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- W2579620121 abstract "Increased production of nitric oxide (NO) by iNOS (inducible nitric oxide synthase) and PGE2 (prostaglandin E2) by COX-2 (Cyclooxygenase -2) are the key molecular events that occur during the inflammatory process. Previous studies have shown that NO influence the expression of COX-2 in a different manner in different cells. We studied the mechanism by which NO regulates the expression of COX-2 in LPS stimulated murine macrophage cell line RAW264.7. Treatment of the cells with NOS inhibitor L-Nω-Nitroarginine (L-NNA) in the presence of LPS (1μg/ml) reduced the production of NO in cultured macrophages. Moreover, significant inhibition of COX-2 was observed when the cells were treated with L-NNA (8.1μM) for 18 h in the presence of LPS. Reporter gene analysis and mRNA analysis by RT-PCR showed that NO also regulates COX-2 expression at transcription level. Additional experiments suggested that L-NNA mediated inhibition of COX-2 is due to blocking of NF-κB, ERK, C-Jun, AKT as well as proinflammatory cytokines like TNF-α and IL-1β." @default.
- W2579620121 created "2017-01-26" @default.
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- W2579620121 date "2016-01-01" @default.
- W2579620121 modified "2023-09-23" @default.
- W2579620121 title "L-Nω-Nitroarginine Inhibits the Induction of Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2) by Inhibiting NF-κB and AP-1 Activation in RAW 264.7 Cells" @default.
- W2579620121 doi "https://doi.org/10.4172/2169-0138.1000135" @default.
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