FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579817813> ?p ?o ?g. }

• W2579817813 endingPage "616" @default.
• W2579817813 startingPage "606" @default.
• W2579817813 abstract "Non-alcoholic steatohepatitis (NASH) affects 8-10 million people in the US and up to 75% of obese individuals. Despite this, there are no approved oral therapeutics to treat NASH and therefore the need for novel approaches exists. The estrogen receptor β (ER-β)-selective agonist, β-LGND2, inhibits body weight and white adipose tissue, and increases metabolism, resulting in higher energy expenditure and thermogenesis. Due to favorable effects of β-LGND2 on obesity, we hypothesized that β-LGND2 will prevent NASH directly by reducing lipid accumulation in the liver or indirectly by favorably changing body composition. Male C57BL/6 mice fed with high fat diet (HFD) for 10 weeks or methionine choline-deficient diet for four weeks and treated with vehicle exhibited altered liver weights by twofold and increased serum transaminases by 2-6-folds. These changes were not observed in β-LGND2-treated animals. Infiltration of inflammatory cells and collagen deposits, an indication of fibrosis, were observed in the liver of mice fed with HFD for 10 weeks, which were effectively blocked by β-LGND2. Gene expression studies in the liver indicate that pregnane X receptor target genes were significantly increased by HFD, and the increase was inhibited by β-LGND2. On the other hand, metabolomics indicate that bile acid metabolites were significantly increased by β-LGND2. These studies demonstrate that an ER-β agonist might provide therapeutic benefits in NASH by directly modulating the function of xenobiotic and bile acid receptors in the liver, which have important functions in the liver, and indirectly, as demonstrated before, by inhibiting adiposity. Impact statement Over 75-90% of those classified as clinically obese suffer from co-morbidities, the most common of which is non-alcoholic steatohepatitis (NASH). While there are currently no effective treatment approaches for NASH, data presented here provide preliminary evidence that an estrogen receptor β-selective ligand could have the potential to reduce lipid accumulation and inflammation, and protect liver from NASH." @default.
• W2579817813 created "2017-01-26" @default.
• W2579817813 creator A5010625614 @default.
• W2579817813 creator A5016676195 @default.
• W2579817813 creator A5047077102 @default.
• W2579817813 creator A5052790109 @default.
• W2579817813 creator A5058014595 @default.
• W2579817813 creator A5067659573 @default.
• W2579817813 date "2017-01-16" @default.
• W2579817813 modified "2023-09-22" @default.
• W2579817813 title "An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors" @default.
• W2579817813 cites W1225575464 @default.
• W2579817813 cites W1622799587 @default.
• W2579817813 cites W1834481809 @default.
• W2579817813 cites W1937678125 @default.
• W2579817813 cites W1951641979 @default.
• W2579817813 cites W1965079305 @default.
• W2579817813 cites W1969807612 @default.
• W2579817813 cites W1975808053 @default.
• W2579817813 cites W1976621716 @default.
• W2579817813 cites W1977036235 @default.
• W2579817813 cites W1980270094 @default.
• W2579817813 cites W1984821297 @default.
• W2579817813 cites W2015429374 @default.
• W2579817813 cites W2015711200 @default.
• W2579817813 cites W2017173759 @default.
• W2579817813 cites W2031469397 @default.
• W2579817813 cites W2039019782 @default.
• W2579817813 cites W2044603199 @default.
• W2579817813 cites W2052725031 @default.
• W2579817813 cites W2053581007 @default.
• W2579817813 cites W2067740038 @default.
• W2579817813 cites W2070391921 @default.
• W2579817813 cites W2071489706 @default.
• W2579817813 cites W2081999578 @default.
• W2579817813 cites W2085766690 @default.
• W2579817813 cites W2089264179 @default.
• W2579817813 cites W2123106337 @default.
• W2579817813 cites W2123609879 @default.
• W2579817813 cites W2130410032 @default.
• W2579817813 cites W2131372305 @default.
• W2579817813 cites W2131609948 @default.
• W2579817813 cites W2134778167 @default.
• W2579817813 cites W2137506791 @default.
• W2579817813 cites W2142789398 @default.
• W2579817813 cites W2142844314 @default.
• W2579817813 cites W2148878254 @default.
• W2579817813 cites W2162502779 @default.
• W2579817813 cites W2164961630 @default.
• W2579817813 cites W2167556679 @default.
• W2579817813 cites W2264072217 @default.
• W2579817813 cites W2278837089 @default.
• W2579817813 cites W2299651948 @default.
• W2579817813 cites W2338267111 @default.
• W2579817813 cites W2401145004 @default.
• W2579817813 cites W2421775421 @default.
• W2579817813 cites W2428513306 @default.
• W2579817813 cites W2483891712 @default.
• W2579817813 cites W2523163592 @default.
• W2579817813 cites W2530492717 @default.
• W2579817813 doi "https://doi.org/10.1177/1535370216688569" @default.
• W2579817813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5685260" @default.
• W2579817813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28092182" @default.
• W2579817813 hasPublicationYear "2017" @default.
• W2579817813 type Work @default.
• W2579817813 sameAs 2579817813 @default.
• W2579817813 citedByCount "16" @default.
• W2579817813 countsByYear W25798178132019 @default.
• W2579817813 countsByYear W25798178132020 @default.
• W2579817813 countsByYear W25798178132021 @default.
• W2579817813 countsByYear W25798178132022 @default.
• W2579817813 crossrefType "journal-article" @default.
• W2579817813 hasAuthorship W2579817813A5010625614 @default.
• W2579817813 hasAuthorship W2579817813A5016676195 @default.
• W2579817813 hasAuthorship W2579817813A5047077102 @default.
• W2579817813 hasAuthorship W2579817813A5052790109 @default.
• W2579817813 hasAuthorship W2579817813A5058014595 @default.
• W2579817813 hasAuthorship W2579817813A5067659573 @default.
• W2579817813 hasBestOaLocation W25798178132 @default.
• W2579817813 hasConcept C104317684 @default.
• W2579817813 hasConcept C121608353 @default.
• W2579817813 hasConcept C126322002 @default.
• W2579817813 hasConcept C132040763 @default.
• W2579817813 hasConcept C134018914 @default.
• W2579817813 hasConcept C151279926 @default.
• W2579817813 hasConcept C151955695 @default.
• W2579817813 hasConcept C170493617 @default.
• W2579817813 hasConcept C171089720 @default.
• W2579817813 hasConcept C185592680 @default.
• W2579817813 hasConcept C2778163477 @default.
• W2579817813 hasConcept C2778772119 @default.
• W2579817813 hasConcept C2778938600 @default.
• W2579817813 hasConcept C2779134260 @default.
• W2579817813 hasConcept C2779478299 @default.
• W2579817813 hasConcept C530470458 @default.
• W2579817813 hasConcept C55493867 @default.
• W2579817813 hasConcept C63932345 @default.
• W2579817813 hasConcept C71924100 @default.

• next