FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579943593> ?p ?o ?g. }

• W2579943593 abstract "Abstract c-Myb is a transcription factor that plays a key role in cell proliferation, differentiation, and apoptosis. It has been reported that c-Myb is expressed within the chicken otic placode, but whether c-Myb exists in the mammalian cochlea, and how it exerts its effects, has not been explored yet. Here, we investigated the expression of c-Myb in the postnatal mouse cochlea and HEI-OC1 cells and found that c-Myb was expressed in the hair cells (HCs) of mouse cochlea as well as in cultured HEI-OC1 cells. Next, we demonstrated that c-Myb expression was decreased in response to neomycin treatment in both cochlear HCs and HEI-OC1 cells, suggesting an otoprotective role for c-Myb. We then knocked down c-Myb expression with shRNA transfection in HEI-OC1 cells and found that c-Myb knockdown decreased cell viability, increased expression of pro-apoptotic factors, and enhanced cell apoptosis after neomycin insult. Mechanistic studies revealed that c-Myb knockdown increased cellular levels of reactive oxygen species and decreased Bcl-2 expression, both of which are likely to be responsible for the increased sensitivity of c-Myb knockdown cells to neomycin. This study provides evidence that c-Myb might serve as a new target for the prevention of aminoglycoside-induced HC loss." @default.
• W2579943593 created "2017-02-03" @default.
• W2579943593 creator A5007312763 @default.
• W2579943593 creator A5010150398 @default.
• W2579943593 creator A5011079131 @default.
• W2579943593 creator A5016795467 @default.
• W2579943593 creator A5039252463 @default.
• W2579943593 creator A5044381789 @default.
• W2579943593 creator A5045383704 @default.
• W2579943593 creator A5047187143 @default.
• W2579943593 creator A5049031669 @default.
• W2579943593 creator A5053689452 @default.
• W2579943593 creator A5065463742 @default.
• W2579943593 creator A5070623951 @default.
• W2579943593 creator A5086839633 @default.
• W2579943593 creator A5090949378 @default.
• W2579943593 date "2017-01-23" @default.
• W2579943593 modified "2023-10-04" @default.
• W2579943593 title "c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro" @default.
• W2579943593 cites W1506642042 @default.
• W2579943593 cites W1681122594 @default.
• W2579943593 cites W1967912613 @default.
• W2579943593 cites W1968612753 @default.
• W2579943593 cites W1978785103 @default.
• W2579943593 cites W1982421412 @default.
• W2579943593 cites W1982677778 @default.
• W2579943593 cites W1982718450 @default.
• W2579943593 cites W1985874110 @default.
• W2579943593 cites W1986862726 @default.
• W2579943593 cites W1987098181 @default.
• W2579943593 cites W1988402119 @default.
• W2579943593 cites W1988501412 @default.
• W2579943593 cites W1994993971 @default.
• W2579943593 cites W2007096781 @default.
• W2579943593 cites W2012480147 @default.
• W2579943593 cites W2016707802 @default.
• W2579943593 cites W2022569128 @default.
• W2579943593 cites W2023014537 @default.
• W2579943593 cites W2038333935 @default.
• W2579943593 cites W2046124242 @default.
• W2579943593 cites W2052038718 @default.
• W2579943593 cites W2052686187 @default.
• W2579943593 cites W2053124569 @default.
• W2579943593 cites W2053420373 @default.
• W2579943593 cites W2055833846 @default.
• W2579943593 cites W2058246794 @default.
• W2579943593 cites W2058489465 @default.
• W2579943593 cites W2064127449 @default.
• W2579943593 cites W2068716547 @default.
• W2579943593 cites W2076402417 @default.
• W2579943593 cites W2077987105 @default.
• W2579943593 cites W2082396725 @default.
• W2579943593 cites W2086551569 @default.
• W2579943593 cites W2094849559 @default.
• W2579943593 cites W2102427988 @default.
• W2579943593 cites W2113999599 @default.
• W2579943593 cites W2121966499 @default.
• W2579943593 cites W2139422271 @default.
• W2579943593 cites W2164898237 @default.
• W2579943593 cites W2170523250 @default.
• W2579943593 cites W2170803730 @default.
• W2579943593 cites W2284075572 @default.
• W2579943593 cites W2293889193 @default.
• W2579943593 cites W2331733158 @default.
• W2579943593 cites W2331943142 @default.
• W2579943593 cites W2397007275 @default.
• W2579943593 cites W2473915971 @default.
• W2579943593 cites W2512128868 @default.
• W2579943593 cites W2520094287 @default.
• W2579943593 cites W4210415242 @default.
• W2579943593 doi "https://doi.org/10.1038/srep41094" @default.
• W2579943593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5253735" @default.
• W2579943593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28112219" @default.
• W2579943593 hasPublicationYear "2017" @default.
• W2579943593 type Work @default.
• W2579943593 sameAs 2579943593 @default.
• W2579943593 citedByCount "48" @default.
• W2579943593 countsByYear W25799435932017 @default.
• W2579943593 countsByYear W25799435932018 @default.
• W2579943593 countsByYear W25799435932019 @default.
• W2579943593 countsByYear W25799435932020 @default.
• W2579943593 countsByYear W25799435932021 @default.
• W2579943593 countsByYear W25799435932022 @default.
• W2579943593 countsByYear W25799435932023 @default.
• W2579943593 crossrefType "journal-article" @default.
• W2579943593 hasAuthorship W2579943593A5007312763 @default.
• W2579943593 hasAuthorship W2579943593A5010150398 @default.
• W2579943593 hasAuthorship W2579943593A5011079131 @default.
• W2579943593 hasAuthorship W2579943593A5016795467 @default.
• W2579943593 hasAuthorship W2579943593A5039252463 @default.
• W2579943593 hasAuthorship W2579943593A5044381789 @default.
• W2579943593 hasAuthorship W2579943593A5045383704 @default.
• W2579943593 hasAuthorship W2579943593A5047187143 @default.
• W2579943593 hasAuthorship W2579943593A5049031669 @default.
• W2579943593 hasAuthorship W2579943593A5053689452 @default.
• W2579943593 hasAuthorship W2579943593A5065463742 @default.
• W2579943593 hasAuthorship W2579943593A5070623951 @default.
• W2579943593 hasAuthorship W2579943593A5086839633 @default.
• W2579943593 hasAuthorship W2579943593A5090949378 @default.
• W2579943593 hasBestOaLocation W25799435931 @default.

• next