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- W2580292466 endingPage "587" @default.
- W2580292466 startingPage "572" @default.
- W2580292466 abstract "Alzheimer’s disease (AD) is a neurodegenerative disorder, which is complex and progressive; it has not only threatened the health of elderly people, but also burdened the whole social medical and health system. The available therapy for AD is limited and the efficacy remains unsatisfactory. In view of the prevalence and expected increase in the incidence of AD, the design and development of efficacious and safe anti-AD agents has become a hotspot in the field of pharmaceutical research. Due to the multifactorial etiology of AD, the multitarget-directed ligands (MTDLs) approach is promising in search for new drugs for AD. Tacrine, which is the first acetylcholinesterase (AChE) inhibitor, has been selected as the ideal active fragment because of its simple structure, clear activity, and its superiority in the structural modification, thus it could be introduced into the overall molecular skeletons of the multi-target-directed anti-AD agents. In this review, we have summarized the recent advances (2012 to the present) in the chemical modification of tacrine, which could provide the reference for the further study of novel multi-target-directed tacrine derivatives to treat AD." @default.
- W2580292466 created "2017-02-03" @default.
- W2580292466 creator A5017600866 @default.
- W2580292466 creator A5055999528 @default.
- W2580292466 creator A5064313538 @default.
- W2580292466 creator A5069785047 @default.
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- W2580292466 creator A5077161148 @default.
- W2580292466 creator A5080420495 @default.
- W2580292466 creator A5086207660 @default.
- W2580292466 creator A5091905008 @default.
- W2580292466 date "2017-01-01" @default.
- W2580292466 modified "2023-10-18" @default.
- W2580292466 title "Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease" @default.
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