FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2580069701> ?p ?o ?g. }

• W2580069701 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs), transdermal fentanyl patches, and transmucosal buprenorphine are probably the most commonly used options for providing post-operative analgesia in the early at-home period. However, these require daily administration or are associated with abuse concerns. One of the significant unmet needs in veterinary surgery and pain management is for longer acting opioids for cats to effectively bridge the gap between the in-hospital and at-home recovery periods. A proof of concept study of an extended release formulation of buprenorphine HCL (ER-Bup) was conducted using objective kinetic measures and a unilateral onychectomy model. Using a blinded, randomized, two period crossover design, four cats were allocated to control (saline) or ER-Bup (0.6 mg/kg, subcutaneously [SC]) treatment groups. All animals underwent a unilateral forelimb onychectomy per period with a washout/recovery period in between. Observational pain scores and kinetic data (using a pressure sensitive walkway [PSW]) were collected prior to (baseline) and at intervals for 72 h following surgery. Symmetry indices were derived for kinetic variables (peak vertical force [PVF]; vertical impulse [VI]) of each forelimb for landing following a jump and for walking. A rescue analgesic protocol was in place. Effect of surgery and treatment were evaluated using a mixed model statistical approach. No cats required rescue analgesics based on subjective pain score. ER-Bup had a positive influence on subjective pain scores during the 72 h postsurgery (p = 0.0473). PVF and VI of the operated limb were significantly decreased for both landing (p < 0.0001 and p < 0.0001) and walking (p < 0.0001 and p < 0.0001 respectively) compared to control. ER-Bup resulted in significantly decreased asymmetry in limb use during landing (PVF, p < 0.0001; VI, p < 0.0001) and walking (PVF, p = 0.0002, VI, p < 0.0001). The novel use of data collected following a jump from an elevated platform appeared to provide all desired information and was easier to collect than walking data. This study demonstrates that SC administration of ER-Bup may be an effective analgesic for a 72 h period postoperatively. Furthermore, landing onto a PSW from an elevated perch may be a useful and efficient way to assess analgesics in cats using a unilateral model of limb pain." @default.
• W2580069701 created "2017-02-03" @default.
• W2580069701 creator A5001231316 @default.
• W2580069701 creator A5006941646 @default.
• W2580069701 creator A5051632063 @default.
• W2580069701 creator A5062007787 @default.
• W2580069701 creator A5068933060 @default.
• W2580069701 creator A5080857009 @default.
• W2580069701 creator A5090761651 @default.
• W2580069701 date "2016-12-01" @default.
• W2580069701 modified "2023-09-27" @default.
• W2580069701 title "Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product" @default.
• W2580069701 cites W1520980974 @default.
• W2580069701 cites W1989705750 @default.
• W2580069701 cites W1999380555 @default.
• W2580069701 cites W2008021560 @default.
• W2580069701 cites W2009903228 @default.
• W2580069701 cites W2014796883 @default.
• W2580069701 cites W2038872905 @default.
• W2580069701 cites W2053946674 @default.
• W2580069701 cites W2061390775 @default.
• W2580069701 cites W2068025142 @default.
• W2580069701 cites W2074393831 @default.
• W2580069701 cites W2074703272 @default.
• W2580069701 cites W2080212141 @default.
• W2580069701 cites W2080822676 @default.
• W2580069701 cites W2082415726 @default.
• W2580069701 cites W2089329176 @default.
• W2580069701 cites W2110019575 @default.
• W2580069701 cites W2114300719 @default.
• W2580069701 cites W2114957747 @default.
• W2580069701 cites W2119913334 @default.
• W2580069701 cites W2121203578 @default.
• W2580069701 cites W2122466517 @default.
• W2580069701 cites W2150900263 @default.
• W2580069701 cites W2152170746 @default.
• W2580069701 cites W2155937123 @default.
• W2580069701 cites W2169799142 @default.
• W2580069701 cites W2171433760 @default.
• W2580069701 cites W2417725649 @default.
• W2580069701 cites W58755620 @default.
• W2580069701 cites W9160839 @default.
• W2580069701 doi "https://doi.org/10.1186/s12917-017-0943-5" @default.
• W2580069701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5259973" @default.
• W2580069701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28118835" @default.
• W2580069701 hasPublicationYear "2016" @default.
• W2580069701 type Work @default.
• W2580069701 sameAs 2580069701 @default.
• W2580069701 citedByCount "5" @default.
• W2580069701 countsByYear W25800697012018 @default.
• W2580069701 countsByYear W25800697012019 @default.
• W2580069701 countsByYear W25800697012022 @default.
• W2580069701 crossrefType "journal-article" @default.
• W2580069701 hasAuthorship W2580069701A5001231316 @default.
• W2580069701 hasAuthorship W2580069701A5006941646 @default.
• W2580069701 hasAuthorship W2580069701A5051632063 @default.
• W2580069701 hasAuthorship W2580069701A5062007787 @default.
• W2580069701 hasAuthorship W2580069701A5068933060 @default.
• W2580069701 hasAuthorship W2580069701A5080857009 @default.
• W2580069701 hasAuthorship W2580069701A5090761651 @default.
• W2580069701 hasBestOaLocation W25800697011 @default.
• W2580069701 hasConcept C102959455 @default.
• W2580069701 hasConcept C105702510 @default.
• W2580069701 hasConcept C105795698 @default.
• W2580069701 hasConcept C126322002 @default.
• W2580069701 hasConcept C141071460 @default.
• W2580069701 hasConcept C142724271 @default.
• W2580069701 hasConcept C168563851 @default.
• W2580069701 hasConcept C170493617 @default.
• W2580069701 hasConcept C204787440 @default.
• W2580069701 hasConcept C205679159 @default.
• W2580069701 hasConcept C23131810 @default.
• W2580069701 hasConcept C27081682 @default.
• W2580069701 hasConcept C2775842315 @default.
• W2580069701 hasConcept C2777397205 @default.
• W2580069701 hasConcept C2778646069 @default.
• W2580069701 hasConcept C2778949969 @default.
• W2580069701 hasConcept C2780820201 @default.
• W2580069701 hasConcept C2781020239 @default.
• W2580069701 hasConcept C2781063702 @default.
• W2580069701 hasConcept C2781072394 @default.
• W2580069701 hasConcept C33923547 @default.
• W2580069701 hasConcept C42219234 @default.
• W2580069701 hasConcept C71924100 @default.
• W2580069701 hasConcept C87813604 @default.
• W2580069701 hasConcept C98274493 @default.
• W2580069701 hasConceptScore W2580069701C102959455 @default.
• W2580069701 hasConceptScore W2580069701C105702510 @default.
• W2580069701 hasConceptScore W2580069701C105795698 @default.
• W2580069701 hasConceptScore W2580069701C126322002 @default.
• W2580069701 hasConceptScore W2580069701C141071460 @default.
• W2580069701 hasConceptScore W2580069701C142724271 @default.
• W2580069701 hasConceptScore W2580069701C168563851 @default.
• W2580069701 hasConceptScore W2580069701C170493617 @default.
• W2580069701 hasConceptScore W2580069701C204787440 @default.
• W2580069701 hasConceptScore W2580069701C205679159 @default.
• W2580069701 hasConceptScore W2580069701C23131810 @default.
• W2580069701 hasConceptScore W2580069701C27081682 @default.
• W2580069701 hasConceptScore W2580069701C2775842315 @default.
• W2580069701 hasConceptScore W2580069701C2777397205 @default.

• next