FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579871959> ?p ?o ?g. }

• W2579871959 endingPage "e000314" @default.
• W2579871959 startingPage "e000314" @default.
• W2579871959 abstract "<h3>Objective</h3> To compare the risk of lupus-like events (LLEs) and vasculitis-like events (VLEs) in tumour necrosis factor-α inhibitor (TNFi)-treated patients with rheumatoid arthritis (RA) to those receiving non-biological disease-modifying antirheumatic drugs (nbDMARDs). <h3>Methods</h3> Patients were recruited to the British Society for Rheumatology Biologics Register—RA, a national prospective cohort study. Two cohorts recruited between 2001 and 2015: (1) patients starting first TNFi (adalimumab, etanercept, infliximab and certolizumab) (n=12 937) and (2) biological-naïve comparison cohort receiving nbDMARDs (n=3673). The risk of an event was compared between the two cohorts using Cox proportional-hazard models, adjusted using propensity scores. Rates of LLE/VLE were compared between TNFi and nbDMARD patients. <h3>Results</h3> The crude incidence rates for LLEs were: TNFi 10/10 000 patient-years (pyrs) (95% CI 8 to 13) and nbDMARD 2/10 000 pyrs (95% CI 1 to 6); for VLEs: TNFi 15/10 000 pyrs (95% CI 12 to 19) and nbDMARD 7/10 000 pyrs (95% CI 4 to 12). The risk of both events was highest in the first year of TNFi treatment. After adjusting for differences in baseline characteristics, there was no difference in risk of LLEs (_adjHR 1.86; 95% CI 0.52 to 6.58) or VLEs (_adjHR 1.27; 95% CI 0.40 to 4.04) for TNFi compared to nbDMARD-treated patients. Infliximab conferred the highest overall risk, followed by etanercept, although 95% CIs overlapped following adjustment. <h3>Conclusions</h3> In one of the largest biological registers, the absolute risk of both events is low. The addition of TNFi to nbDMARD does not alter the risk of either event in patients with RA selected for TNFi. This is the first study to assess the risk of these outcomes in a prospective, observational cohort." @default.
• W2579871959 created "2017-01-26" @default.
• W2579871959 creator A5025085488 @default.
• W2579871959 creator A5027951754 @default.
• W2579871959 creator A5033406574 @default.
• W2579871959 creator A5036981821 @default.
• W2579871959 creator A5041920873 @default.
• W2579871959 creator A5047692275 @default.
• W2579871959 creator A5047807604 @default.
• W2579871959 creator A5054757083 @default.
• W2579871959 creator A5065779609 @default.
• W2579871959 creator A5075860605 @default.
• W2579871959 creator A5090230000 @default.
• W2579871959 date "2017-01-01" @default.
• W2579871959 modified "2023-10-14" @default.
• W2579871959 title "Drug-specific risk and characteristics of lupus and vasculitis-like events in patients with rheumatoid arthritis treated with TNFi: results from BSRBR-RA" @default.
• W2579871959 cites W1518420099 @default.
• W2579871959 cites W1579633379 @default.
• W2579871959 cites W1588728586 @default.
• W2579871959 cites W1955559925 @default.
• W2579871959 cites W1980012705 @default.
• W2579871959 cites W1985763670 @default.
• W2579871959 cites W1987893275 @default.
• W2579871959 cites W1997610571 @default.
• W2579871959 cites W2024363295 @default.
• W2579871959 cites W2029993898 @default.
• W2579871959 cites W2042585904 @default.
• W2579871959 cites W2070527591 @default.
• W2579871959 cites W2096545621 @default.
• W2579871959 cites W2100435187 @default.
• W2579871959 cites W2107590323 @default.
• W2579871959 cites W2111999104 @default.
• W2579871959 cites W2141633191 @default.
• W2579871959 cites W2147751728 @default.
• W2579871959 cites W2149065814 @default.
• W2579871959 cites W2149521567 @default.
• W2579871959 cites W2152973730 @default.
• W2579871959 cites W2153153909 @default.
• W2579871959 cites W2159860161 @default.
• W2579871959 cites W2162716725 @default.
• W2579871959 cites W2168781986 @default.
• W2579871959 cites W2410306672 @default.
• W2579871959 cites W4239255024 @default.
• W2579871959 doi "https://doi.org/10.1136/rmdopen-2016-000314" @default.
• W2579871959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5255894" @default.
• W2579871959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28123776" @default.
• W2579871959 hasPublicationYear "2017" @default.
• W2579871959 type Work @default.
• W2579871959 sameAs 2579871959 @default.
• W2579871959 citedByCount "25" @default.
• W2579871959 countsByYear W25798719592017 @default.
• W2579871959 countsByYear W25798719592018 @default.
• W2579871959 countsByYear W25798719592019 @default.
• W2579871959 countsByYear W25798719592020 @default.
• W2579871959 countsByYear W25798719592021 @default.
• W2579871959 countsByYear W25798719592022 @default.
• W2579871959 crossrefType "journal-article" @default.
• W2579871959 hasAuthorship W2579871959A5025085488 @default.
• W2579871959 hasAuthorship W2579871959A5027951754 @default.
• W2579871959 hasAuthorship W2579871959A5033406574 @default.
• W2579871959 hasAuthorship W2579871959A5036981821 @default.
• W2579871959 hasAuthorship W2579871959A5041920873 @default.
• W2579871959 hasAuthorship W2579871959A5047692275 @default.
• W2579871959 hasAuthorship W2579871959A5047807604 @default.
• W2579871959 hasAuthorship W2579871959A5054757083 @default.
• W2579871959 hasAuthorship W2579871959A5065779609 @default.
• W2579871959 hasAuthorship W2579871959A5075860605 @default.
• W2579871959 hasAuthorship W2579871959A5090230000 @default.
• W2579871959 hasBestOaLocation W25798719591 @default.
• W2579871959 hasConcept C120665830 @default.
• W2579871959 hasConcept C121332964 @default.
• W2579871959 hasConcept C126322002 @default.
• W2579871959 hasConcept C17991360 @default.
• W2579871959 hasConcept C197934379 @default.
• W2579871959 hasConcept C198451711 @default.
• W2579871959 hasConcept C207103383 @default.
• W2579871959 hasConcept C2777138892 @default.
• W2579871959 hasConcept C2777178219 @default.
• W2579871959 hasConcept C2777226972 @default.
• W2579871959 hasConcept C2777575956 @default.
• W2579871959 hasConcept C2779722408 @default.
• W2579871959 hasConcept C2780132546 @default.
• W2579871959 hasConcept C44249647 @default.
• W2579871959 hasConcept C61511704 @default.
• W2579871959 hasConcept C71924100 @default.
• W2579871959 hasConcept C72563966 @default.
• W2579871959 hasConceptScore W2579871959C120665830 @default.
• W2579871959 hasConceptScore W2579871959C121332964 @default.
• W2579871959 hasConceptScore W2579871959C126322002 @default.
• W2579871959 hasConceptScore W2579871959C17991360 @default.
• W2579871959 hasConceptScore W2579871959C197934379 @default.
• W2579871959 hasConceptScore W2579871959C198451711 @default.
• W2579871959 hasConceptScore W2579871959C207103383 @default.
• W2579871959 hasConceptScore W2579871959C2777138892 @default.
• W2579871959 hasConceptScore W2579871959C2777178219 @default.
• W2579871959 hasConceptScore W2579871959C2777226972 @default.
• W2579871959 hasConceptScore W2579871959C2777575956 @default.
• W2579871959 hasConceptScore W2579871959C2779722408 @default.

• next