsic noise (involving a fluctuating environment of cellular processes) and intrinsic noise (referring to fluctuations within a cell under constant environment). We study the standard model of gene expression including an (in-)active gene, mRNA and protein. Gene expression is regulated in the sense that the protein feeds back and either represses (negative feedback) or enhances (positive feedback) its production at the stage of transcription. While it is well-known that negative (positive) feedback reduces (increases) intrinsic noise, we give a precise result on the resulting fluctuations in protein numbers. The technique we use is an extension of the Langevin approximation and is an application of a central limit theorem under stochastic averaging for Markov jump processes (Kang, Kurtz and Popovic, 2014). We find that (under our scaling and in equilibrium), negative feedback leads to a reduction in the Fano factor of at most 2, while the noise under positive feedback is potentially unbounded. The fit with simulations is very good and improves on known approximations." @default.
• W2579218703 created "2017-01-26" @default.
• W2579218703 creator A5040455184 @default.
• W2579218703 creator A5091710048 @default.
• W2579218703 date "2017-01-12" @default.
• W2579218703 modified "2023-09-24" @default.
• W2579218703 title "Limits of noise for autoregulated gene expression" @default.
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• W2579218703 doi "https://doi.org/10.1101/100115" @default.
• W2579218703 hasPublicationYear "2017" @default.
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