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- W2580023605 abstract "Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of 'priming' was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells." @default.
- W2580023605 created "2017-02-03" @default.
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- W2580023605 date "2017-01-27" @default.
- W2580023605 modified "2023-10-13" @default.
- W2580023605 title "Withania somnifera Root Extract Enhances Chemotherapy through ‘Priming’" @default.
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- W2580023605 doi "https://doi.org/10.1371/journal.pone.0170917" @default.
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