FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579968803> ?p ?o ?g. }

• W2579968803 endingPage "154" @default.
• W2579968803 startingPage "147" @default.
• W2579968803 abstract "Abundant clinical data now confirm that ketamine produces a remarkable rapid-onset antidepressant effect - hours or days - in contrast to the delayed onset (typically weeks) of current antidepressant drugs. This surprising and revolutionary finding may lead to the development of life-saving pharmacotherapy for depressive illness by reducing the high suicide risk associated with the delayed onset of effect of current drugs. As ketamine has serious self-limiting drawbacks that restrict its widespread use for this purpose, a safer alternative is needed. Our objective is to review the proposed mechanism(s) of ketamine's rapid-onset antidepressant action for new insights into the physiological basis of depressive illness that may lead to new and novel targets for antidepressant drug discovery.A search was conducted on published literature (e.g. PubMed) and Internet sources to identify information relevant to ketamine's rapid-acting antidepressant action and, specifically, to the possible mechanism(s) of this action. Key search words included 'ketamine', 'antidepressant', 'mechanism of action', 'depression' and 'rapid acting', either individually or in combination. Information was sought that would include less well-known, as well as well-known, basic pharmacologic properties of ketamine and that identified and evaluated the several hypotheses about ketamine's mechanism of antidepressant action.Whether the mechanistic explanation for ketamine's rapid-onset antidepressant action is related to its well-known antagonism of the NMDA (N-Methyl-d-aspartate) subtype of glutamate receptor or to something else has not yet been fully elucidated. The evidence from pharmacologic, medicinal chemistry, animal model and drug-discovery sources reveals a wide variety of postulated mechanisms.The surprising discovery of ketamine's rapid-onset antidepressant effect is a game-changer for the understanding and treatment of depressive illness. There is some convergence on NMDA receptor antagonism as a likely, but to date unproven, common mechanism. The surprising number of other mechanisms, and the several novel biochemical aetiologies of depression proposed, suggests exciting new drug-discovery targets." @default.
• W2579968803 created "2017-02-03" @default.
• W2579968803 creator A5001525918 @default.
• W2579968803 creator A5022493415 @default.
• W2579968803 creator A5035360505 @default.
• W2579968803 creator A5037722078 @default.
• W2579968803 creator A5038689814 @default.
• W2579968803 creator A5038953801 @default.
• W2579968803 creator A5048782518 @default.
• W2579968803 creator A5052650393 @default.
• W2579968803 creator A5056645661 @default.
• W2579968803 creator A5056693005 @default.
• W2579968803 creator A5057223319 @default.
• W2579968803 creator A5071793001 @default.
• W2579968803 creator A5077593052 @default.
• W2579968803 date "2017-01-22" @default.
• W2579968803 modified "2023-09-27" @default.
• W2579968803 title "What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities" @default.
• W2579968803 cites W1151348585 @default.
• W2579968803 cites W1561342581 @default.
• W2579968803 cites W1568032404 @default.
• W2579968803 cites W184284683 @default.
• W2579968803 cites W1964466640 @default.
• W2579968803 cites W1964709968 @default.
• W2579968803 cites W1969919708 @default.
• W2579968803 cites W1970328639 @default.
• W2579968803 cites W1977073959 @default.
• W2579968803 cites W1982312356 @default.
• W2579968803 cites W1984167101 @default.
• W2579968803 cites W1988619982 @default.
• W2579968803 cites W1995094023 @default.
• W2579968803 cites W1996081929 @default.
• W2579968803 cites W2002553836 @default.
• W2579968803 cites W2005593490 @default.
• W2579968803 cites W2006611387 @default.
• W2579968803 cites W2006861654 @default.
• W2579968803 cites W2011339930 @default.
• W2579968803 cites W2013406264 @default.
• W2579968803 cites W2018922460 @default.
• W2579968803 cites W2022499907 @default.
• W2579968803 cites W2022994360 @default.
• W2579968803 cites W2038066039 @default.
• W2579968803 cites W2039961483 @default.
• W2579968803 cites W2040144681 @default.
• W2579968803 cites W2043116438 @default.
• W2579968803 cites W2045639714 @default.
• W2579968803 cites W2046489639 @default.
• W2579968803 cites W2046955370 @default.
• W2579968803 cites W2047397795 @default.
• W2579968803 cites W2052830386 @default.
• W2579968803 cites W2053823989 @default.
• W2579968803 cites W2060150052 @default.
• W2579968803 cites W2061935788 @default.
• W2579968803 cites W2063056261 @default.
• W2579968803 cites W2075655412 @default.
• W2579968803 cites W2078029525 @default.
• W2579968803 cites W2079274909 @default.
• W2579968803 cites W2086726646 @default.
• W2579968803 cites W2089198034 @default.
• W2579968803 cites W2089351762 @default.
• W2579968803 cites W2094384948 @default.
• W2579968803 cites W2095390653 @default.
• W2579968803 cites W2108057532 @default.
• W2579968803 cites W2108212317 @default.
• W2579968803 cites W2111247524 @default.
• W2579968803 cites W2121117021 @default.
• W2579968803 cites W2122215517 @default.
• W2579968803 cites W2123670954 @default.
• W2579968803 cites W2124203952 @default.
• W2579968803 cites W2128264965 @default.
• W2579968803 cites W2133029204 @default.
• W2579968803 cites W2137491012 @default.
• W2579968803 cites W2137992068 @default.
• W2579968803 cites W2142002093 @default.
• W2579968803 cites W2146758523 @default.
• W2579968803 cites W2157040702 @default.
• W2579968803 cites W2158031806 @default.
• W2579968803 cites W2160011621 @default.
• W2579968803 cites W2162610070 @default.
• W2579968803 cites W2168927779 @default.
• W2579968803 cites W2170219130 @default.
• W2579968803 cites W2170790660 @default.
• W2579968803 cites W2171672882 @default.
• W2579968803 cites W2332800117 @default.
• W2579968803 cites W4247665917 @default.
• W2579968803 doi "https://doi.org/10.1111/jcpt.12497" @default.
• W2579968803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28111761" @default.
• W2579968803 hasPublicationYear "2017" @default.
• W2579968803 type Work @default.
• W2579968803 sameAs 2579968803 @default.
• W2579968803 citedByCount "61" @default.
• W2579968803 countsByYear W25799688032017 @default.
• W2579968803 countsByYear W25799688032018 @default.
• W2579968803 countsByYear W25799688032019 @default.
• W2579968803 countsByYear W25799688032020 @default.
• W2579968803 countsByYear W25799688032021 @default.
• W2579968803 countsByYear W25799688032022 @default.
• W2579968803 countsByYear W25799688032023 @default.

• next