Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579956670> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2579956670 abstract "Objective: Status dystonicus is a rare entity with few specific treatment options. We present two cases with histories of severe spasms, necessitating intrathecal baclofen pump placement, who both required intubation for status dystonicus. It was not until use of haloperidol as a preventative and abortive agent, that there was significantly decreased spasm frequency and severity in these patients. Cases: Patient 1 is a 40-year-old man with cerebral palsy and spasms controlled with a baclofen pump who was admitted for increasing spasms. Treatment with trihexyphenidyl, increasing amounts of baclofen (oral and intrathecal) and onabotulinumtoxinA injections lessened spasm frequency but did not eliminate them. High doses of diazepam and lorazepam (greater than 70 and 50mg respectively) also failed to control his spasms, so he was intubated and sedated with propofol. After continuing to have spasms on propofol, haloperidol 5mg IV was started for abortive therapy and this proved effective. Haloperidol 5mg PO TID was given standing as prophylaxis and he has done well since. Patient 2 is a 48-year-old man with neurofibromatosis type-1 who presented with increasing full-body spasms despite a functioning baclofen pump. He was uptitrated to a regimen of clonzapeam 1mg BID, dantrolene 25 daily, tizanidine 8mg TID, and lorazepam 10-15 mg IV as needed. These spells proved refractory and when their frequency continued to increase accompanied by brief periods of apnea, he was intubated and sedated with propofol. Haloperidol 5 mg TID was initiated as prophylaxis with better spasm control such that he was able to ambulate again. Discussion: Although haloperidol can be an inciting factor in dystonic reactions, there have been some reports in the literature regarding its use in status dystonicus. These cases illustrate the importance of considering alternative agents in treating status dystonicus, and the feasibility of using haloperidolas an abortive and preventative agent. Disclosure: Dr. George has nothing to disclose. Dr. Machado has nothing to disclose." @default.
- W2579956670 created "2017-02-03" @default.
- W2579956670 creator A5018082282 @default.
- W2579956670 creator A5027261499 @default.
- W2579956670 date "2016-04-05" @default.
- W2579956670 modified "2023-09-28" @default.
- W2579956670 title "Haloperidol as an Abortive and Preventative Agent in Status Dystonicus (P2.352)" @default.
- W2579956670 hasPublicationYear "2016" @default.
- W2579956670 type Work @default.
- W2579956670 sameAs 2579956670 @default.
- W2579956670 citedByCount "0" @default.
- W2579956670 crossrefType "journal-article" @default.
- W2579956670 hasAuthorship W2579956670A5018082282 @default.
- W2579956670 hasAuthorship W2579956670A5027261499 @default.
- W2579956670 hasConcept C126322002 @default.
- W2579956670 hasConcept C170493617 @default.
- W2579956670 hasConcept C2776175493 @default.
- W2579956670 hasConcept C2776277131 @default.
- W2579956670 hasConcept C2778938600 @default.
- W2579956670 hasConcept C2779706987 @default.
- W2579956670 hasConcept C2780948584 @default.
- W2579956670 hasConcept C2781201050 @default.
- W2579956670 hasConcept C42219234 @default.
- W2579956670 hasConcept C513476851 @default.
- W2579956670 hasConcept C71924100 @default.
- W2579956670 hasConceptScore W2579956670C126322002 @default.
- W2579956670 hasConceptScore W2579956670C170493617 @default.
- W2579956670 hasConceptScore W2579956670C2776175493 @default.
- W2579956670 hasConceptScore W2579956670C2776277131 @default.
- W2579956670 hasConceptScore W2579956670C2778938600 @default.
- W2579956670 hasConceptScore W2579956670C2779706987 @default.
- W2579956670 hasConceptScore W2579956670C2780948584 @default.
- W2579956670 hasConceptScore W2579956670C2781201050 @default.
- W2579956670 hasConceptScore W2579956670C42219234 @default.
- W2579956670 hasConceptScore W2579956670C513476851 @default.
- W2579956670 hasConceptScore W2579956670C71924100 @default.
- W2579956670 hasLocation W25799566701 @default.
- W2579956670 hasOpenAccess W2579956670 @default.
- W2579956670 hasPrimaryLocation W25799566701 @default.
- W2579956670 hasRelatedWork W1599637743 @default.
- W2579956670 hasRelatedWork W162784303 @default.
- W2579956670 hasRelatedWork W1966334931 @default.
- W2579956670 hasRelatedWork W2024663700 @default.
- W2579956670 hasRelatedWork W2029432672 @default.
- W2579956670 hasRelatedWork W2069108111 @default.
- W2579956670 hasRelatedWork W2088369589 @default.
- W2579956670 hasRelatedWork W2115063320 @default.
- W2579956670 hasRelatedWork W2254367057 @default.
- W2579956670 hasRelatedWork W2278564083 @default.
- W2579956670 hasRelatedWork W2397387931 @default.
- W2579956670 hasRelatedWork W2416613159 @default.
- W2579956670 hasRelatedWork W2513658375 @default.
- W2579956670 hasRelatedWork W2550291556 @default.
- W2579956670 hasRelatedWork W3000058348 @default.
- W2579956670 hasRelatedWork W3003268012 @default.
- W2579956670 hasRelatedWork W3176251142 @default.
- W2579956670 hasRelatedWork W3184837910 @default.
- W2579956670 hasRelatedWork W3209335810 @default.
- W2579956670 hasRelatedWork W2184407522 @default.
- W2579956670 hasVolume "86" @default.
- W2579956670 isParatext "false" @default.
- W2579956670 isRetracted "false" @default.
- W2579956670 magId "2579956670" @default.
- W2579956670 workType "article" @default.