FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2579969776> ?p ?o ?g. }

• W2579969776 endingPage "530" @default.
• W2579969776 startingPage "521" @default.
• W2579969776 abstract "Purpose: Depression is a public disorder worldwide. Despite the widespread use of venlafaxine in the treatment of depression, it has been associated with the incidence of toxicities. Hence, the goal of the current investigation was to evaluate the mechanisms of venlafaxine-induced cell death in the model of the freshly isolated rat hepatocytes. Methods: Collagenase-perfused rat hepatocytes were treated with venlafaxine and other agents. Cell damage, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial membrane potential decline, lysosomal damage, glutathione (GSH) level were analyzed. Moreover, rat liver mitochondria were isolated through differential centrifugation to assess respiratory chain functionality. Results: Our results demonstrated that venlafaxine could induce ROS formation followed by lipid peroxidation, cellular GSH content depletion, elevated GSSG level, loss of lysosmal membrane integrity, MMP collapse and finally cell death in a concentration-dependent manner. N-acetyl cysteine, taurine and quercetine significantly decreased the aforementioned venlafaxine-induced cellular events. Also, radical scavenger (butylatedhydroxytoluene and α-tocopherol), CYP2E1 inhibitor (4-methylpyrazole), lysosomotropic agents (methylamine and chloroquine), ATP generators (L-gluthamine and fructose) and mitochondrial pore sealing agents (trifluoperazine and L-carnitine) considerably reduced cytotoxicity, ROS generation and lysosomal leakage following venlafaxine treatment. Mitochondrion dysfunction was concomitant with the blockade of the electron transfer complexes II and IV of the mitochondrial respiratory system. Conclusion: Therefore, our data indicate that venlafaxine induces oxidative stress towards hepatocytes and our findings provide evidence to propose that mitochondria and lysosomes are of the primary targets in venlafaxine-mediated cell damage." @default.
• W2579969776 created "2017-02-03" @default.
• W2579969776 creator A5041821699 @default.
• W2579969776 creator A5054041119 @default.
• W2579969776 creator A5062413567 @default.
• W2579969776 creator A5068985799 @default.
• W2579969776 creator A5085023507 @default.
• W2579969776 date "2016-12-22" @default.
• W2579969776 modified "2023-10-18" @default.
• W2579969776 title "Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction" @default.
• W2579969776 cites W1556790004 @default.
• W2579969776 cites W1597011288 @default.
• W2579969776 cites W169424280 @default.
• W2579969776 cites W1896019570 @default.
• W2579969776 cites W1902796268 @default.
• W2579969776 cites W1941109772 @default.
• W2579969776 cites W1972147779 @default.
• W2579969776 cites W1980168340 @default.
• W2579969776 cites W1985469636 @default.
• W2579969776 cites W1992782534 @default.
• W2579969776 cites W2002283108 @default.
• W2579969776 cites W2002805664 @default.
• W2579969776 cites W2006189794 @default.
• W2579969776 cites W2012533693 @default.
• W2579969776 cites W2017593971 @default.
• W2579969776 cites W2018940119 @default.
• W2579969776 cites W2026943977 @default.
• W2579969776 cites W2028821805 @default.
• W2579969776 cites W2033630167 @default.
• W2579969776 cites W2045253296 @default.
• W2579969776 cites W2050415328 @default.
• W2579969776 cites W2056176211 @default.
• W2579969776 cites W2062465486 @default.
• W2579969776 cites W2062834612 @default.
• W2579969776 cites W2074545478 @default.
• W2579969776 cites W2074695669 @default.
• W2579969776 cites W2076823307 @default.
• W2579969776 cites W2076894270 @default.
• W2579969776 cites W2076913339 @default.
• W2579969776 cites W2080878773 @default.
• W2579969776 cites W2081947637 @default.
• W2579969776 cites W2088569046 @default.
• W2579969776 cites W2093374310 @default.
• W2579969776 cites W2102785500 @default.
• W2579969776 cites W2113085315 @default.
• W2579969776 cites W2117859857 @default.
• W2579969776 cites W2118564374 @default.
• W2579969776 cites W2129699864 @default.
• W2579969776 cites W2147136466 @default.
• W2579969776 cites W2151323454 @default.
• W2579969776 cites W2152749732 @default.
• W2579969776 cites W2154516093 @default.
• W2579969776 cites W2156610320 @default.
• W2579969776 cites W2156641852 @default.
• W2579969776 cites W2164687601 @default.
• W2579969776 cites W2166337262 @default.
• W2579969776 cites W2341288238 @default.
• W2579969776 cites W2411945685 @default.
• W2579969776 cites W2467234808 @default.
• W2579969776 cites W2468992171 @default.
• W2579969776 cites W2470337695 @default.
• W2579969776 cites W2493532317 @default.
• W2579969776 cites W64700927 @default.
• W2579969776 doi "https://doi.org/10.15171/apb.2016.066" @default.
• W2579969776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5241410" @default.
• W2579969776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28101459" @default.
• W2579969776 hasPublicationYear "2016" @default.
• W2579969776 type Work @default.
• W2579969776 sameAs 2579969776 @default.
• W2579969776 citedByCount "48" @default.
• W2579969776 countsByYear W25799697762017 @default.
• W2579969776 countsByYear W25799697762018 @default.
• W2579969776 countsByYear W25799697762019 @default.
• W2579969776 countsByYear W25799697762020 @default.
• W2579969776 countsByYear W25799697762021 @default.
• W2579969776 countsByYear W25799697762022 @default.
• W2579969776 countsByYear W25799697762023 @default.
• W2579969776 crossrefType "journal-article" @default.
• W2579969776 hasAuthorship W2579969776A5041821699 @default.
• W2579969776 hasAuthorship W2579969776A5054041119 @default.
• W2579969776 hasAuthorship W2579969776A5062413567 @default.
• W2579969776 hasAuthorship W2579969776A5068985799 @default.
• W2579969776 hasAuthorship W2579969776A5085023507 @default.
• W2579969776 hasBestOaLocation W25799697761 @default.
• W2579969776 hasConcept C134018914 @default.
• W2579969776 hasConcept C13591479 @default.
• W2579969776 hasConcept C181199279 @default.
• W2579969776 hasConcept C185592680 @default.
• W2579969776 hasConcept C190283241 @default.
• W2579969776 hasConcept C2776151105 @default.
• W2579969776 hasConcept C2776466888 @default.
• W2579969776 hasConcept C2779177272 @default.
• W2579969776 hasConcept C2780829032 @default.
• W2579969776 hasConcept C2781161787 @default.
• W2579969776 hasConcept C28859421 @default.
• W2579969776 hasConcept C31573885 @default.
• W2579969776 hasConcept C48349386 @default.
• W2579969776 hasConcept C538909803 @default.

• next