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- W2579227727 abstract "BACKGROUND The bicompartmental model with gamma-distributed absorption times is a useful empirical model for drugs whose absorption kinetics is not zeroor first-order. We derived for this model a steady-state equation, involving one parameter less than the previous derivation (1). The equation involves the incomplete gamma function P. An approximation (based on equivalence with a chi-squared distribution) is proposed in order to facilitate its implementation in NONMEM. OBJECTIVES To compare the population estimates obtained with NONMEM (approximate equation for P) and MONOLIX (no approximation for P) on real data. RESULTS AND DISCUSSION" @default.
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- W2579227727 date "2007-01-01" @default.
- W2579227727 modified "2023-09-24" @default.
- W2579227727 title "Steady-state Equation for the Bicompartmental Model with Gamma Absorption. Application to Mycophenolate PK in Renal Transplant Patients" @default.
- W2579227727 cites W2170120409 @default.
- W2579227727 hasPublicationYear "2007" @default.
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