Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579394996> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2579394996 abstract "Abstract Tubulin Polymerization Promoting Protein (TPPP/p25) is a brain-specific disordered protein that modulates the dynamics and stability of the microtubule network by its assembly promoting, cross-linking and acetylation enhancing activities. In normal brain it is expressed primarily in differentiated oligodendrocytes; however, at pathological conditions it is enriched in inclusions of both neurons and oligodendrocytes characteristic for Parkinson’s disease and multiple system atrophy, respectively. The objective of this paper is to highlight a critical point of a recently published Skoufias’s paper in which the crucial role of the microtubules in TPPP/p25 dimerization leading to microtubule bundling was suggested. However, our previous and present data provide evidence for the microtubule-independent dimerization of TPPP/p25 and its stabilization by disulphide bridges. In addition, our bimolecular fluorescence complementation experiments revealed the dimerization ability of both the full length and the terminal-free (CORE) TPPP/p25 forms, however, while TPPP/p25 aligned along the bundled microtubule network, the associated CORE segments distributed mostly homogeneously within the cytosol. Now, we identified a molecular model from the possible ones suggested in the Skoufias’s paper that could be responsible for stabilization of the microtubule network in the course of the oligodendrocyte differentiation, consequently in the constitution of the myelin sheath." @default.
- W2579394996 created "2017-01-26" @default.
- W2579394996 creator A5000859100 @default.
- W2579394996 creator A5023912155 @default.
- W2579394996 creator A5058146124 @default.
- W2579394996 creator A5078455552 @default.
- W2579394996 creator A5089811106 @default.
- W2579394996 creator A5090070043 @default.
- W2579394996 date "2017-01-11" @default.
- W2579394996 modified "2023-10-18" @default.
- W2579394996 title "Further evidence for microtubule-independent dimerization of TPPP/p25" @default.
- W2579394996 cites W1870626249 @default.
- W2579394996 cites W1992830187 @default.
- W2579394996 cites W1995669448 @default.
- W2579394996 cites W2009419515 @default.
- W2579394996 cites W2014177596 @default.
- W2579394996 cites W2015752112 @default.
- W2579394996 cites W2018523851 @default.
- W2579394996 cites W2019110823 @default.
- W2579394996 cites W2020261376 @default.
- W2579394996 cites W2024188968 @default.
- W2579394996 cites W2026794889 @default.
- W2579394996 cites W2048403302 @default.
- W2579394996 cites W2050265691 @default.
- W2579394996 cites W2053187409 @default.
- W2579394996 cites W2057732851 @default.
- W2579394996 cites W2085013728 @default.
- W2579394996 cites W2086746882 @default.
- W2579394996 cites W2088786068 @default.
- W2579394996 cites W2091456854 @default.
- W2579394996 cites W2112703333 @default.
- W2579394996 cites W2113188581 @default.
- W2579394996 cites W2133991836 @default.
- W2579394996 doi "https://doi.org/10.1038/srep40594" @default.
- W2579394996 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5225419" @default.
- W2579394996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28074911" @default.
- W2579394996 hasPublicationYear "2017" @default.
- W2579394996 type Work @default.
- W2579394996 sameAs 2579394996 @default.
- W2579394996 citedByCount "11" @default.
- W2579394996 countsByYear W25793949962017 @default.
- W2579394996 countsByYear W25793949962018 @default.
- W2579394996 countsByYear W25793949962019 @default.
- W2579394996 countsByYear W25793949962020 @default.
- W2579394996 countsByYear W25793949962021 @default.
- W2579394996 countsByYear W25793949962022 @default.
- W2579394996 countsByYear W25793949962023 @default.
- W2579394996 crossrefType "journal-article" @default.
- W2579394996 hasAuthorship W2579394996A5000859100 @default.
- W2579394996 hasAuthorship W2579394996A5023912155 @default.
- W2579394996 hasAuthorship W2579394996A5058146124 @default.
- W2579394996 hasAuthorship W2579394996A5078455552 @default.
- W2579394996 hasAuthorship W2579394996A5089811106 @default.
- W2579394996 hasAuthorship W2579394996A5090070043 @default.
- W2579394996 hasBestOaLocation W25793949961 @default.
- W2579394996 hasConcept C104317684 @default.
- W2579394996 hasConcept C119157956 @default.
- W2579394996 hasConcept C12554922 @default.
- W2579394996 hasConcept C181199279 @default.
- W2579394996 hasConcept C185592680 @default.
- W2579394996 hasConcept C190062978 @default.
- W2579394996 hasConcept C20418707 @default.
- W2579394996 hasConcept C55493867 @default.
- W2579394996 hasConcept C86803240 @default.
- W2579394996 hasConcept C95444343 @default.
- W2579394996 hasConcept C98539663 @default.
- W2579394996 hasConceptScore W2579394996C104317684 @default.
- W2579394996 hasConceptScore W2579394996C119157956 @default.
- W2579394996 hasConceptScore W2579394996C12554922 @default.
- W2579394996 hasConceptScore W2579394996C181199279 @default.
- W2579394996 hasConceptScore W2579394996C185592680 @default.
- W2579394996 hasConceptScore W2579394996C190062978 @default.
- W2579394996 hasConceptScore W2579394996C20418707 @default.
- W2579394996 hasConceptScore W2579394996C55493867 @default.
- W2579394996 hasConceptScore W2579394996C86803240 @default.
- W2579394996 hasConceptScore W2579394996C95444343 @default.
- W2579394996 hasConceptScore W2579394996C98539663 @default.
- W2579394996 hasIssue "1" @default.
- W2579394996 hasLocation W25793949961 @default.
- W2579394996 hasLocation W25793949962 @default.
- W2579394996 hasLocation W25793949963 @default.
- W2579394996 hasLocation W25793949964 @default.
- W2579394996 hasOpenAccess W2579394996 @default.
- W2579394996 hasPrimaryLocation W25793949961 @default.
- W2579394996 hasRelatedWork W1534984749 @default.
- W2579394996 hasRelatedWork W1990523844 @default.
- W2579394996 hasRelatedWork W2062058625 @default.
- W2579394996 hasRelatedWork W2147200212 @default.
- W2579394996 hasRelatedWork W2473805125 @default.
- W2579394996 hasRelatedWork W2909456234 @default.
- W2579394996 hasRelatedWork W2949380999 @default.
- W2579394996 hasRelatedWork W3036214510 @default.
- W2579394996 hasRelatedWork W4206409668 @default.
- W2579394996 hasRelatedWork W948219868 @default.
- W2579394996 hasVolume "7" @default.
- W2579394996 isParatext "false" @default.
- W2579394996 isRetracted "false" @default.
- W2579394996 magId "2579394996" @default.
- W2579394996 workType "article" @default.