Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579423189> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2579423189 abstract "Abstract The direct thrombin inhibitors lepirudin and argatroban are widely used to treat heparin induced thrombocytopenia (HIT). It has been suggested that the Ecarin™ (Echis carinatus venom) clotting time may be superior to the activated partial thromboplastin time (APTT) for monioring purposes. We have prepared standard curves for lepirudin (Refludan™) and Argatroban covering therapeutic drug levels and corresponding APTT ratios (clotting time/control clotting time). Ecarin™ clotting time ratios were performed to demonstrate the practical application of these curves in the clinical care of patients. We report the case of an 80 year old man with HIT/HITT syndrome that occurred during therapy for deep vein thrombosis (DVT) with a low molecular weight heparin (LMWH). His initial coagulation studies were abnormal due to warfarin and LMWH therapy. The patient had a moderate impairment of renal function. Lepirudin therapy in a bolus dose of 14 mg (patient weight: 103.0 kg) resulted in supratherapeutic blood levels of drug and hematuria (Platelet count: 〉200 x 103). Dosage adjustment to maintain an APTT ratio of 1.5 for five days caused no hematuria, but thromboembolic complications occurred at that ratio. The in-vitro dose response curve for Lepirudin was compared with the Ecarin™ clotting time (ECT) ratio at those same concentration ranges in the same plasma. For comparison, Argatroban dose response curves in-vitro were made as well. ECT ratios were very similar to the APTT ratios in the patient’s samples. Representative ratios after the initial bolus, during the infusion period of five days and at the termination of that period are shown in the following table: Comparison of APTT and ECT Ratios APTT Ratio ECT Ratio 1.43 1.07 3.98 3.08 2.91 1.95 2.74 1.95 2.79 1.90 2.58 1.78 2.44 2.42 3.83 4.78 Conclusion: The ECT ratios reflect a steeper dose response curve than that observed with the APTT ratios. This may permit more accurate measurement of blood levels using ECT ratios." @default.
- W2579423189 created "2017-01-26" @default.
- W2579423189 creator A5003781122 @default.
- W2579423189 creator A5012966149 @default.
- W2579423189 creator A5036786065 @default.
- W2579423189 creator A5051205420 @default.
- W2579423189 creator A5078589039 @default.
- W2579423189 creator A5085109332 @default.
- W2579423189 date "2005-11-16" @default.
- W2579423189 modified "2023-09-28" @default.
- W2579423189 title "Comparison of Activated Partial Thromboplastin Time Ratios with Ecarin Clotting Time Ratios for Monitoring Direct Thrombin Inhibitor Therapy: In-Vitro Study and Case Study of Lepirudin Therapy." @default.
- W2579423189 doi "https://doi.org/10.1182/blood.v106.11.4149.4149" @default.
- W2579423189 hasPublicationYear "2005" @default.
- W2579423189 type Work @default.
- W2579423189 sameAs 2579423189 @default.
- W2579423189 citedByCount "0" @default.
- W2579423189 crossrefType "journal-article" @default.
- W2579423189 hasAuthorship W2579423189A5003781122 @default.
- W2579423189 hasAuthorship W2579423189A5012966149 @default.
- W2579423189 hasAuthorship W2579423189A5036786065 @default.
- W2579423189 hasAuthorship W2579423189A5051205420 @default.
- W2579423189 hasAuthorship W2579423189A5078589039 @default.
- W2579423189 hasAuthorship W2579423189A5085109332 @default.
- W2579423189 hasConcept C126322002 @default.
- W2579423189 hasConcept C141071460 @default.
- W2579423189 hasConcept C2777292125 @default.
- W2579423189 hasConcept C2777987278 @default.
- W2579423189 hasConcept C2778205648 @default.
- W2579423189 hasConcept C2778261982 @default.
- W2579423189 hasConcept C2779612170 @default.
- W2579423189 hasConcept C2780077467 @default.
- W2579423189 hasConcept C2780205058 @default.
- W2579423189 hasConcept C42219234 @default.
- W2579423189 hasConcept C43376680 @default.
- W2579423189 hasConcept C57002609 @default.
- W2579423189 hasConcept C71924100 @default.
- W2579423189 hasConcept C77171857 @default.
- W2579423189 hasConcept C89560881 @default.
- W2579423189 hasConcept C98274493 @default.
- W2579423189 hasConceptScore W2579423189C126322002 @default.
- W2579423189 hasConceptScore W2579423189C141071460 @default.
- W2579423189 hasConceptScore W2579423189C2777292125 @default.
- W2579423189 hasConceptScore W2579423189C2777987278 @default.
- W2579423189 hasConceptScore W2579423189C2778205648 @default.
- W2579423189 hasConceptScore W2579423189C2778261982 @default.
- W2579423189 hasConceptScore W2579423189C2779612170 @default.
- W2579423189 hasConceptScore W2579423189C2780077467 @default.
- W2579423189 hasConceptScore W2579423189C2780205058 @default.
- W2579423189 hasConceptScore W2579423189C42219234 @default.
- W2579423189 hasConceptScore W2579423189C43376680 @default.
- W2579423189 hasConceptScore W2579423189C57002609 @default.
- W2579423189 hasConceptScore W2579423189C71924100 @default.
- W2579423189 hasConceptScore W2579423189C77171857 @default.
- W2579423189 hasConceptScore W2579423189C89560881 @default.
- W2579423189 hasConceptScore W2579423189C98274493 @default.
- W2579423189 hasLocation W25794231891 @default.
- W2579423189 hasOpenAccess W2579423189 @default.
- W2579423189 hasPrimaryLocation W25794231891 @default.
- W2579423189 hasRelatedWork W2001904766 @default.
- W2579423189 hasRelatedWork W2041259818 @default.
- W2579423189 hasRelatedWork W2101979147 @default.
- W2579423189 hasRelatedWork W2157100114 @default.
- W2579423189 hasRelatedWork W2170703129 @default.
- W2579423189 hasRelatedWork W2571344505 @default.
- W2579423189 hasRelatedWork W2576161055 @default.
- W2579423189 hasRelatedWork W2579423189 @default.
- W2579423189 hasRelatedWork W2597781848 @default.
- W2579423189 hasRelatedWork W2793474595 @default.
- W2579423189 isParatext "false" @default.
- W2579423189 isRetracted "false" @default.
- W2579423189 magId "2579423189" @default.
- W2579423189 workType "article" @default.