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- W2579562287 abstract "The signals causing the resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute.We analysed the expression of ptx3 after muscle injury and verified whether hematopoietic precursors are a source of the protein. The kinetics of regeneration and leukocytes infiltration, the accumulation of cell remnants and anti-histidyl-t-RNA synthetase autoantibodies were compared in wild-type and ptx3-deficient mice.Ptx3 expression was up-regulated three-five days after injury and restricted to the extracellular matrix. Cellular debris and leukocytes persisted in the muscle of ptx3-deficient mice for a long time after wild-type animals had healed. ptx3-deficient macrophages expressed receptors involved in apoptotic cell clearance and engulfed dead cells in vitro. Accumulation of cell debris in a pro-inflammatory microenvironment was not sufficient to elicit autoantibodies.PTX3 generated in response to muscle injury prompts the clearance of debris and the termination of the inflammatory response." @default.
- W2579562287 created "2017-01-26" @default.
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- W2579562287 date "2016-01-01" @default.
- W2579562287 modified "2023-10-14" @default.
- W2579562287 title "Clearance of Cell Remnants and Regeneration of Injured Muscle Depend on Soluble Pattern Recognition Receptor PTX3" @default.
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- W2579562287 doi "https://doi.org/10.2119/molmed.2016.00002" @default.
- W2579562287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5263058" @default.
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