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- W2579423286 abstract "Abstract Background: In this ethnopharmacological study, methanolic extract of the aerial plant parts of Methods: The cold methanolic extract of the aerial plant parts of Results: In the mice model, the MEPK, PEFMEPK, and CTFMEPK fractions showed significant peripheral analgesic activity at a dose of 400 mg/kg body weight with percentage of inhibition of acetic acid-induced writhing 77.67 (p<0.001), 33.50 (p<0.001), and 40.29 (p<0.001), respectively, compared to the standard dichlofenac (60.68%, p<0.001) group. The hypoglycemic properties of MEPK, PEFMEPK, and CTFMEPK extracts were evaluated in normoglycemic mice where the reduction of blood glucose level after 30 min of glucose load were 69.85%, 78.91%, and 72.73%, respectively, and for standard glibenclamide, the reduction was 72.85%. All results were significant (p<0.05). In the case of the CNS depressant activity by phenobarbitone-induced sleeping time test, the crude ME significantly reduced sleep latency by 57.14% and increased the duration of sleep by 63.29% compared to the control, which were comparable to that of standard diazepam (65.71% and 77.62%, respectively). Among all the extract and fractions, methanolic extract showed the maximum antidiarrheal effect. The methanolic extract at 200 mg/kg dose induced a significant decrease in the total number of defecation in 4 h (69.05% of inhibition, p<0.001) and at 400 mg/kg dose showed 76.19% of inhibition (p<0.001). Conclusions: In light of the available literature, these findings represent the first experimental investigation of biological activities of" @default.
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- W2579423286 date "2017-01-01" @default.
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- W2579423286 title "Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)" @default.
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- W2579423286 doi "https://doi.org/10.1515/jbcpp-2016-0066" @default.
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