FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579543144> ?p ?o ?g. }

• W2579543144 endingPage "462" @default.
• W2579543144 startingPage "453" @default.
• W2579543144 abstract "Insomnia is comorbid with internalizing and externalizing psychiatric disorders. However, the extent to which the etiologic influences on insomnia and common psychopathology overlap is unclear. There are limited genetically informed studies of insomnia and internalizing disorders and few studies of overlap exist with externalizing disorders.We utilized twin data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders (total n = 7,500). Insomnia, internalizing disorders (major depressive disorder [MDD], generalized anxiety disorder [GAD]), and alcohol abuse or dependence (AAD) were assessed at two time points, while antisocial personality disorder (ASPD) was assessed once. Cholesky decompositions were performed in OpenMx and longitudinal measurement models were run on available phenotypes to reduce measurement error.The latent additive genetic influences on insomnia overlapped significantly (56% for females, 74% for males) with MDD and were shared completely (100%) with GAD. There was significant overlap of latent unique environmental influences, with overlap ranging from 38 to 100% across disorders. In contrast, there was less genetic overlap between insomnia and externalizing disorders, with 18% of insomnia's heritability shared with AAD and 23% with ASPD. Latent unique environmental overlap between insomnia and both externalizing disorders was negligible.The evidence for substantial genetic overlap between insomnia and stable aspects of both internalizing disorders suggests that there may be few insomnia-specific genes and investigation into unique environmental factors is important for understanding insomnia development. The modest overlap between insomnia and externalizing disorders indicates that these disorders are genetically related, but largely etiologically distinct." @default.
• W2579543144 created "2017-01-26" @default.
• W2579543144 creator A5011961838 @default.
• W2579543144 creator A5017432551 @default.
• W2579543144 creator A5026191415 @default.
• W2579543144 creator A5033126709 @default.
• W2579543144 creator A5042386498 @default.
• W2579543144 creator A5056448263 @default.
• W2579543144 creator A5073155296 @default.
• W2579543144 date "2017-01-16" @default.
• W2579543144 modified "2023-10-17" @default.
• W2579543144 title "An examination of the etiologic overlap between the genetic and environmental influences on insomnia and common psychopathology" @default.
• W2579543144 cites W1555810878 @default.
• W2579543144 cites W1561568624 @default.
• W2579543144 cites W1627352250 @default.
• W2579543144 cites W1840838328 @default.
• W2579543144 cites W1992146265 @default.
• W2579543144 cites W1995228249 @default.
• W2579543144 cites W2009845727 @default.
• W2579543144 cites W2014880231 @default.
• W2579543144 cites W2018590161 @default.
• W2579543144 cites W2021668262 @default.
• W2579543144 cites W2023144714 @default.
• W2579543144 cites W2047673113 @default.
• W2579543144 cites W2059206004 @default.
• W2579543144 cites W2060606855 @default.
• W2579543144 cites W2065692954 @default.
• W2579543144 cites W2081686158 @default.
• W2579543144 cites W2084462194 @default.
• W2579543144 cites W2094616210 @default.
• W2579543144 cites W2098405376 @default.
• W2579543144 cites W2111632215 @default.
• W2579543144 cites W2112641910 @default.
• W2579543144 cites W2115412209 @default.
• W2579543144 cites W2122704094 @default.
• W2579543144 cites W2131794873 @default.
• W2579543144 cites W2135302959 @default.
• W2579543144 cites W2136100428 @default.
• W2579543144 cites W2143511454 @default.
• W2579543144 cites W2154058918 @default.
• W2579543144 cites W2171161022 @default.
• W2579543144 cites W2227188615 @default.
• W2579543144 cites W2438110065 @default.
• W2579543144 cites W39816332 @default.
• W2579543144 cites W4237377395 @default.
• W2579543144 cites W4247665917 @default.
• W2579543144 cites W2041913737 @default.
• W2579543144 doi "https://doi.org/10.1002/da.22587" @default.
• W2579543144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5469037" @default.
• W2579543144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28092418" @default.
• W2579543144 hasPublicationYear "2017" @default.
• W2579543144 type Work @default.
• W2579543144 sameAs 2579543144 @default.
• W2579543144 citedByCount "38" @default.
• W2579543144 countsByYear W25795431442016 @default.
• W2579543144 countsByYear W25795431442018 @default.
• W2579543144 countsByYear W25795431442019 @default.
• W2579543144 countsByYear W25795431442020 @default.
• W2579543144 countsByYear W25795431442021 @default.
• W2579543144 countsByYear W25795431442022 @default.
• W2579543144 countsByYear W25795431442023 @default.
• W2579543144 crossrefType "journal-article" @default.
• W2579543144 hasAuthorship W2579543144A5011961838 @default.
• W2579543144 hasAuthorship W2579543144A5017432551 @default.
• W2579543144 hasAuthorship W2579543144A5026191415 @default.
• W2579543144 hasAuthorship W2579543144A5033126709 @default.
• W2579543144 hasAuthorship W2579543144A5042386498 @default.
• W2579543144 hasAuthorship W2579543144A5056448263 @default.
• W2579543144 hasAuthorship W2579543144A5073155296 @default.
• W2579543144 hasBestOaLocation W25795431441 @default.
• W2579543144 hasConcept C118552586 @default.
• W2579543144 hasConcept C123273963 @default.
• W2579543144 hasConcept C15744967 @default.
• W2579543144 hasConcept C161890455 @default.
• W2579543144 hasConcept C169594400 @default.
• W2579543144 hasConcept C169900460 @default.
• W2579543144 hasConcept C190385971 @default.
• W2579543144 hasConcept C2776276179 @default.
• W2579543144 hasConcept C2779911313 @default.
• W2579543144 hasConcept C2780051608 @default.
• W2579543144 hasConcept C2780135496 @default.
• W2579543144 hasConcept C2781210498 @default.
• W2579543144 hasConcept C3017944768 @default.
• W2579543144 hasConcept C54355233 @default.
• W2579543144 hasConcept C558461103 @default.
• W2579543144 hasConcept C70410870 @default.
• W2579543144 hasConcept C71924100 @default.
• W2579543144 hasConcept C86803240 @default.
• W2579543144 hasConcept C99454951 @default.
• W2579543144 hasConceptScore W2579543144C118552586 @default.
• W2579543144 hasConceptScore W2579543144C123273963 @default.
• W2579543144 hasConceptScore W2579543144C15744967 @default.
• W2579543144 hasConceptScore W2579543144C161890455 @default.
• W2579543144 hasConceptScore W2579543144C169594400 @default.
• W2579543144 hasConceptScore W2579543144C169900460 @default.
• W2579543144 hasConceptScore W2579543144C190385971 @default.
• W2579543144 hasConceptScore W2579543144C2776276179 @default.
• W2579543144 hasConceptScore W2579543144C2779911313 @default.

• next