Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579968156> ?p ?o ?g. }
- W2579968156 endingPage "415" @default.
- W2579968156 startingPage "415" @default.
- W2579968156 abstract "Many adverse health outcomes are associated with obstructive sleep apnea (OSA).To review primary care-relevant evidence on screening adults for OSA, test accuracy, and treatment of OSA, to inform the US Preventive Services Task Force.MEDLINE, Cochrane Library, EMBASE, and trial registries through October 2015, references, and experts, with surveillance of the literature through October 5, 2016.English-language randomized clinical trials (RCTs); studies evaluating accuracy of screening questionnaires or prediction tools, diagnostic accuracy of portable monitors, or association between apnea-hypopnea index (AHI) and health outcomes among community-based participants.Two investigators independently reviewed abstracts and full-text articles. When multiple similar studies were available, random-effects meta-analyses were conducted.Sensitivity, specificity, area under the curve (AUC), AHI, Epworth Sleepiness Scale (ESS) scores, blood pressure, mortality, cardiovascular events, motor vehicle crashes, quality of life, and harms.A total of 110 studies were included (N = 46 188). No RCTs compared screening with no screening. In 2 studies (n = 702), the screening accuracy of the multivariable apnea prediction score followed by home portable monitor testing for detecting severe OSA syndrome (AHI ≥30 and ESS score >10) was AUC 0.80 (95% CI, 0.78 to 0.82) and 0.83 (95% CI, 0.77 to 0.90), respectively, but the studies oversampled high-risk participants and those with OSA and OSA syndrome. No studies prospectively evaluated screening tools to report calibration or clinical utility for improving health outcomes. Meta-analysis found that continuous positive airway pressure (CPAP) compared with sham was significantly associated with reduction of AHI (weighted mean difference [WMD], -33.8 [95% CI, -42.0 to -25.6]; 13 trials, 543 participants), excessive sleepiness assessed by ESS score (WMD, -2.0 [95% CI, -2.6 to -1.4]; 22 trials, 2721 participants), diurnal systolic blood pressure (WMD, -2.4 points [95% CI, -3.9 to -0.9]; 15 trials, 1190 participants), and diurnal diastolic blood pressure (WMD, -1.3 points [95% CI, -2.2 to -0.4]; 15 trials, 1190 participants). CPAP was associated with modest improvement in sleep-related quality of life (Cohen d, 0.28 [95% CI, 0.14 to 0.42]; 13 trials, 2325 participants). Mandibular advancement devices (MADs) and weight loss programs were also associated with reduced AHI and excessive sleepiness. Common adverse effects of CPAP and MADs included oral or nasal dryness, irritation, and pain, among others. In cohort studies, there was a consistent association between AHI and all-cause mortality.There is uncertainty about the accuracy or clinical utility of all potential screening tools. Multiple treatments for OSA reduce AHI, ESS scores, and blood pressure. Trials of CPAP and other treatments have not established whether treatment reduces mortality or improves most other health outcomes, except for modest improvement in sleep-related quality of life." @default.
- W2579968156 created "2017-02-03" @default.
- W2579968156 creator A5020378692 @default.
- W2579968156 creator A5026068902 @default.
- W2579968156 creator A5036643072 @default.
- W2579968156 creator A5052083424 @default.
- W2579968156 creator A5060126779 @default.
- W2579968156 creator A5073935870 @default.
- W2579968156 creator A5076399844 @default.
- W2579968156 creator A5086245154 @default.
- W2579968156 date "2017-01-24" @default.
- W2579968156 modified "2023-10-13" @default.
- W2579968156 title "Screening for Obstructive Sleep Apnea in Adults" @default.
- W2579968156 cites W1492747692 @default.
- W2579968156 cites W1494184446 @default.
- W2579968156 cites W1498824860 @default.
- W2579968156 cites W1512041384 @default.
- W2579968156 cites W1522859516 @default.
- W2579968156 cites W1545241942 @default.
- W2579968156 cites W1567299047 @default.
- W2579968156 cites W1583834060 @default.
- W2579968156 cites W1638622873 @default.
- W2579968156 cites W167701172 @default.
- W2579968156 cites W1819447783 @default.
- W2579968156 cites W187665295 @default.
- W2579968156 cites W18880820 @default.
- W2579968156 cites W1906082462 @default.
- W2579968156 cites W1955906838 @default.
- W2579968156 cites W1963649284 @default.
- W2579968156 cites W1966157054 @default.
- W2579968156 cites W1966657660 @default.
- W2579968156 cites W1968162154 @default.
- W2579968156 cites W1968884608 @default.
- W2579968156 cites W1970149092 @default.
- W2579968156 cites W1972287997 @default.
- W2579968156 cites W1972401688 @default.
- W2579968156 cites W1973948212 @default.
- W2579968156 cites W1976286388 @default.
- W2579968156 cites W1977036795 @default.
- W2579968156 cites W1977228997 @default.
- W2579968156 cites W1980732575 @default.
- W2579968156 cites W1985408831 @default.
- W2579968156 cites W1988254324 @default.
- W2579968156 cites W1988537860 @default.
- W2579968156 cites W1989690119 @default.
- W2579968156 cites W1992520316 @default.
- W2579968156 cites W1993455338 @default.
- W2579968156 cites W1994379541 @default.
- W2579968156 cites W1994381724 @default.
- W2579968156 cites W1995835613 @default.
- W2579968156 cites W2005403698 @default.
- W2579968156 cites W2007920108 @default.
- W2579968156 cites W2008027535 @default.
- W2579968156 cites W2011094396 @default.
- W2579968156 cites W2015103786 @default.
- W2579968156 cites W2016399889 @default.
- W2579968156 cites W2017634623 @default.
- W2579968156 cites W2022358071 @default.
- W2579968156 cites W2027450779 @default.
- W2579968156 cites W2030161662 @default.
- W2579968156 cites W2031552314 @default.
- W2579968156 cites W2034556696 @default.
- W2579968156 cites W2037816964 @default.
- W2579968156 cites W2042958005 @default.
- W2579968156 cites W2043318845 @default.
- W2579968156 cites W2044617730 @default.
- W2579968156 cites W2046029379 @default.
- W2579968156 cites W2046298535 @default.
- W2579968156 cites W2046650787 @default.
- W2579968156 cites W2047132452 @default.
- W2579968156 cites W2048437465 @default.
- W2579968156 cites W2049340111 @default.
- W2579968156 cites W2051512233 @default.
- W2579968156 cites W2053090072 @default.
- W2579968156 cites W2053447916 @default.
- W2579968156 cites W2056241050 @default.
- W2579968156 cites W2057252459 @default.
- W2579968156 cites W2062177488 @default.
- W2579968156 cites W2065694980 @default.
- W2579968156 cites W2065948880 @default.
- W2579968156 cites W2068017066 @default.
- W2579968156 cites W2069163578 @default.
- W2579968156 cites W2073960829 @default.
- W2579968156 cites W2074965921 @default.
- W2579968156 cites W2075726900 @default.
- W2579968156 cites W2076066018 @default.
- W2579968156 cites W2076947946 @default.
- W2579968156 cites W2078835677 @default.
- W2579968156 cites W2079485496 @default.
- W2579968156 cites W2081226646 @default.
- W2579968156 cites W2084009434 @default.
- W2579968156 cites W2086889066 @default.
- W2579968156 cites W2087999452 @default.
- W2579968156 cites W2089941212 @default.
- W2579968156 cites W2090280604 @default.
- W2579968156 cites W2090732173 @default.
- W2579968156 cites W2092853881 @default.
- W2579968156 cites W2098255212 @default.